Results 181 to 190 of about 415,260 (411)

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source

Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.

Journal of Infectious Diseases, 2013
BACKGROUND The long-term impact of allogeneic hematopoietic stem cell transplantation (HSCT) on human immunodeficiency virus type 1 (HIV-1) reservoirs in patients receiving combination antiretroviral therapy (cART) is largely unknown.
T. Henrich, Zixin Hu, Jonathan Z. Li, G. Sciaranghella, M. Busch, S. Keating, S. Gallien, N. Lin, Francoise F. Giguel, Laura Lavoie, V. Ho, P. Armand, R. Soiffer, M. Sagar, A. LaCasce, D. Kuritzkes   +15 more
semanticscholar   +1 more source

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

Advanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao, Siwen Chen, Hua Chao, Zihao Li, Hao Yang, Dongying Chen, Sifang Li, Shuai Zhang, Jingyu Zhang, Jianru Wang, Zemin Li, Xiang Li, Zhongping Zhan, Tangming Guan, Yiwen Zhang, Wende Li, Hui Liu   +16 more
wiley   +1 more source

Isologous Diversification: A Theory of Cell Differentiation [PDF]

arXiv, 1996
Isologous diversification theory for cell differentiation is proposed, based on simulations of interacting cells with biochemical networks and cell division process following consumption of some chemicals. According to the simulations of the interaction-based dynamical systems model, the following scenario of the cell differentiation is proposed.
arxiv  

Peripheral Blood Stem Cells: A Novel Source for Allogeneic Transplantation [PDF]

, 1997
Martin Körbling
openalex   +1 more source

Durability of responses following donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia [PDF]

, 2000
Francesco Dazzi, Richard Szydlo, Nicholas C.P. Cross, Charles Craddock, Jaspal Kaeda, Ed Kanfer, Kate Cwynarski, Eduardo Olavarría, Agnes S. M. Yong, Jane F. Apperley, John M. Goldman   +10 more
openalex   +2 more sources

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

Dendritic cells generated from induced pluripotent stem cells and by direct reprogramming of somatic cells

European Journal of Immunology, Volume 52, Issue 12, Page 1880-1888, December 2022., 2022
Somatic cells (fibroblasts, dendritic cells, T cells) are reprogrammed into induced pluripotent stem cells (iPS cells) with specific transcription factors. iPS cells are then differentiated into iPS cell‐derived DC (ipDC) with DC inducing cytokines. Fibroblasts are directly reprogrammed into induced DC (iDC) by DC specific transcription factors (direct
Niclas Flosdorf, Martin Zenke
wiley   +1 more source

Is Stem Cell a Curer or an Obstruction?

MCBS (Molecular and Cellular Biomedical Sciences), 2017
Stem cell research and therapy are progressing these days dramatically. Stem cell therapy holds enormous treatment potential for many diseases which currently have no or limited therapeutic options.
Siska Darmayanti, Rina Triana, Angliana Chouw, Nurrani Mustika Dewi   +3 more
doaj   +1 more source

Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation [PDF]

, 1996
Jack W. Singer, R Clift, Patrick Martin, FR Appelbaum, Taner Demirer, Ted Gooley, K Lilleby, S Rowley, Jan‐Stephan Sanders, R Storb, CD Buckner   +10 more
openalex   +1 more source