Results 131 to 140 of about 307,259 (361)

Disorders of endocrine, reproductive and skeletal systems following allogeneic or autologous stem cell transplantation for hematological malignancies in adults

, 2006
Introduzione Il progressivo aumento del numero dei pazienti sopravviventi a lungo termine dopo la guarigione da malignità emopoietiche ha portato a focalizzare l’attenzione sulle complicanze precoci e tardive delle malattie e dei loro trattamenti.
Tauchmanova, Libuse
core  

Real-World Selection of Patients for Allogeneic HCT at a Single Centre: Lack of a Suitable Donor and Other Reasons for Not Proceeding

Current Oncology
The reasons why patients cannot proceed with HCT, including cases where no suitable donor is identified, remain poorly described. We reviewed all referrals for allogeneic HCT to our programme between 1 January 2019 and 31 December 2023.
Madeline Monaghan, An Duong, Kalina Abrol, Trang Doan, Carolina Cieniak, Harold Atkins, Natasha Kekre, Ashish Masurekar, Ram Vasudevan Nampoothiri, Santhosh Thyagu, Christopher N. Bredeson, Michael Kennah, David S. Allan   +12 more
doaj   +1 more source

Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study

Cell Research, 2022
Yong-xian Hu, Yali Zhou, Mingming Zhang, Houli Zhao, G. Wei, Wengang Ge, Q. Cui, Qi-tian Mu, Gong Chen, Luwei Han, Tingting Guo, Jiazhen Cui, Xiaoyan Jiang, Xiujun Zheng, Shuhui Yu, Xiaolong Li, Xingwang Zhang, Mingxi Chen, Xiujuan Li, M. Gao, Kangyan Wang, Cheng Zu, Hao Zhang, Xiao-peng He, Yanbin Wang, Dongrui Wang, Jiangtao Ren, He Huang   +27 more
semanticscholar   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Development of a sample bank and clinical database for the retrospective analysis of unrelated bone marrow transplants: a pilot study of 138 transplants using RSCA for high resolution HLA matching.

, 2005
The Anthony Nolan Register provides donors for allogeneic stem cell transplantation for haematological disorders. A clinical database and sample bank were established for the ongoing analysis of transplants from Register donors.
Pay, A.L.P.
core  

Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cells

Frontiers in Immunology
BackgroundInduced pluripotent stem cells (iPSCs) are a promising platform to produce “off-the-shelf” chimeric antigen receptor (CAR)-engineered T cells (CAR-T) with thepotential for multiplex genetic engineering.MethodsHere, we employed genome editing to
Alexandros Nianias, Alexandros Nianias, Afroditi Katsarou, Afroditi Katsarou, Henk Jan Prins, Henk Jan Prins, Aida Shahrabi, Aida Shahrabi, Cindy van Velzen, Cindy van Velzen, Linda Henneman, Ruud Ruiter, Ruud Ruiter, Tuna Mutis, Tuna Mutis, Richard Groen, Richard Groen, Maria Themeli, Maria Themeli   +18 more
doaj   +1 more source

Phase 1 Trial With the Cell-Based Immune Primer Ilixadencel, Alone, and Combined With Sorafenib, in Advanced Hepatocellular Carcinoma

Frontiers in Oncology, 2019
Several lines of evidence support immunotherapy in hepatocellular carcinoma (HCC). We have shown that intratumoral injections of the immune primer ilixadencel (pro-inflammatory allogeneic dendritic cells) are safe in renal-cell carcinoma.
Magnus Rizell, Magnus Rizell, Malin Sternby Eilard, Malin Sternby Eilard, Mats Andersson, Mats Andersson, Bengt Andersson, Alex Karlsson-Parra, Alex Karlsson-Parra, Peter Suenaert   +9 more
doaj   +1 more source

Ipilimumab for Patients with Relapse after Allogeneic Transplantation

New England Journal of Medicine, 2016
BACKGROUND Loss of donor-mediated immune antitumor activity after allogeneic hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers.
M. Davids, Haesook T. Kim, P. Bachireddy, Caitlin L. Costello, R. Liguori, A. Savell, Alexander P. Lukez, D. Avigan, Yi-Bin Chen, P. Mcsweeney, N. Leboeuf, Michael S. Rooney, M. Bowden, C. Zhou, S. Granter, J. Hornick, Scott J Rodig, M. Hirakawa, Mariano Severgnini, F. Hodi, Catherine J. Wu, V. Ho, C. Cutler, J. Koreth, E. P. Alyea, J. Antin, P. Armand, Howard Streicher, Edward D. Ball, Jerome Ritz, A. Bashey, R. Soiffer   +31 more
semanticscholar   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source