Results 121 to 130 of about 307,259 (361)

Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificity [PDF]

, 1993
The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we
Connolly, J. M., Koszinowski, Ulrich H., Alexander-Miller, M. A., Burke, K., Hansen, T. H.   +4 more
core  

Allogeneic cell therapy for osteoarthritis

, 2016
Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote cartilage healing is urgently ...
Lohan, Paul
core   +1 more source

The Role of Anti-Thymocyte Globulin or Alemtuzumab-Based Serotherapy in the Prophylaxis and Management of Graft-Versus-Host Disease

Biomedicines, 2017
Allogeneic hematopoietic stem cell transplant is an established treatment modality for hematologic and non-hematologic diseases. However, it is associated with acute and long-term sequelae which can translate into mortality.
Robert Ali, Jeremy Ramdial, Sandra Algaze, Amer Beitinjaneh   +3 more
doaj   +1 more source

The Importance of HLA Assessment in “Off-the-Shelf” Allogeneic Mesenchymal Stem Cells Based-Therapies

International Journal of Molecular Sciences, 2019
The need for more effective therapies of chronic and acute diseases has led to the attempts of developing more adequate and less invasive treatment methods. Regenerative medicine relies mainly on the therapeutic potential of stem cells.
M. Kot, M. Baj-Krzyworzeka, R. Szatanek, Aleksandra Musiał-Wysocka, Magdalena Suda-Szczurek, M. Majka   +5 more
semanticscholar   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Dissecting Allo-Sensitization After Local Administration of Human Allogeneic Adipose Mesenchymal Stem Cells in Perianal Fistulas of Crohn's Disease Patients

Frontiers in Immunology, 2019
Adipose mesenchymal stem cells (ASC) are considered minimally immunogenic. This is due to the low expression of human leukocyte antigens I (HLA-I), lack of HLA-II expression and low expression of co-stimulatory molecules such as CD40 and CD80.
Alvaro Avivar-Valderas, Cristina Martín-Martín, Cristina Ramírez, Borja Del Río, Ramón Menta, Pablo Mancheño-Corvo, Maitane Ortiz-Virumbrales, Ángel Herrero-Méndez, Julián Panés, Damián García-Olmo, José Luís Castañer, Itziar Palacios, Eleuterio Lombardo, Wilfried Dalemans, Olga DelaRosa   +14 more
doaj   +1 more source

Comparison of Allogeneic vs Autologous Bone Marrow–Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients With Ischemic Cardiomyopathy

Journal of the American Medical Association (JAMA), 2012
Context Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; however, their safety and efficacy have not been compared.
J. Hare, J. Fishman, G. Gerstenblith, Darcy L DiFede Velazquez, J. Zambrano, V. Suncion, M. Tracy, E. Ghersin, Peter V. Johnston, J. Brinker, Elayne Breton, J. Davis-Sproul, I. Schulman, J. Byrnes, A. Mendizabal, M. Lowery, D. Rouy, Peter A. Altman, Cheryl Wong Po Foo, P. Ruiz, Alexandra Amador, José da Silva, I. Mcniece, A. Heldman   +23 more
semanticscholar   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

In utero transplantation of autologous and allogeneic fetal liver stem cells in ovine fetuses

, 2004
OBJECTIVE: The purpose of this study was to assess the feasibility of autologous stem cell transplantation in fetal sheep and to compare short-term engraftment of allogeneic and autologous fetal liver stem cells in an immunocompetent large animal model ...
Holzgreve, W, Schoeberlein, A, Hahn, S, Dudler, L, Surbek, DV   +4 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source