Results 121 to 130 of about 256,813 (405)

The role of the thymus in allogeneic hematopoietic stem cell transplantation

Swiss Medical Weekly, 2010
Allogeneic haematopoietic stem cell transplantation (HSCT) is used to treat an increasing number of congenital and acquired disorders of the haematopoietic system. Even though cytoreductive conditioning regimens vary in intensity, all clinically used protocols invariably cause side effects that compromise transiently or long-term the response of the ...
Krenger, Werner, Holländer, Georg A.
openaire   +4 more sources

Dynamics of a Mathematical Hematopoietic Stem-Cell Population Model [PDF]

Journal on Applied Dynamical Systems, 18 (2019), 808-852, 2017
We explore the bifurcations and dynamics of a scalar differential equation with a single constant delay which models the population of human hematopoietic stem cells in the bone marrow. One parameter continuation reveals that with a delay of just a few days, stable periodic dynamics can be generated of all periods from about one week up to one decade ...
arxiv   +1 more source

Potential Risks to Stable Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Children With Cerebral X-linked Adrenoleukodystrophy

JAMA Network Open, 2018
Key Points Question What are the risks to stable neurocognitive outcome after allogeneic hematopoietic stem cell transplantation for childhood cerebral X-linked adrenoleukodystrophy? Findings This single-center case series involving 36 boys with cerebral
J. Kühl, J. Kupper, Hermann Baqué, W. Ebell, J. Gärtner, C. Korenke, B. Spors, Ingo G. Steffen, G. Strauss, S. Voigt, B. Weschke, A. Weddige, W. Köhler, R. Steinfeld   +13 more
semanticscholar   +1 more source

Donor hematopoietic progenitor cells in nonmyeloablated rat recipients of allogeneic bone marrow and liver grafts [PDF]

, 1999
Background. Although the persistence of multilineage microchimerism in recipients of long-surviving organ transplants implies engraftment of migratory pluripotent donor stem cells, the ultimate localization in the recipient of these cells has not been ...
Demetris, AJ, Lu, L, Murase, N, Sakamoto, T, Starzl, TE, Ye, Q   +5 more
core   +1 more source

Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Juvenile Metachromatic Leukodystrophy Compared With Nontransplanted Control Patients.

JAMA Neurology, 2016
IMPORTANCE Allogeneic hematopoietic stem cell transplantation (HSCT) has been the only treatment option clinically available during the last 20 years for juvenile metachromatic leukodystrophy (MLD), reported with variable outcome and without comparison ...
S. Groeschel, J. Kühl, A. Bley, C. Kehrer, B. Weschke, M. Döring, J. Böhringer, J. Schrum, R. Santer, A. Kohlschütter, I. Krägeloh-Mann, I. Müller   +11 more
semanticscholar   +1 more source

TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah, Daniel A. Arber, Devendra K. Hiwase   +2 more
wiley   +1 more source

Experience of BK Virus in Allogenic and Autologous Bone Marrow Transplantation:

Mediterranean Journal of Hematology and Infectious Diseases, 2014
The BK virus is a member of the polyomavirus family. When the immune system is compromised, as in patients undergoing chemotherapy after hematopoietic stem cell and solid organ transplantation, the virus is reactivated leading to haemorrhagic cystitis ...
Ilhami BERBER, Mehmet Ali ERKURT, Emin KAYA, Irfan KUKU, Mustafa KOROGLU, Ilknur NIZAM   +5 more
doaj  

BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT. [PDF]

, 2014
The genetic background of donor and recipient is an important factor determining the outcome of allogeneic hematopoietic SCT (allo-HSCT). We applied whole-genome analysis to investigate genetic variants - other than HLA class I and II - associated with ...
Andreani M, Angius A, Bacchetta R., Bulfone A, Ciceri F, Fleischhauer K, Floris M, Gregori S, LA NASA, GIORGIO, Lucarelli G, Marktel S, Piras I. S, Roncarolo M. G, Testi M   +13 more
core   +1 more source

Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype.

Journal of the American Medical Association (JAMA), 2014
IMPORTANCE Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults.
M. Hsieh, C. Fitzhugh, R. Weitzel, Mary E. Link, W. Coles, Xiongce Zhao, G. Rodgers, J. Powell, J. Tisdale, Mary J. Hsieh, S. Kimmel   +10 more
semanticscholar   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source