Results 31 to 40 of about 57,089 (325)

Peedanil Gold, Herbo-Mineral Formulation, Moderates Cytokine Levels and Attenuates Pathophysiology in Monosodium Iodoacetate Induced Osteoarthritis in SD Rat Model

Frontiers in Pharmacology, 2022
The inflammatory cartilaginous degeneration of the articular joints, mostly those of knee, hips and hands, is osteoarthritis (OA). The available treatment strategies for osteoarthritis are designed for pain relief, molecular targeting, cartilage ...
Acharya Balkrishna, Acharya Balkrishna, Sandeep Sinha, Shadrak Karumuri, Jyotish Srivastava, Swati Haldar, Anurag Varshney, Anurag Varshney, Anurag Varshney   +8 more
doaj   +1 more source

Pain perception and migraine [PDF]

, 2018
Background: It is well-known that both inter-and intra-individual differences exist in the perception of pain; this is especially true in migraine, an elusive pain disorder of the head.
Coppola, Gianluca, Parisi, Vincenzo, Pierelli, Francesco, Russo, Antonio, Silvestro, Marcello, Tedeschi, Gioacchino, Tessitore, Alessandro   +6 more
core   +1 more source

Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral Pain

Frontiers in Physiology, 2017
Abnormal Ca2+ channel physiology, expression levels, and hypersensitivity to heat have been implicated in several pain states following treatment with chemotherapeutic agents.
Mustafa Nazıroğlu, Nady Braidy
doaj   +1 more source

Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models

Frontiers in Pain Research, 2023
Chronic post-surgical pain affects up to 85% of individuals depending on the type of surgery, the extent of inflammation, tissue and/or nerve damage. Pre-surgical stress is associated with greater pain intensity, prolonged recovery and is one of the main
Ariadni Bella, Ariadni Bella, Ariadni Bella, Alba M. Diego, Alba M. Diego, Alba M. Diego, David P. Finn, David P. Finn, David P. Finn, Michelle Roche, Michelle Roche, Michelle Roche   +11 more
doaj   +1 more source

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]

, 2019
© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta, Czoty, Paul W., DeLoid, Heather B., Ding, Huiping, Hsu, Fang Chi, Husbands, Stephen M., Kiguchi, Norikazu, Ko, Mei Chuan, Sukhtankar, Devki D., Toll, Lawrence   +9 more
core   +5 more sources

The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain

Frontiers in Pharmacology, 2023
Paclitaxel (sold under the brand name Taxol) is a chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Keun-Tae Park, Suyong Kim, Ilseob Choi, Ik-Hwan Han, Hyunsu Bae, Woojin Kim, Woojin Kim   +6 more
doaj   +1 more source

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier, Baron, Basbaum, Cai, Calignano, Callaghan, Caterina, Chen, Chen, Coderre, Costigan, Costigan, D. J. Anderson, De Felipe, Delmas, Dong, Gerevich, Guan, Guan, Herrero, Honan, Ikeda, Julius, Knabl, Kusudo, Lembo, Li, Li, Liu, Liu, Lu, MacDermott, MacPherson, Malmberg, Melzack, Melzack, Miraucourt, Ndong, Neumann, Q. Liu, Rau, Rodriguez Parkitna, S. N. Raja, Scholz, Seal, Woolf, X. Dong, Y. Guan, Z. Tang, Zeng   +49 more
core   +2 more sources

Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice

Antioxidants, 2022
Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H2) as a new therapy for neurological disorders has been demonstrated.
Santiago Coral-Pérez, Ignacio Martínez-Martel, Maria Martínez-Serrat, Gerard Batallé, Xue Bai, Christie R. A. Leite-Panissi, Olga Pol   +6 more
doaj   +1 more source

Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice [PDF]

, 2014
Objective. Osteoarthritis (OA) is a common chronic disease for which disease-modifying therapies are not currently available. Studies to seek new targets for slowing the progress of OA rely on mouse models, but these do not allow for longitudinal ...
Poulet, B, De Souza, R, Knights, C B, Gentry, C, Wilson, A M, Bevan, S, Chang, Y M, Pitsillides, A A, Fed Mato Grosso, King's, UCL   +10 more
core   +5 more sources

Pathophysiology and Therapy of Associated Features of Migraine

Cells, 2022
Migraine is a complex and debilitating disorder that is broadly recognised by its characteristic headache. However, given the wide array of clinical presentations in migraineurs, the headache might not represent the main troublesome symptom and it can ...
Maria Dolores Villar-Martinez, Peter J. Goadsby   +1 more
doaj   +1 more source