Results 271 to 280 of about 12,622 (280)

PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma.

Psychoneuroendocrinology, 2018
There is a need to identify new and more effective treatments for posttraumatic stress disorder (PTSD). Allopregnanolone and its stereoisomer pregnanolone (together termed ALLO) are metabolites of progesterone that positively and allosterically modulate ...
S. Pineles, S. Pineles, Yael I. Nillni, G. Pinna, J. Irvine, Andrea K. Webb, K. A. Hall, R. Hauger, Mark W. Miller, P. Resick, S. Orr, A. Rasmusson   +11 more
semanticscholar   +1 more source

Progesterone metabolite allopregnanolone in women with premenstrual syndrome

Obstetrics & Gynecology, 1997
To evaluate the anxiolytic 3alpha-5alpha-reduced progesterone metabolite allopregnanolone in the luteal phase of the menstrual cycle in women with premenstrual syndrome (PMS) and controls.Thirty-five women with prospectively documented PMS and 36 controls were evaluated.
A J, Rapkin, M, Morgan, L, Goldman, D W, Brann, D, Simone, V B, Mahesh   +5 more
openaire   +2 more sources

Decreased serum allopregnanolone and progesterone levels in male patients with bipolar disorder and their effects on cognitive functions

European Archives of Psychiatry and Clinical Neuroscience, 2023
Mihrali Karademir, Elmas Beyazyüz, M. Beyazyüz, Ahsen Yılmaz, Y. Albayrak   +4 more
semanticscholar   +1 more source

The role of allopregnanolone in depression and anxiety

Progress in Neurobiology, 2014
Neuroactive steroids such as allopregnanolone do not only act as transcriptional factors in the regulation of gene expression after intracellular back-oxidation into the 5-α pregnane steroids but may also alter neuronal excitability through interactions with specific neurotransmitter receptors.
Cornelius, Schüle, Caroline, Nothdurfter, Rainer, Rupprecht   +2 more
openaire   +2 more sources

Reinforcing effects of the neurosteroid allopregnanolone in rats

Pharmacology Biochemistry and Behavior, 2002
The GABA(A) receptor positive modulator allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) is a potent neurosteroid with behavioral and biochemical characteristics similar to ethanol, barbiturates, and benzodiazepines. This suggests that neurosteroids may provide an alternative class of sedative/hypnotic, anticonvulsant, and anxiolytic ...
Rachna S, Sinnott, Gregory P, Mark, Deborah A, Finn   +2 more
openaire   +2 more sources

Suppressing aggressive behavior with analogs of allopregnanolone (epalon)

Steroids, 2001
3alpha-Hydroxy-20-oxo-5alpha-pregnan-21-yl hemisuccinate (8) was produced by partial acylation of 3alpha,21-dihydroxy-5alpha-pregnan-20-one (14). 3alpha-Fluoro-5alpha-pregnan-20-one (9) was prepared by treatment of 3beta-hydroxy-5alpha-pregnan-20-one (11) with DAST and by solvolysis of tosylate 12 with tetrabutylammonium fluoride.
B, Slavíková, A, Kasal, L, Uhlírová, M, Krsiak, H, Chodounská, L, Kohout   +5 more
openaire   +2 more sources

ALLOPREGNANOLONE

2023
openaire   +1 more source

Allopregnanolone

2016
Kazuyoshi Tsutsui, Shogo Haraguchi
openaire   +1 more source

ALCOHOL AND ALLOPREGNANOLONE LEVELS.

Alcoholism: Clinical & Experimental Research, 2004
S Nyberg, A Andersson, E Zingmark, G Wahlstr??m, T B??ckstr??m, I Sundstr??m-Poromaa   +5 more
openaire   +1 more source

Progesterone and Allopregnanolone Neuroprotective Effects in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis

Cellular and molecular neurobiology, 2021
A. D. De Nicola, M. Meyer, L. Garay, M. Kruse, M. Schumacher, R. Guennoun, M. G. Gonzalez Deniselle   +6 more
semanticscholar   +1 more source