Results 71 to 80 of about 172 (108)
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The Journal of Immunology, 2022
Abstract Pancreatic cancer is one of the most malignant solid tumors with a high mortality rate. Although there have been many trials for effective therapies using chemotherapeutic drugs, such as gemcitabine, pancreatic cancer still shows significantly higher mortality than other types of cancer.
HyeJung Jo +4 more
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Abstract Pancreatic cancer is one of the most malignant solid tumors with a high mortality rate. Although there have been many trials for effective therapies using chemotherapeutic drugs, such as gemcitabine, pancreatic cancer still shows significantly higher mortality than other types of cancer.
HyeJung Jo +4 more
openaire +1 more source
Activation of NF-κB by alloferon through down-regulation of antioxidant proteins and IκBα
Molecular and Cellular Biochemistry, 2008Alloferon is a 13-amino acid peptide isolated from the bacteria-challenged larvae of the blow fly Calliphora vicina. The pharmaceutical value of the peptide has been well demonstrated by its capacity to stimulate NK cytotoxic activity and interferon (IFN) synthesis in animal and human models, as well as to enhance antiviral and antitumor activities in ...
Cheolju Lee +2 more
exaly +4 more sources
Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model
International Immunopharmacology, 2012Alloferons are a group of antiviral and anti-tumor peptides primarily isolated from insects and stimulating cytotoxic activity of natural killer cells in mammals including mice and humans. Alloferon-1 is currently used in the treatment of persistent viral infections; however its anti-tumor potential needs further preclinical assessment.
Sergey Chernysh
exaly +3 more sources
Novel analogs of alloferon: Synthesis, conformational studies, pro-apoptotic and antiviral activity
Bioorganic Chemistry, 2016In this study, we report the structure-activity relationships of novel derivatives of the insect peptide alloferon (H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH). The peptide structure was modified by exchanging His at position 9 or 12 for natural or non-natural amino acids.
Kuczer, Mariola +5 more
openaire +2 more sources
Studies of insect peptides alloferon, Any‐GS and their analogues. Synthesis and antiherpes activity
Journal of Peptide Science, 2010AbstractThe subject of these studies was synthesis and determination of biological properties of a series of insect peptides, such as alloferon, Any‐GS and their analogues. The synthesis of 14 peptides was performed by the solid‐phase method. Biological effect of these peptides was evaluated by the antiviral test against Human Herpes Virus type 1 (HHV ...
Kuczer, Mariola +5 more
openaire +2 more sources
Biochemical blood parameters of patients with aleutian mink disease under the influence of alloferon
International Journal of Veterinary Medicine, 2023Fur farming in Russia can be considered one of the most profitable industries. However, outbreaks of infectious diseases in animal farms, in the difficult conditions of the global financial crisis, cause irreparable economic damage, which negatively affects the prospects for the development of the industry.
A. A. Sukhinin, M. M. Gumberidze
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Novel biological effects of alloferon and its selected analogues: Structure–activity study
Regulatory Peptides, 2013The subject of this paper is a search for new biological properties of alloferon (H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH) and a series of its analogues. The studies on structure/activity relationship in alloferon, the synthesis of a series of 28 analogues were performed.
Mariola, Kuczer +2 more
openaire +2 more sources
The long‐term immunological effects of alloferon and its analogues in the mealworm Tenebrio molitor
Insect Science, 2017AbstractThe subject of this article is a search for the long‐term immunological effects of alloferon and 3 structural analogues of alloferon, which were earlier characterized by the highest pro‐apoptotic activity in Tenebrio molitor. The differences in the actions of these peptides on immune response were observed.
Elżbieta, Czarniewska +3 more
openaire +2 more sources
Journal of Inorganic Biochemistry, 2009
Mononuclear copper(II) complexes of the alloferon 1 His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly, alloferon 2 Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly, Ac-alloferon 1 Ac-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly and Ac-alloferon 2 Ac-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly have been studied by potentiometric, UV-vis, CD ...
Teresa, Kowalik-Jankowska +3 more
openaire +2 more sources
Mononuclear copper(II) complexes of the alloferon 1 His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly, alloferon 2 Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly, Ac-alloferon 1 Ac-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly and Ac-alloferon 2 Ac-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly have been studied by potentiometric, UV-vis, CD ...
Teresa, Kowalik-Jankowska +3 more
openaire +2 more sources
Dalton Transactions, 2010
Complex formation processes between the SGH(3)GQH(6)GVH(9)G decapeptide fragment of alloferons 1 and 2 and copper(II) ions have been studied by potentiometric, UV-vis, circular dichroism (CD) and electron paramagnetic resonance (EPR) methods. This peptide contains two histidines (H(6) and H(9)) and an N-terminal "albumin-like" Xaa-Yaa-His sequence.
Teresa, Kowalik-Jankowska +2 more
openaire +2 more sources
Complex formation processes between the SGH(3)GQH(6)GVH(9)G decapeptide fragment of alloferons 1 and 2 and copper(II) ions have been studied by potentiometric, UV-vis, circular dichroism (CD) and electron paramagnetic resonance (EPR) methods. This peptide contains two histidines (H(6) and H(9)) and an N-terminal "albumin-like" Xaa-Yaa-His sequence.
Teresa, Kowalik-Jankowska +2 more
openaire +2 more sources