Results 161 to 170 of about 45,108 (330)

Mechanistic Insights Into How Rewiring and Bifurcation Angle Affect DK‐Crush Stent Deployment

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Double kissing crush (DKC) is a preferred two‐stent technique for complex coronary bifurcation lesions. Proximal cell rewiring is routinely recommended to reduce technical failure, and DKC is considered effective across various bifurcation angles. However, it remains unclear whether this standard approach is optimal for all patients.
Andrea Colombo, Dario Carbonaro, Mingzi Zhang, Claudio Chiastra, Mark Webster, Nigel Jepson, Susann Beier   +6 more
wiley   +1 more source

TEŽINSKO–DUŽINSKI ODNOS 57 RIBLJIH VRSTA U RIJEKAMA JUGOISTOČNOG DIJELA OBALE BJELOKOSTI [PDF]

, 2007
Weight–length relationships (WLR) of 57 fish species belonging to 22 families from the coastal rivers of the south–eastern of Ivory Coast were studied. Samples were collected with two fleets of monofilament gill nets.
A. Ouattara, G. Gourčne, K. F. Konan, M. Ouattara   +3 more
core   +2 more sources

Dosing Biologic Drugs for Patients with Obesity: One Size Does NOT Fit All

Arthritis &Rheumatology, Accepted Article.
Stephen J. Balevic, Daniel Gonzalez, Bernd Meibohm   +2 more
wiley   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Ontogenetic allometry in the foot size of Oligoryzomys flavescens (Waterhouse, 1837) (Rodentia, Sigmodontinae)

Brazilian Journal of Biology
Ontogenetic allometry is the study of how the size or shape of certain structures changes over the course of an animal’s development. In this study, using Huxley's formula of allometric growth (1932), we assessed the changes in the rate of growth of the ...
R. Maestri, R. Fornel, TRO. Freitas, JR. Marinho   +3 more
doaj   +1 more source

Sexual dimorphism and inter-individual variation in the rove beetle, Creophilus maxillosus L. (Col: Staphylinidae) [PDF]

Arthropods, 2017
Sexual selection is expected to drive phenotypic differences between conspecific male and females, a widespread phenomenon known as sexual dimorphism. At the same time, individuals may exhibit some degree of intra-sexual variation. We examined the sexual
Mohammad Shahbaz, Gadir Nouri-Ganbalani
doaj  

Optimizing Body Size‐Based Dosing Approaches for Antibody–Drug Conjugates

Clinical Pharmacology &Therapeutics, EarlyView.
Optimized dosing precision of antibody–drug conjugates (ADCs) remains challenging due to narrow therapeutic indices, efficacious doses near the maximum tolerated dose, and substantial interindividual variability in exposure. Body size‐based dosing can reduce exposure variability when the allometric scaling exponent for clearance α = 1 but may over‐ or ...
Andrew B. SyBing, Diane D. Wang
wiley   +1 more source

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

Clinical Pharmacology &Therapeutics, EarlyView.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu, Farina Hellmann, Xiaowei Zang, Nele Plock, Keyur Parmar, Radha A. Railkar, S. Y. Amy Cheung, Brian M. Maas, Ferdous Gheyas   +8 more
wiley   +1 more source

Population Pharmacokinetic and Exposure‐Efficacy Analysis of Baloxavir Marboxil for Influenza Treatment and Post‐Exposure Prophylaxis in Children

Clinical Pharmacology &Therapeutics, EarlyView.
Baloxavir acid (baloxavir), the active metabolite of the prodrug baloxavir marboxil, is a selective inhibitor of the influenza virus cap‐dependent endonuclease. The population pharmacokinetic (popPK) profile of baloxavir in adults/adolescents has been described previously.
Sylvie Retout, Stefan De Buck, Jacques Gaudreault, Sébastien Jolivet, Vincent Duval, Valérie Cosson, Marie‐Laure Delporte   +6 more
wiley   +1 more source

Developing a macroecology for human‐altered ecosystems

Ecography, EarlyView.
Although anthropogenically‐induced ecological disruptions are fundamentally important in defining ecosystem properties, they are largely overlooked by macroecological theory. Anthropogenic disruptions and their effects are generally not comparable to one another, nor to disturbances that are part of natural disturbance regimes.
Erica A. Newman, Mark Q. Wilber, Alexandre Génin, Oriana E. Chafe, Henry F. Houskeeper, Steven Lee, Eric L. Berlow, John Harte   +7 more
wiley   +1 more source