Results 31 to 40 of about 307,259 (361)

Physiological problems in patients undergoing autologous and allogeneic hematopoietic stem cell transplantation

Asia-Pacific Journal of Oncology Nursing, 2014
Objective: Stem cell transplantation is usually performed in an effort to extend the patient′s life span and to improve their quality of life. This study was conducted to determine the postoperative physiological effects experienced by patients who had ...
Sevgisun Kapucu, Yasemin Karacan
doaj   +1 more source

Patient reported outcomes in view of symptom experience of late effects and self-management of adult long-term survivors after allogeneic haematopoietic stem cell transplantation - a mixed methods study [PDF]

, 2014
Even years after allogeneic stem cell transplantation, recipients face a continuing risk of developing serious late effects. Previous studies have focused on the pathophysiological understanding of late effects, as well as on treatment and disease ...
Kirsch, Monika
core   +1 more source

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

Nature Biotechnology, 2019
Autologous induced pluripotent stem cells (iPSCs) constitute an unlimited cell source for patient-specific cell-based organ repair strategies. However, their generation and subsequent differentiation into specific cells or tissues entail cell line ...
T. Deuse, Xiaomeng Hu, A. Gravina, D. Wang, G. Tediashvili, C. De, W. Thayer, A. Wahl, J. Garcia, H. Reichenspurner, Mark M. Davis, L. Lanier, S. Schrepfer   +12 more
semanticscholar   +1 more source

Allogeneic transplantation for Hodgkin’s lymphoma [PDF]

British Journal of Haematology, 2010
SummaryHodgkin’s lymphoma (HL) can be cured in most of the patients, but in case of refractory disease or relapse after autologous stem cell transplantation (SCT) the prognosis becomes very poor. In these patients a consensus about the standard approach has not been achieved so far and only allogeneic SCT has shown a long‐term disease control.
P. Corradini, B. Sarina, L. Farina
openaire   +3 more sources

Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?

Frontiers in Immunology, 2017
Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppressive/anti-inflammatory ...
Paul Lohan, Oliver Treacy, Oliver Treacy, Matthew D. Griffin, Matthew D. Griffin, Thomas Ritter, Thomas Ritter, Aideen E. Ryan, Aideen E. Ryan   +8 more
doaj   +1 more source

Presence of innate lymphoid cells in allogeneic hematopoietic grafts correlates with reduced graft-versus-host disease. [PDF]

, 2022
BACKGROUND Allogeneic hematopoietic cell transplantation (HCT) can be devastating when graft-versus-host disease (GvHD) develops. GvHD is characterized by mucosal inflammation due to breaching of epithelial barriers.
Weterings, Naomi, Hazenberg, Mette D., Verheij, Myrddin W, van Hoeven, Vera, Kroeze, Anna, Voermans, Carlijn, Zeerleder, Sacha S, Turksma, Annelies W., van Gassen, Sofie, Hazenberg, Mette D, Turksma, Annelies W, Verheij, Myrddin W., Blom, Bianca, Zeerleder, Sacha S.   +13 more
core   +1 more source

Clonal karyotype evolution involving ring chromosome 1 with myelodysplastic syndrome subtype RAEB-t progressing into acute leukemia [PDF]

, 2006
s Karyotypic evolution is a well-known phenomenon in patients with malignant hernatological disorders during disease progression. We describe a 50-year-old male patient who had originally presented with pancytopenia in October 1992.
Wunderlich, Bettina, Kolb, Hans Jochem, Schmetzer, Helga Maria, Schmid, C., Schmetzer, H.M., Kolb, Hans Jochen, Poleck-Dehlin, Brigitte, Poleck-Dehlin, B., Mittermueller, Johann, Schmid, Christoph, Wunderlich, B., Ledderose, G., Mittermüller, Johann, Schmetzer, Helga, Ledderose, Georg, Duell, T., Mittermüller, J., Kolb, H.-J., Duell, Thomas   +18 more
core   +1 more source

Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial

Nature Medicine
There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord blood-derived natural killer (NK) cells expressing anti-CD19 chimeric antigen ...
David Marin, Ye Li, R. Başar, H. Rafei, May Daher, J. Dou, Vakul Mohanty, Merve Dede, Y. Nieto, N. Uprety, S. Acharya, E. Liu, Jeffrey Wilson, P. Banerjee, H. Macapinlac, C. Ganesh, P. Thall, R. Bassett, Mariam Ammari, Sheetal S Rao, K. Cao, M. Shanley, Mecit Kaplan, C. Hosing, P. Kebriaei, L. Nastoupil, C. Flowers, S. M. Moseley, Paul Lin, Sonny Ang, U. Popat, M. Qazilbash, R. Champlin, Ken Chen, E. Shpall, K. Rezvani   +35 more
semanticscholar   +1 more source

The 2023 EBMT report on hematopoietic cell transplantation and cellular therapies. Increased use of allogeneic HCT for myeloid malignancies and of CAR-T at the expense of autologous HCT

Bone Marrow Transplantation
In 2023, 47,731 HCT (20,485 (42.9%) allogeneic and 27,246 (57.1%) autologous) in 43,902 patients were reported by 696 European centers. 6042 patients received advanced cellular therapies, 4888 of which were CAR-T.
J. Passweg, H. Baldomero, M. Atlija, Iliana Kleovoulou, Aleksandra Witaszek, T. Alexander, E. Angelucci, D. Averbuch, A. Bazarbachi, F. Ciceri, R. Greco, M. Hazenberg, K. Kałwak, D. Mclornan, B. Neven, Z. Perić, A. Risitano, A. Ruggeri, I. Sánchez-Ortega, J. Snowden, A. Sureda   +20 more
semanticscholar   +1 more source

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

Nature Biotechnology, 2017
Polymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection of pluripotent stem cell (PSC)-derived products in allogeneic recipients.
Germán G. Gornalusse, R. Hirata, S. Funk, Laura Riolobos, V. Lopes, Gabriel Manske, D. Prunkard, A. Colunga, L. Hanafi, D. Clegg, C. Turtle, D. Russell   +11 more
semanticscholar   +1 more source