Results 71 to 80 of about 193,019 (302)

Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation Práticas recomendadas para triagem e prevenção de complicações em sobreviventes de longo prazo após transplante de células hematopoéticas

Revista Brasileira de Hematologia e Hemoterapia, 2012
Advances in hematopoietic cell transplantation (HCT) technology and supportive care techniques have led to improvements in long-term survival after HCT. Emerging indications for transplantation, introduction of newer graft sources (e.g.
Navneet Singh Majhail, James Douglas Rizzo, Stephanie Joi Lee, Mahmoud Aljurf, Yoshiko Atsuta, Carmem Bonfim, Linda Jean Burns, Naeem Chaudhri, Stella Davies, Shinichiro Okamoto, Adriana Seber, Gerard Socie, Jeff Szer, Maria Teresa Van Lint, John Reid Wingard, Andre Tichelli   +15 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution [PDF]

, 2002
Nonmyeloablative conditioning is increasingly used for transplantation in a wide range of diseases, but little is known about its impact on the incidence of infections and immune reconstitution.
Mahendra, P, Marshall, T, O'Gorman, P, Osman, H., Chakraverty, R, Hale, G., Osman, H, Peggs, K., O'Gorman, P., Mahendra, Premini, Mackinnon, S, Fegan, Christopher, Chopra, Ravinder, Linch, DC, Goldstone, A.H., Chopra, R, Waldmann, H., Milligan, D.W., Chakrabarti, Suparno, Hale, G, Chakrabarti, S., Marshall, T., Chakrabarti, S, Peggs, K, Chakraverty, Ronjon, Chopra, R., Waldmann, H, Kottaridis, P.D., Craddock, C., Milligan, DW, Mackinnon, S., Chakraverty, R., Kottaridis, PD, Yong, K., Kottaridis, P, Milligan, Donald, Mahendra, P., Craddock, Charles; id_orcid, Craddock, C, Yong, K, Goldstone, AH, Waldmann, Herman, Fegan, CD, Fegan, C.D., Linch, D.C.   +44 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Allogeneic hematopoietic cell transplantation in the management of GATA2 deficiency and pulmonary alveolar proteinosis. [PDF]

, 2020
Human hematopoiesis is critically dependent on the transcription factor GATA2. Patients with GATA2 deficiency typically present with myelodysplastic syndrome, reduced numbers of monocytes, NK cells and B cells, and/or opportunistic infections.
Rutten, Caroline E, Jonkers, René E., Hazenberg, Mette D., ten Berge, Ineke J. M., van Lier, Yannouck F., Rutten, Caroline E., Kuijpers, Taco W., de Bree, Godelieve J., van Lier, Yannouck F, Jonkers, René E, de Bree, Godelieve J, Roelofs, Joris J. T. H., Hazenberg, Mette D, Roelofs, Joris J T H, Ten Berge, Ineke J M, Nur, Erfan, Kuijpers, Taco W, Zeerleder, Sacha S.   +17 more
core   +1 more source

Real-World Selection of Patients for Allogeneic HCT at a Single Centre: Lack of a Suitable Donor and Other Reasons for Not Proceeding

Current Oncology
The reasons why patients cannot proceed with HCT, including cases where no suitable donor is identified, remain poorly described. We reviewed all referrals for allogeneic HCT to our programme between 1 January 2019 and 31 December 2023.
Madeline Monaghan, An Duong, Kalina Abrol, Trang Doan, Carolina Cieniak, Harold Atkins, Natasha Kekre, Ashish Masurekar, Ram Vasudevan Nampoothiri, Santhosh Thyagu, Christopher N. Bredeson, Michael Kennah, David S. Allan   +12 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cells

Frontiers in Immunology
BackgroundInduced pluripotent stem cells (iPSCs) are a promising platform to produce “off-the-shelf” chimeric antigen receptor (CAR)-engineered T cells (CAR-T) with thepotential for multiplex genetic engineering.MethodsHere, we employed genome editing to
Alexandros Nianias, Alexandros Nianias, Afroditi Katsarou, Afroditi Katsarou, Henk Jan Prins, Henk Jan Prins, Aida Shahrabi, Aida Shahrabi, Cindy van Velzen, Cindy van Velzen, Linda Henneman, Ruud Ruiter, Ruud Ruiter, Tuna Mutis, Tuna Mutis, Richard Groen, Richard Groen, Maria Themeli, Maria Themeli   +18 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source