Results 101 to 110 of about 307,259 (361)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Baseline allogeneic HCT patient characteristics.

, 2022
Baseline allogeneic HCT patient characteristics.
Julie Miller (2948109), Meagan Lew (12501639), Mark G. Shrime (3609239), Sharareh Siamakpour-Reihani (218652), Amy T. Bush (12501642), Nelson J. Chao (9368078), Jillian C. Thompson (12501636), Kristi Romero (6205946), Julia A. Messina (12501645), Yi Ren (30049), Jonathan U. Peled (11028035), Robert R. Jenq (10321546), Marcel R. M. van den Brink (12501648), Anthony D. Sung (6205916), Sin-Ho Jung (3168027)   +14 more
core   +1 more source

Translational Clinical Research: Use of Allogeneic Platelet-Rich Fibrin (PRF) for Wound Regeneration in Two Small-Sized Dogs

Animals
Platelet-rich fibrin (PRF) is a recent regenerative biomaterial applied in clinical wound healing. This study aims to evaluate the safety and efficacy of allogeneic PRF therapy as a regenerative methodology for treating skin wounds in two small dogs.
Carla S. Soares, Isabel R. Dias, Luís C. Barros, Pedro P. Carvalho, Maria dos Anjos Pires   +4 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation

, 2020
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.

core   +2 more sources

In vitro testing of immunosupressive effects of mesenchymal stromal cells on lymphocytes stimulated with alloantigens

Biomedical Papers, 2015
Aims: Mesenchymal stromal cells (MSC) derived from adult bone marrow or adipose tissue offer the potential to open a new frontier in medicine. MSC are involved in modulating immune response and tissue repair in vitro and in vivo.
Daniel Lysak, Tomas Vlas, Monika Holubova, Michaela Miklikova, Pavel Jindra   +4 more
doaj   +1 more source

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

Science Translational Medicine, 2016
Treating neutropenic fever with broad-spectrum antibiotics after allogeneic hematopoietic stem cell transplant is associated with an increase in graft-versus-host disease in mice and humans.
Y. Shono, Melissa Docampo, J. Peled, S. M. Perobelli, E. Velardi, J. Tsai, Ann E. Slingerland, O. Smith, L. Young, J. Gupta, Sophia R Lieberman, Hillary V. Jay, Katya Ahr, Kori A. Porosnicu Rodriguez, Ke Xu, Marco Calarfiore, Hendrik Poeck, S. Caballero, S. Devlin, Franck Rapaport, J. Dudakov, A. Hanash, B. Gyurkocza, G. Murphy, C. Gomes, Chen Liu, Eli Moss, S. Falconer, A. Bhatt, Y. Taur, E. Pamer, M. V. D. van den Brink, R. Jenq   +32 more
semanticscholar   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Impact of hospital length of stay on the risk of readmission and overall survival after allogeneic stem cell transplantation [PDF]

, 2018
Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at high risk of readmission for complications. We sought to examine the association between HSCT hospital length of stay and the incidence of readmission and survival ...
Kawashima, Naomi, Atsuta, Yoshiko, Ozawa, Yukiyasu, Miyamura, Koichi, Kiyoi, Hitoshi, Seto, Aika   +5 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source