Results 101 to 110 of about 58,791 (313)

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

High IL1R1 expression predicts poor survival and benefit from stem cell transplant in intermediate-risk acute myeloid leukemia from the Leucegene cohort

Biomarker Research
Background There is an unmet clinical need to identify patients with acute myeloid leukemia and intermediate-risk cytogenetics who benefit from allogeneic hematopoietic stem cell transplantation in first remission, especially among those without FLT3-ITD
Guillaume Richard-Carpentier, François Béliveau, Sandrine Lacoste, Banafsheh Khakipoor, Véronique Lisi, Michael Vladovsky, Miriam Marquis, Jean-François Spinella, Patrick Gendron, Sébastien Lemieux, Vincent-Philippe Lavallée, Guy Sauvageau, Josée Hébert   +12 more
doaj   +1 more source

Allogeneic hematopoietic stem cell transplantation for myelofibrosis

Haematologica, 2008
Primary myelofibrosis (PMF) or myelofibrosis secondary to polycythemia vera (PV-MF) or essential thrombocythemia (ET-MF) can be cured only by means of allogeneic hematopoietic stem cell transplantation (HSCT).[1][1] However, the age of the patient, the number of circulating blasts ...
openaire   +3 more sources

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

American Journal of Hematology, EarlyView.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong, Tamara Wais, Cecilia Varga, Christina Schueller, Sarada Achyutuni, Robert Kralovics   +5 more
wiley   +1 more source

Relationship between minimal residual disease measured by multiparametric flow cytometry prior to allogeneic hematopoietic stem cell transplantation and outcome in children with acute lymphoblastic leukemia

Haematologica, 2010
Background The presence of minimal residual disease detected by polymerase chain reaction techniques prior to allogeneic hematopoietic stem cell transplantation has proven to be an independent prognostic factor for poor outcome in children with acute ...
Izaskun Elorza, Carlos Palacio, Jose Luis Dapena, Laura Gallur, José Sánchez de Toledo, Cristina Díaz de Heredia   +5 more
doaj   +1 more source

Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel [PDF]

, 2017
Théo de Witte, David Bowen, Marie Robin, Luca Malcovati, Dietger Niederwieser, Ibrahim Yakoub‐Agha, Ghulam J. Mufti, Pierre Fenaux, Guillermo Sanz, Rodrigo Martino, Emilio Paolo Alessandrino, Francesco Onida, Argiris Symeonidis, Jakob Passweg, Guido Kobbe, Arnold Ganser, Uwe Platzbecker, Jürgen Finke, Michel van Gelder, Arjan A. van de Loosdrecht, Per Ljungman, Reinhard Stauder, Liisa Volin, H. Joachim Deeg, Corey Cutler, Wael Saber, Richard E. Champlin, Sergio Giralt, Claudio Anasetti, Nicolaus Kröger   +29 more
openalex   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Allogeneic hematopoietic stem cell transplantation after rituximab-containing myeloablative preparative regimen for acute lymphoblastic leukemia [PDF]

, 2006
Partow Kebriaei, Rima M. Saliba, Carrie Ma, Cindy Ippoliti, Daniel R. Couriel, Marcos de Lima, Sergio Giralt, Muzaffar H. Qazilbash, James Gajewski, Chul S. Ha, Richard E. Champlin, Issa F. Khouri   +11 more
openalex   +1 more source

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, EarlyView.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

Hematopoietic Stem Cell Transplantation in PML-RARa Positive Acute Promyelocytic Leukemia [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2011
Introduction: Acute promyelocytic leukemia treatment revolutionized by new tretaMNETS. Currently number of patinets who undergoe hematopoietic stem cell transplantation decrased so experience with this modality is limited.
Shahrbanoo Rostami, Roshanak Derakhshandeh, Maryam Behfar, Babak Bahar, Asadolah Mousavi, Amir Ali Hamidieh, Hoda Jorjani, Massoud Iravani, Arash Jalali, Mohamad Jahani, Kamran Alimoghaddam, Ardeshir Ghavamzadeh   +11 more
doaj   +2 more sources