Results 91 to 100 of about 307,259 (361)

Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease [PDF]

, 2014
Allogeneic haematopoietic stem cell transplantation (HSCT) is the standard therapy for many disorders of the haematological system. Its use is limited by the major complication acute graft-versus-host disease (GVHD). Development of acute GVHD predisposes
Dertschnig, Simone
core   +1 more source

The systemic cellular immune response against allogeneic mesenchymal stem cells is influenced by inflammation, differentiation and MHC compatibility: in vivo study in the horse

Frontiers in Veterinary Science
The effectiveness and safety of allogeneic mesenchymal stem/stromal cells (MSCs) can be affected by patient’s immune recognition. Thus, MSC immunogenicity and their immunomodulatory properties are crucial aspects for therapy.
Alina Cequier, Alina Cequier, Francisco José Vázquez, Francisco José Vázquez, Arantza Vitoria, Arantza Vitoria, Elvira Bernad, Sara Fuente, Sara Fuente, María Belén Serrano, María Pilar Zaragoza, Antonio Romero, Antonio Romero, Clementina Rodellar, Laura Barrachina, Laura Barrachina   +15 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Allogeneic Transplant for CMML

Current Hematologic Malignancy Reports
Abstract Purpose of Review Chronic myelomonocytic leukemia (CMML) is a rare hematologic malignancy at the intersection of myelodysplastic (MDS) and myeloproliferative neoplasms, predominantly affecting older adults.
Gagelmann, Nico, Desai, Nihar
openaire   +2 more sources

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

Molecular Therapy, 2017
Adoptive cellular therapy using chimeric antigen receptor (CAR) T cell therapies have produced significant objective responses in patients with CD19+ hematological malignancies, including durable complete responses.
Daniel T Macleod, J. Antony, Aaron J Martin, R. Moser, A. Hekele, K. Wetzel, A. Brown, Melissa A. Triggiano, Jo Ann Hux, C. Pham, V. Bartsevich, Caitlin Turner, J. Lape, Samantha Kirkland, C. Beard, Jeff Smith, M. Hirsch, Michael G. Nicholson, D. Jantz, B. McCreedy   +19 more
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution

, 2002
Nonmyeloablative conditioning is increasingly used for transplantation in a wide range of diseases, but little is known about its impact on the incidence of infections and immune reconstitution.
Mahendra, P, Marshall, T, O'Gorman, P, Osman, H., Chakraverty, R, Hale, G., Osman, H, Peggs, K., O'Gorman, P., Mahendra, Premini, Mackinnon, S, Fegan, Christopher, Chopra, Ravinder, Linch, DC, Goldstone, A.H., Chopra, R, Waldmann, H., Milligan, D.W., Chakrabarti, Suparno, Hale, G, Chakrabarti, S., Marshall, T., Chakrabarti, S, Peggs, K, Chakraverty, Ronjon, Chopra, R., Waldmann, H, Kottaridis, P.D., Craddock, C., Milligan, DW, Mackinnon, S., Chakraverty, R., Kottaridis, PD, Yong, K., Kottaridis, P, Milligan, Donald, Mahendra, P., Craddock, Charles; id_orcid, Craddock, C, Yong, K, Goldstone, AH, Waldmann, Herman, Fegan, CD, Fegan, C.D., Linch, D.C.   +44 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Allogeneic hematopoietic cell transplantation in the management of GATA2 deficiency and pulmonary alveolar proteinosis.

, 2020
Human hematopoiesis is critically dependent on the transcription factor GATA2. Patients with GATA2 deficiency typically present with myelodysplastic syndrome, reduced numbers of monocytes, NK cells and B cells, and/or opportunistic infections.
Rutten, Caroline E, Jonkers, René E., Hazenberg, Mette D., ten Berge, Ineke J. M., van Lier, Yannouck F., Rutten, Caroline E., Kuijpers, Taco W., de Bree, Godelieve J., van Lier, Yannouck F, Jonkers, René E, de Bree, Godelieve J, Roelofs, Joris J. T. H., Hazenberg, Mette D, Roelofs, Joris J T H, Ten Berge, Ineke J M, Nur, Erfan, Kuijpers, Taco W, Zeerleder, Sacha S.   +17 more
core   +1 more source

Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

Frontiers in Medicine
IntroductionLow back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation.
Chen Chen, Yizhuo Huang, Lei Shi, Li Zhou, Shenao Zhou, Shenao Zhou, Hongjin Wan, Xiao Yang, Jie Zhao   +8 more
doaj   +1 more source