Results 61 to 70 of about 193,019 (302)

Allogeneic Transplant for CMML

Current Hematologic Malignancy Reports
Abstract Purpose of Review Chronic myelomonocytic leukemia (CMML) is a rare hematologic malignancy at the intersection of myelodysplastic (MDS) and myeloproliferative neoplasms, predominantly affecting older adults.
Gagelmann, Nico, Desai, Nihar
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement. [PDF]

, 2013
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP.
Bax, BE, Tonin, P, Bax B. E., Moran N., SCARPELLI, Mauro, Tonin P., Scarpelli M., Filosto M., Bain, MD, TONIN, PAOLA, Scarpelli, M, Filosto, M, Moran, N, Bain M. D.   +13 more
core   +1 more source

Transforming Growth Factor-β2 Downregulates Major Histocompatibility Complex (MHC) I and MHC II Surface Expression on Equine Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Other Phenotypic Cell Surface Markers

Frontiers in Veterinary Science, 2017
Allogeneic mesenchymal stem cells (MSCs) are a promising cell source for treating musculoskeletal injuries in horses. Effective and safe allogeneic therapy may be hindered, however, by recipient immune recognition and rejection of major ...
Alix K. Berglund, Alix K. Berglund, Matthew B. Fisher, Matthew B. Fisher, Kristin A. Cameron, Emma J. Poole, Lauren V. Schnabel, Lauren V. Schnabel   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Evaluation of the Effect of a Single Intra-articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells Compared to Oral Non-Steroidal Anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau Leveling Osteotomy: A Pilot Study

Frontiers in Veterinary Science, 2017
ObjectiveCompare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs
Mathieu Taroni, Quentin Cabon, Quentin Cabon, Marine Fèbre, Thibaut Cachon, Thibaut Cachon, Nathalie Saulnier, Claude Carozzo, Claude Carozzo, Stéphane Maddens, Fabrice Labadie, Clément Robert, Eric Viguier, Eric Viguier   +13 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Disorders of endocrine, reproductive and skeletal systems following allogeneic or autologous stem cell transplantation for hematological malignancies in adults [PDF]

, 2006
Introduzione Il progressivo aumento del numero dei pazienti sopravviventi a lungo termine dopo la guarigione da malignità emopoietiche ha portato a focalizzare l’attenzione sulle complicanze precoci e tardive delle malattie e dei loro trattamenti.
Tauchmanova, Libuse
core   +1 more source

The systemic cellular immune response against allogeneic mesenchymal stem cells is influenced by inflammation, differentiation and MHC compatibility: in vivo study in the horse

Frontiers in Veterinary Science
The effectiveness and safety of allogeneic mesenchymal stem/stromal cells (MSCs) can be affected by patient’s immune recognition. Thus, MSC immunogenicity and their immunomodulatory properties are crucial aspects for therapy.
Alina Cequier, Alina Cequier, Francisco José Vázquez, Francisco José Vázquez, Arantza Vitoria, Arantza Vitoria, Elvira Bernad, Sara Fuente, Sara Fuente, María Belén Serrano, María Pilar Zaragoza, Antonio Romero, Antonio Romero, Clementina Rodellar, Laura Barrachina, Laura Barrachina   +15 more
doaj   +1 more source