Results 41 to 50 of about 193,019 (302)

HLA-mismatched allogeneic adoptive immune therapy in patients with severely immunosuppressed AIDS: a multicenter, open-label, controlled, phase 2a study

Emerging Microbes and Infections
Recurrent opportunistic infections (OIs) in patients with severely immunosuppressed AIDS remain an unresolved medical challenge despite advancements in antiretroviral therapy (ART).
Tao Yang, Zhiman Xie, Zhe Xu, Bo Tu, Huan Lu, Huihuang Huang, Lei Huang, Chao Zhang, Liying Gao, Lei Jin, Ping Ma, Jun Zou, Limin Liu, Cheng Zhen, Chunbao Zhou, Sirun Meng, Yuan-Yuan Li, Jin-Wen Song, Shixiong Yang, Hui-Sheng Ai, Yanmei Jiao, Ming Shi, Ruonan Xu, Fu-Sheng Wang   +23 more
doaj   +1 more source

Commercial Scale Manufacturing of Allogeneic Cell Therapy

Frontiers in Medicine, 2018
Allogeneic cell therapy products are generating encouraging clinical and pre-clinical results. Pluripotent stem cell (PSC) derived therapies, in particular, have substantial momentum and the potential to serve as treatments for a wide range of ...
Gary M. Pigeau, Gary M. Pigeau, Elizabeth Csaszar, Elizabeth Csaszar, Aaron Dulgar-Tulloch, Aaron Dulgar-Tulloch   +5 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Patient reported outcomes in view of symptom experience of late effects and self-management of adult long-term survivors after allogeneic haematopoietic stem cell transplantation - a mixed methods study [PDF]

, 2014
Even years after allogeneic stem cell transplantation, recipients face a continuing risk of developing serious late effects. Previous studies have focused on the pathophysiological understanding of late effects, as well as on treatment and disease ...
Kirsch, Monika
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Decreased HIV diversity after allogeneic stem cell transplantation of an HIV-1 infected patient : a case report [PDF]

, 2010
The human immunodeficiency virus type 1 (HIV-1) coreceptor use and viral evolution were analyzed in blood samples from an HIV-1 infected patient undergoing allogeneic stem cell transplantation (SCT).
Bravo Ignacio G, Wolf, Timo, Schnierle Barbara S, Schnierle, Barbara S, Thielen, A., Krause, B., Werner, A., Schnierle, Barbara, Christel Kamp, Bravo, I., Winskowsky, Gudrun, Albrecht Werner, Neumann, B., Thielen, Alexander, Werner Albrecht, Krause Birgit, Kamp Christel, Timo Wolf, Wolf, T., Thielen Alexander, Winskowsky, G., Kraus, Benjamin, Wolf Timo, Werner, Albrecht, Gudrun Winskowsky, Alexander Thielen, Neumann, Britta, Birgit Krause, Bravo, Ignacio G., Neumann Britta, Kraus, B., Kamp, Christel, Kamp, C., Ignacio G Bravo, Barbara S Schnierle, Krause, Birgit, Bravo, Ignacio G, Winskowsky Gudrun, Kraus Benjamin, Britta Neumann, Schnierle, B., Benjamin Kraus   +41 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation:a Global Observational Study [PDF]

, 2013
Fifty-five years after publication of the first hematopoietic stem cell transplantation this technique has become an accepted treatment option for defined hematologic and non-hematologic disorders.
Madrigal, Alejandro, Horowitz, Mary, Passweg, Jakob, Bouzas, Luis Fernando, Szer, Jeff, Niederwieser, Dietger, Gratwohl, Alois, Aljurf, Mahmoud, Iida, Minako, Kodera, Yoshihisa, Worldwide Network Blood Marrow Tra, Pasquini, Marcelo C., Marrow Transplantation,, Lipton, Jeff, Worldwide Network of Blood,, Gratwohl, Michael, Baldomero, Helen, Frauendorfer, Karl   +17 more
core   +1 more source

The impact of heterotopic ovarian tissue transplantation with varied volumes on reproductive endocrine function in oophorectomized rats

Journal of Obstetrics and Gynaecology
Background This study aimed to investigate the effects of different volumes of ovarian tissue transplantation on the reproductive endocrine function of rats after oophorectomy.Methods Female rats were selected to establish a castration model and then ...
Nana Tian, Chunhui Liu, Zhihui Cai, Junrong Shi, Pin Li, Shasha Bai, Xiaoxin Du, Gaoyuan Liu, Min Geng, Peishan Weng   +9 more
doaj   +1 more source