Results 261 to 270 of about 12,622 (280)

Alcohol, allopregnanolone and aggression in mice

Psychopharmacology, 2000
Aggressive behavior of certain individual animals can be greatly increased when under the influence of low doses of alcohol. One of alcohol's neurochemical actions that may be relevant to alcohol-heightened aggression (AHA) is its positive modulation of the GABA(A) receptor complex.The objective of this study was to investigate whether alcohol ...
E W, Fish, S, Faccidomo, J F, DeBold, K A, Miczek   +3 more
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Serum Allopregnanolone in Women With Postpartum “Blues”

Obstetrics & Gynecology, 2001
To relate serum allopregnanolone and progesterone levels postpartum to maternity "blues."Forty primiparous, healthy, married women (24-39 years of age; at least 13 years of education) who delivered healthy neonates in the Department of Obstetrics at the University of Pavia entered the present study. Blood samples were drawn at 8:30 AM on postpartum day
NAPPI, R. E., PETRAGLIA, F., LUISI, S., POLATTI, F., FARINA, C., GENAZZANI, A. R.   +5 more
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Physiological markers of rapid antidepressant effects of allopregnanolone

Journal of Neuroendocrinology, 2021
Abstract The rise of ketamine and brexanolone as rapid antidepressant treatments raises the question of common mechanisms. Both drugs act without the long onset time of traditional antidepressants such as selective serotonin reuptake inhibitors.
Peter M. Lambert, Xinguo Lu, Charles F. Zorumski, Steven Mennerick   +3 more
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Flumazenil blocks the anxiolytic action of allopregnanolone

European Journal of Pharmacology, 1995
In the burying behaviour test allopregnanolone (0.5 mg/rat) reduced the cumulative time of burying, interpreted as a reduction in anxiety. The selective benzodiazepine antagonist, flumazenil (5 and 10 mg/kg), did not affect the burying behaviour when administered alone but effectively prevented the reduction produced by allopregnanolone.
A, Fernández-Guasti, O, Picazo
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Anticonvulsant action of allopregnanolone in immature rats

Epilepsy Research, 2006
Anticonvulsant activity of allopregnanolone, a neurosteroid allosterically modulating GABA(A) receptor was tested in a model of motor seizures elicited by pentetrazol in immature rats. Rats 7, 12, 18, 25 or 90 days old were pretreated with allopregnanolone in doses from 5 to 40 mg/kg i.p.
P, Mares, A, Mikulecká, R, Haugvicová, A, Kasal   +3 more
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Nanomolar allopregnanolone potentiates rat cerebellar GABAA receptors

Neuroscience Letters, 2005
The ionophore function of gamma-aminobutyric acid A (GABA(A)) receptors was studied by whole-cell patch clamp electrophysiology in primary cultures of rat cerebellar cortex. Chloride currents elicited by 1 microM GABA were potentiated by allopregnanolone with a plateau of high affinity (EC(50) = 14 nM) and a peak of potentiation around 1 microM ...
László, Fodor, Tímea, Bíró, Gábor, Maksay   +2 more
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Allopregnanolone impairs episodic memory in healthy women

Psychopharmacology, 2008
Allopregnanolone is an endogenous neuroactive steroid that, through its binding to the gamma-aminobutyric acid (GABA) A receptor, has GABA-active properties. Animal studies indicate that allopregnanolone administration results in diminished learning and memory impairment.
Kristiina, Kask, Torbjörn, Bäckström, Lars-Göran, Nilsson, Inger, Sundström-Poromaa   +3 more
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Allopregnanolone Affects Sleep in a Benzodiazepine-Like Fashion

The Journal of Pharmacology and Experimental Therapeutics, 1997
Recent research in rats and humans has shown that exogenous progesterone evokes a sleep profile similar to that induced by agonistic modulators of gamma-aminobutyric acid(A) receptors, such as benzodiazepines. This finding suggests the involvement of the neuroactive metabolite of progesterone, allopregnanolone.
Lancel M., Faulhaber J., Schiffelholz T., ROMEO, ELENA, Di Michele F., Holsboer F., Rupprecht R.   +6 more
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GABAA receptor changes in acute allopregnanolone tolerance

European Journal of Pharmacology, 2006
To study acute tolerance, rats were anesthetized with interrupted i.v. allopregnanolone infusions where the "silent second" in the electroencephalogram (EEG) was the target. Animals were killed either directly at the first silent second or at the silent second level after 30 or 90 min of anaesthesia.
Vita, Birzniece, Sahruh, Türkmen, Charlotte, Lindblad, Di, Zhu, Inga-Maj, Johansson, Torbjörn, Bäckström, Göran, Wahlström   +6 more
openaire   +2 more sources

Olanzapine increases allopregnanolone in the rat cerebral cortex

Biological Psychiatry, 2000
The neurosteroid allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) has anxiolytic and anticonvulsant properties, potentiating GABA(A) receptor chloride channel function with 20-fold higher potency than benzodiazepines. Behavioral studies demonstrate that olanzapine has anxiolyticlike properties in animals, but the mechanism responsible for these ...
C E, Marx, G E, Duncan, J H, Gilmore, J A, Lieberman, A L, Morrow   +4 more
openaire   +2 more sources