Results 21 to 30 of about 307,259 (361)

A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation

Haematologica, 2016
Improvement of graft-versus-host disease prophylaxis remains an important goal in allogeneic hematopoietic stem cell transplantation. Based on reports of possibly preferential properties of sirolimus, we compared the standard regimen of cyclosporine and ...
Johan Törlén, Olle Ringdén, Karin Garming-Legert, Per Ljungman, Jacek Winiarski, Kari Remes, Maija Itälä-Remes, Mats Remberger, Jonas Mattsson   +8 more
doaj   +1 more source

Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry

Frontiers in Immunology, 2023
IntroductionCOVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients.MethodsThis study reports on 986 patients reported to the EBMT registry during the first 29 months of the ...
Per Ljungman, Per Ljungman, Gloria Tridello, Jose Luis Piñana, Jose Luis Piñana, Fabio Ciceri, Henrik Sengeloev, Alexander Kulagin, Stephan Mielke, Stephan Mielke, Zeynep Arzu Yegin, Matthew Collin, Sigrun Einardottir, Sigrun Einardottir, Sophie Ducastelle Lepretre, Johan Maertens, Antonio Campos, Elisabetta Metafuni, Herbert Pichler, Frantisek Folber, Frantisek Folber, Carlos Solano, Emma Nicholson, Meltem Kurt Yüksel, Kristina Carlson, Beatriz Aguado, Caroline Besley, Jenny Byrne, Immaculada Heras, Fiona Dignan, Nicolaus Kröger, Christine Robin, Anjum Khan, Stig Lenhoff, Anna Grassi, Veronika Dobsinska, Nuno Miranda, Maria-Jose Jimenez, Ipek Yonal-Hindilerden, Keith Wilson, Dina Averbuch, Simone Cesaro, Alienor Xhaard, Nina Knelange, Jan Styczynski, Malgorzata Mikulska, Rafael de la Camara   +46 more
doaj   +1 more source

IFNγ, and to a Lesser Extent TNFα, Provokes a Sustained Endothelial Costimulatory Phenotype

Frontiers in Immunology, 2021
BackgroundVascular endothelial cells (EC) are critical for regulation of local immune responses, through coordination of leukocyte recruitment from the blood and egress into the tissue.
Nicole M. Valenzuela
doaj   +1 more source

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Kolb, Hans-Jochem, Roskrow, Marie, Guenther, Wolfgang, Schmid, Christoph, Ledderose, Georg, Weber, Martin, Chen, Xiao, Schleuning, Michael, Woiciechowski, Anja   +8 more
core   +1 more source

Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts

CNS Oncology, 2018
Aim: ERC1671 is an allogeneic/autologous therapeutic glioblastoma (GBM) vaccine – composed of whole, inactivated tumor cells mixed with tumor cell lysates derived from the patient and three GBM donors.
Daniela A Bota, Jinah Chung, Manisha Dandekar, Jose A Carrillo, Xiao-Tang Kong, Beverly D Fu, Frank PK Hsu, Axel H Schönthal, Florence M Hofman, Thomas C Chen, Raphael Zidovetzki, Chrystel Pretto, Ankie Strik, Virgil EJC Schijns, Apostolos Stathopoulos   +14 more
doaj   +1 more source

Pharmacologic Therapies to Prevent Relapse of Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation

Frontiers in Oncology, 2020
Relapse is the main cause of mortality in patients with acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Ahmad I. Antar, Ahmad I. Antar, Zaher K. Otrock, Iman Abou Dalle, Jean El-Cheikh, Ali Bazarbachi   +5 more
doaj   +1 more source

Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes

Frontiers in Veterinary Science, 2021
Despite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient.
J. Lacy Kamm, Christopher B. Riley, Natalie Parlane, Erica K Gee, C. Wayne McIlwraith   +4 more
doaj   +1 more source

Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer

Cellular & Molecular Immunology, 2020
Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for clinical application. To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the
Yan Xu, Zheng Xiang, Mohammed Alnaggar, Léonce Kouakanou, Jiawei Li, Junyi He, Jiashuang Yang, Y. Hu, Yan Chen, Li Lin, Jianlei Hao, Jingxia Li, Jibing Chen, Man Li, Qingling Wu, C. Peters, Qinghua Zhou, Jianshuang Li, Yingqing Liang, Xiaohua Wang, B. Han, M. Ma, D. Kabelitz, Kecheng Xu, W. Tu, Yangzhe Wu, Z. Yin   +26 more
semanticscholar   +1 more source

Survival, non-relapse mortality, and relapse-related mortality after allogeneic hematopoietic cell transplantation: Comparing 2003-2007 vs. 2013-2017 cohorts

Annals of Internal Medicine, 2020
Background: Allogeneic hematopoietic cell transplantation is indicated for refractory hematologic malignancy and some non-malignant disorders. Survival is limited by recurrent malignancy and organ toxicity.
George B. McDonald, B. Sandmaier, M. Mielcarek, M. Sorror, S. Pergam, G. Cheng, S. Hingorani, M. Boeckh, M. Flowers, Stephanie J. Lee, F. Appelbaum, R. Storb, P. Martin, H. Deeg, G. Schoch, T. Gooley   +15 more
semanticscholar   +1 more source

The pattern of blood loss in adolescent idiopathic scoliosis [PDF]

, 2014
Background context Previous studies have shown that modern intraoperative blood-saving techniques dramatically reduce the allogeneic transfusion requirements in surgery for adolescent idiopathic scoliosis (AIS).
Patel, Davandra, Verma, Rajat, Stephenson, John, Van Popta, Dmitri   +3 more
core   +1 more source