Results 151 to 160 of about 57,089 (325)
Frontiers in Pain ResearchIntroductionBiological aging and sex interact to shape systemic metabolism, yet their role in chronic pain resolution remains unexplored. We hypothesized that metabolic resilience—the ability to flexibly switch fuel sources and maintain energy ...
Sara Marinelli +15 more
doaj +1 more source
Pacific Blue Derivatives of Paclitaxel as Fluorescent Probes of OATP1B‐Type Transporters
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Paclitaxel (Taxol) is a widely used anticancer agent that undergoes extensive hepatic metabolism and that causes a debilitating, dose‐limiting peripheral neurotoxicity. We previously reported that the uptake of paclitaxel in hepatocytes and dorsal root ganglion neurons, the site of injury within the nervous system, is mediated by the organic ...
Mahesh R. Nepal +11 more
wiley +1 more source
Capsaican-evoked Mechanical Allodynia and Hyperalgesia Cross-nerve Territories [PDF]
, 1997 Leroy D. Vandam
openalex +1 more source
Advanced Therapeutics, Volume 9, Issue 1, January 2026.This study investigates the analgesic potential of extracellular vesicles derived from bone marrow mesenchymal stem cells (EV‐BMSC) in diabetic sensory neuropathy. EV‐BMSC reproduce the pain‐relieving effects of BMSC transplantation through opioid‐mediated mechanisms, highlighting a promising cell‐free therapeutic approach for neuropathic pain ...
Gessica S. A. Silva +8 more
wiley +1 more source
Characterization of nociceptin-induced allodynia and hyperalgesia
, 1998 Toshiaki Minami +5 more
openalex +1 more source
Metabotropic glutamate receptor
, 2023 Yike Li +9 more
openalex +1 more source
Advanced Science, Volume 13, Issue 2, 9 January 2026.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
STING mediates experimental osteoarthritis and mechanical allodynia in mouse [PDF]
, 2023 Youngnim Shin +3 more
openalex +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park +19 more
wiley +1 more source