Results 41 to 50 of about 307,259 (361)

Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy

Cancer immunology research, 2020
Antitumor T-cell grafts with HLA class I, HLA class II, and TCR molecules concurrently ablated evade allogeneic T-cell responses. These cells can be used as a universal T-cell source for adoptive cancer immunotherapy.
Yuki Kagoya, Tingxi Guo, B. Yeung, Kayoko Saso, M. Anczurowski, Chung-Hsi Wang, K. Murata, Kenji Sugata, H. Saijo, Yukiko Matsunaga, Y. Ohashi, M. Butler, N. Hirano   +12 more
semanticscholar   +1 more source

Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation

, 2012
Background: Reconstitution of cytomegalovirus-specific CD3+CD8+ T cells (CMV-CTLs) after allogeneic hematopoietic stem cell transplantation (HSCT) is necessary to bring cytomegalovirus (CMV) reactivation under control. However, the parameters determining
Matthias Eder (21135), Borchers, Sylvia, Benno Wölk, Sylvia Borchers, Arnold Ganser, Pabst, Brigitte, Mischak-Weissinger, Eva Maria, Michael Stadler, Elke Dammann, Andrea Jarisch, Lehrnbecher, Thomas, Arnold Ganser (4454), Eva M. Weissinger (111202), Meral Yildiz, Schneider, Gisbert, Matthias Eder, Peter Bader, Melanie Bremm (111153), Koehl, Ulrike, Thomas Klingebiel, Michael Stadler (111171), Ulrike Koehl, Hans Martin, Benno Wölk (111163), Stadler, Michael, Thomas Lehrnbecher, Sylvia Borchers (111150), Wölk, Benno, Hans Martin (111179), Meral Yildiz (111168), Dammann, Elke, Thomas Klingebiel (111191), Brigitte Pabst (111160), Bader, Peter, Eder, Matthias, Jarisch, Andrea, Brigitte Pabst, Gisbert Schneider, Elke Dammann (111158), Gisbert Schneider (17096), Ulrike Koehl (111209), Thomas Lehrnbecher (111156), Klingebiel, Thomas, Esser, Ruth, Eva M. Weissinger, Ruth Esser (111165), Ganser, Arnold, Yildiz, Meral, Melanie Bremm, Peter Bader (111174), Eva M Weissinger, Bremm, Melanie, Andrea Jarisch (111185), Ruth Esser, Weissinger, Eva M., Köhl, Ulrike, Martin, Hans   +56 more
core   +1 more source

Intrathecal cytomegalovirus immunoglobulin for CMV encephalitis post allogeneic stem cell transplantation

IDCases, 2022
We report the outcome of a 43 year old man who developed fatal ventriculoencephalitis due to cytomegalovirus (CMV) infection 7 months post allogeneic stem cell transplant.
Ian Pang, Sanjay Singhabahu, Igor Novitzky-Basso, Tony Mazzulli, Shahid Husain, Jonas Mattsson   +5 more
doaj   +1 more source

Allogeneic CAR-T Therapy Technologies: Has the Promise Been Met?

Cells
This last decade, chimeric antigen receptor (CAR) T-cell therapy has become a real treatment option for patients with B-cell malignancies, while multiple efforts are being made to extend this therapy to other malignancies and broader patient populations.
Caroline Lonez, E. Breman
semanticscholar   +1 more source

Hematopoietic chimerism after allogeneic stem cell transplantation : a comparison of quantitative analysis by automated DNA sizing and fluorescent in situ hybridization

, 2005
Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed mainly in patients with high-risk or advanced hematologic malignancies and congenital or acquired aplastic anemias.
Wachowiak, Jacek, Tomasz Strabel, Peter Bader, Bader, Peter, Jólkowska, Justyna, Jacek Wachowiak, Michał Witt, Anna Pieczonka, Strabel, Tomasz, Pieczonka, Anna, Dariusz Boruczkowski, Boruczkowski, Dariusz, Justyna Jółkowska, Witt, Michal   +13 more
core   +1 more source

Mechanisms of Resistance to CAR T-Cells and How to Overcome Them

Methods and Protocols
In the last few decades, chimeric antigen receptor (CAR) T-cell therapy has led to a paradigm shift in the treatment of hematological malignancies, including various subtypes of B-cell non-Hodgkin’s lymphoma, B-cell acute lymphoblastic leukemia, and ...
Luca Legato, Matteo Bisio, Filippo Fasano, Corrado Benevolo Savelli, Carolina Secreto, Chiara Maria Dellacasa, Barbara Botto, Alessandro Busca, Marco Cerrano, Roberto Freilone, Mattia Novo   +10 more
doaj   +1 more source

Outcomes after alemtuzumab-containing reduced-intensity allogeneic transplantation regimen for relapsed and refractory non-Hodgkin lymphoma

, 2004
We report the outcomes after reduced-intensity conditioning allogeneic stem cell transplantation (RIT) for non-Hodgkin lymphoma (NHL) in 88 patients (low-grade NHL [LG-NHL], n = 41; high-grade NHL [HG-NHL], n = 37; mantle cell lymphoma [MCL], n = 10 ...
Mahendra, P, Smith, GM, Cook, G., Hatton, C., Tighe, J., Morris, E., Goldstone, A, Peggs, K., Cook, G, Mahendra, Premini, Hunter, A., Mackinnon, S, Milligan, D., Smith, G.M., Goldstone, A., Chopra, R, Hunter, A, Linch, D., Parker, A, Linch, D, Morris, E, Hunter, A.H., Milligan, D, Thomson, K, Parker, A., Peggs, K, Chopra, R., Thomson, K., Craddock, C., Hatton, C, Mackinnon, S., Milligan, Donald, Mahendra, P., Schey, S., Craddock, Charles; id_orcid, Craddock, C, Schey, S, Tighe, J   +37 more
core   +1 more source

Allograft for Myeloma: Examining Pieces of the Jigsaw Puzzle

Frontiers in Oncology, 2017
Multiple myeloma (MM) cure remains elusive despite the availability of newer anti-myeloma agents. Patients with high-risk disease often suffer from early relapse and short survival.
Ehsan Malek, Najla El-Jurdi, Nicolaus Kröger, Marcos de Lima   +3 more
doaj   +1 more source

Optimization of the indications for allogeneic stem cell transplantation in Acute Myeloid Leukemia based on interactive diagnostic strategies

, 2011
The indications for allogeneic stem cell transplantation (SCT) in Acute Myeloid Leukemia (AML) represent a real challenge due to the clinical and genetic heterogeneity of the disorder.
Hartwig, Maite, Zander, Axel R., Haferlach, Torsten, Fehse, Boris, Bacher, Ulrike, Kröger, Nicolaus   +5 more
core   +1 more source

Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation:a Global Observational Study [PDF]

, 2013
Fifty-five years after publication of the first hematopoietic stem cell transplantation this technique has become an accepted treatment option for defined hematologic and non-hematologic disorders.
Madrigal, Alejandro, Horowitz, Mary, Passweg, Jakob, Bouzas, Luis Fernando, Szer, Jeff, Niederwieser, Dietger, Gratwohl, Alois, Aljurf, Mahmoud, Iida, Minako, Kodera, Yoshihisa, Worldwide Network Blood Marrow Tra, Pasquini, Marcelo C., Marrow Transplantation,, Lipton, Jeff, Worldwide Network of Blood,, Gratwohl, Michael, Baldomero, Helen, Frauendorfer, Karl   +17 more
core   +1 more source