Results 71 to 80 of about 30,446 (212)

OnabotulinumtoxinA treatment among diverse racial groups: Post hoc analysis of the phase 4 Chronic migraine OnabotulinuMtoxinA Prolonged Efficacy open‐Label (COMPEL) trial

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective Examine treatment responses to and safety of onabotulinumtoxinA for the preventive treatment of chronic migraine (CM) among diverse racial groups. Background Evidence suggests there are differences in headache treatment patterns, symptom profiles, and burden based on race.
Andrew M. Blumenfeld, Larry Charleston IV, Deena Kuruvilla, Belinda Savage‐Edwards, Richard B. Lipton, Ritu Singh, Patricia Jacob, Nicole A. Lawrence, Cuiwei Wang, Hope L. O'Brien   +9 more
wiley   +1 more source

Integrating gepants into clinical practice for the acute treatment of migraine

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To assess the role of small‐molecule calcitonin gene–related peptide receptor antagonists (gepants) in the acute treatment of migraine, particularly in relation to triptan treatments. Background Triptans have established efficacy and are widely prescribed for the acute treatment of migraine.
Richard B. Lipton, David W. Dodick, Linda Davis, Stephanie J. Nahas, Peter J. Goadsby   +4 more
wiley   +1 more source

Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats

Molecules, 2015
Harpagophytum procumbens (H. procumbens), also known as Devil’s Claw, has been used to treat a wide range of pathological conditions, including pain, arthritis and inflammation.
Carmela Parenti, Giuseppina Aricò, Santina Chiechio, Giulia Di Benedetto, Rosalba Parenti, Giovanna M. Scoto   +5 more
doaj   +1 more source

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley   +1 more source

Postherpetic Neuralgia: Irritable Nociceptors and Deafferentation

Neurobiology of Disease, 1998
Postherpetic neuralgia (PHN) is a common and often devastatingly painful condition. It is also one of the most extensively investigated of the neuropathic pains. Patients with PHN have been studied using quantitative testing of primary afferent function,
Howard L. Fields, Michael Rowbotham, Ralf Baron   +2 more
doaj   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone

Frontiers in Cellular Neuroscience, 2014
A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor ...
Pierrick ePoisbeau, Florence eKeller, Florence eKeller, Maya eAouad, Nisrine eKamoun, Ghislaine eGroyer, Michael eSchumacher   +6 more
doaj   +1 more source

Evaluating associations of migraine-related vertigo. [PDF]

Headache
Abstract Objective We set out to examine detailed phenotypic data from our clinic for associations of vertigo in chronic migraine. Background Vertigo is a non‐canonical, common symptom of migraine. Little is known about its associations with other symptoms within the migraine phenotype.
Karsan N, Vandenbussche N, Jenia-Wilcha R, Amarasena P, Soontrapa P, Nagaraj K, Perez CL, Goadsby PJ.   +7 more
europepmc   +2 more sources

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source