Results 91 to 100 of about 265,496 (312)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

O transplante de células-tronco hematopoéticas como opção no tratamento de doenças não hematológicas Hematopoietic stem cell transplant: a therapeutic option for non-hematologic diseases

Revista Brasileira de Hematologia e Hemoterapia, 2009
Nesta revisão são abordadas as doenças em que existem dados e perspectivas do uso de transplante de células-tronco hematopoéticas em suas diversas modalidades.
Milton A. Ruiz, Lilian Piron-Ruiz, Mario R. Lago, Angelo Maset, Adriana B. Santos, Oswaldo T. Greco   +5 more
doaj   +1 more source

Microchimerism, dendritic cell progenitors and transplantation tolerance [PDF]

, 1995
The recent discovery of multilineage donor leukocyte microchimerism in allograft recipients up to three decades after organ transplantation implies the migration and survival of donor stem cells within the host.
Demetris, AJ, Lu, L, Murase, N, Rao, AS, Starzl, TE, Thomson, AW   +5 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The Role of Anti-Thymocyte Globulin or Alemtuzumab-Based Serotherapy in the Prophylaxis and Management of Graft-Versus-Host Disease

Biomedicines, 2017
Allogeneic hematopoietic stem cell transplant is an established treatment modality for hematologic and non-hematologic diseases. However, it is associated with acute and long-term sequelae which can translate into mortality.
Robert Ali, Jeremy Ramdial, Sandra Algaze, Amer Beitinjaneh   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Corrigendum: Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT)

Frontiers in Neuroscience, 2023
Thanh G. Phan, Thanh G. Phan, Rebecca Lim, Rebecca Lim, Mirja Krause, Mirja Krause, Siow T. Chan, Siow T. Chan, Hannah McDonald, Hannah McDonald, Poh-Yi Gan, Poh-Yi Gan, Shenpeng R. Zhang, Liz J. Barreto Arce, Jason Vuong, Jason Vuong, Tharani Thirugnanachandran, Tharani Thirugnanachandran, Benjamin Clissold, Benjamin Clissold, John Ly, John Ly, Shaloo Singhal, Shaloo Singhal, Marie Veronic Hervet, Marie Veronic Hervet, Hyun Ah Kim, Grant R. Drummond, Euan M. Wallace, Euan M. Wallace, Henry Ma, Henry Ma, Christopher G. Sobey   +32 more
doaj   +1 more source

Dissecting Allo-Sensitization After Local Administration of Human Allogeneic Adipose Mesenchymal Stem Cells in Perianal Fistulas of Crohn's Disease Patients

Frontiers in Immunology, 2019
Adipose mesenchymal stem cells (ASC) are considered minimally immunogenic. This is due to the low expression of human leukocyte antigens I (HLA-I), lack of HLA-II expression and low expression of co-stimulatory molecules such as CD40 and CD80.
Alvaro Avivar-Valderas, Cristina Martín-Martín, Cristina Ramírez, Borja Del Río, Ramón Menta, Pablo Mancheño-Corvo, Maitane Ortiz-Virumbrales, Ángel Herrero-Méndez, Julián Panés, Damián García-Olmo, José Luís Castañer, Itziar Palacios, Eleuterio Lombardo, Wilfried Dalemans, Olga DelaRosa   +14 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source