Results 71 to 80 of about 307,259 (361)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Development of methods for the in-vitro assessment of the adipogenesis and immunogenicity of human multipotent mesenchymal stromal cells [PDF]

, 2011
Adult mesenchymal stromal cells (MSCs) have enormous potential in tissue engineering and regenerative medicine applications. MSC have also been reported to be immune-privileged.
Aldridge, Andrew Robert
core  

Transforming Growth Factor-β2 Downregulates Major Histocompatibility Complex (MHC) I and MHC II Surface Expression on Equine Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Other Phenotypic Cell Surface Markers

Frontiers in Veterinary Science, 2017
Allogeneic mesenchymal stem cells (MSCs) are a promising cell source for treating musculoskeletal injuries in horses. Effective and safe allogeneic therapy may be hindered, however, by recipient immune recognition and rejection of major ...
Alix K. Berglund, Alix K. Berglund, Matthew B. Fisher, Matthew B. Fisher, Kristin A. Cameron, Emma J. Poole, Lauren V. Schnabel, Lauren V. Schnabel   +7 more
doaj   +1 more source

Natural Killer Cells as Allogeneic Effectors in Adoptive Cancer Immunotherapy

Cancers, 2019
Natural killer (NK) cells are attractive within adoptive transfer settings in cancer immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced under conditions of killer immunoglobulin-like receptor (KIR) mismatch with ...
Kyle B. Lupo, S. Matosevic
semanticscholar   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The EBMT activity survey report 2017: a focus on allogeneic HCT for nonmalignant indications and on the use of non-HCT cell therapies

Bone Marrow Transplantation, 2019
Hematopoietic cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants done in Europe and associated countries continues to rise with 45,418 HCT in 41,100 patients [(17,155 ...
J. Passweg, H. Baldomero, G. Basak, C. Chabannon, S. Corbacioglu, R. Duarte, J. Kuball, A. Lankester, S. Montoto, R. D. de Latour, J. Snowden, J. Styczyński, I. Yakoub-Agha, M. Arat, M. Mohty, N. Kröger   +15 more
semanticscholar   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement.

, 2013
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP.
Bax, BE, Tonin, P, Bax B. E., Moran N., SCARPELLI, Mauro, Tonin P., Scarpelli M., Filosto M., Bain, MD, TONIN, PAOLA, Scarpelli, M, Filosto, M, Moran, N, Bain M. D.   +13 more
core   +1 more source

Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers [PDF]

, 2005
Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant ...
Premini Mahendra, Craddock, Charles., McDonald, D, Billingham, Lucinda, Steward, Colin, Dorothy McDonald, Pourgheysari, Batoul, Eduardo Olavarria, Mahendra, Premini, Assenmacher, Mario., Olavarria, Eduardo, Tauro, Sudhir, Chakraverty, Ronjon., Goldman, John, Cobbold, Mark., Moss, Paul; id_orcid, Steward, Colin., McDonald, Dorothy, Pourgheysari Najafabadi, Batoul, John Goldman, Ronjon Chakraverty, Chakraverty, Ronjon, Crawley, Charles, Colin Steward, Billingham, Lucinda; id_orcid, Craddock, Charles; id_orcid, Assenmacher, Mario, Goldman, J, Pourgheysari, Batoul., Billingham, Lucinda., Tauro, S, Crawley, Charles., Charles Crawley, Osman, H, Batoul Pourgheysari, Naeem Khan, Mario Assenmacher, Osman, Husam, Assenmacher, M, Khan, Naeem, Goldman, John., Craddock, Charles, Mark Cobbold, Steward, C, McDonald, Dorothy., Olavarria, Eduardo., Olavarria, E, Husam Osman, Cobbold, Mark, Crawley, C, Osman, Husam., Mahendra, Premini., Sudhir Tauro, Tauro, Sudhir., Charles Craddock, Moss, Paul A. H., Moss, Paul A H, Khan, Naeem., Lucinda Billingham, Paul A.H. Moss, Moss, Paul A.H.   +60 more
core   +1 more source