Results 181 to 190 of about 166,368 (358)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

American Journal of Hematology, EarlyView.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong, Tamara Wais, Cecilia Varga, Christina Schueller, Sarada Achyutuni, Robert Kralovics   +5 more
wiley   +1 more source

"The antibiotic paradox" in allogeneic stem cell transplantation. [PDF]

Bone Marrow Transplant
Weber D, Meedt E, Ghimire S, Hiergeist A, Kern MAG, Höpting M, Thiele Orberg E, Shaikh H, Beilhack A, Wolff D, Edinger M, Herr W, Gessner A, Poeck H, Holler E.   +14 more
europepmc   +1 more source

Iron Overload in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

, 2014
Alessandro Busca, Chiara Maria Dellacasa, Clara Pecoraro   +2 more
openalex   +2 more sources

Recent advances in animal models for pathological scar research: A comprehensive review of experimental approaches and translational relevance

Animal Models and Experimental Medicine, EarlyView.
Animal models remain indispensable in the study of pathological scars, each offering unique advantages and constraints. Their integration with in vitro and ex vivo systems is key to developing personalized, clinically translatable antifibrotic therapies. Abstract Pathological scarring, manifested in the form of hypertrophic scars (HTS) and keloid scars
Diana‐Larisa Ancuța, Mariana Văduva, Cristin Coman, Iuliana Caraș   +3 more
wiley   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Utility and Safety of Romiplostim in Pediatric Allogeneic Stem Cell Transplantation. [PDF]

Pediatr Transplant
Senthil S, Moothedath A, Potter JE, Wilkinson HM, Whiteside E, Nataraj R, Mustafa O, Horgan C, Bonney D, Brett S, Wynn R.   +10 more
europepmc   +1 more source

Remission of a long-lasting sarcoidosis after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia [PDF]

, 2016
Emmanuelle Ginoux, D. Kottler, Bruno Anglaret, B. Balme, Claude‐Eric Bulabois, F. Skowron   +5 more
openalex   +1 more source

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, EarlyView.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

Durable Response in Histiocytic Sarcoma After Allogeneic Stem Cell Transplantation: A Case Report. [PDF]

Hematol Rep
Oliva S, Gill J, Boccellato E, Mortara U, Molinaro L, Godio L, Sieni E, Buccoliero AM, Dogliotti I, Busca A, Califaretti E, Benedetto B, Giaccone L.   +12 more
europepmc   +1 more source