Results 211 to 220 of about 151,004 (296)

Measuring Temporal Variations of Nucleotide Pools in Microbial Granular Biofilm

Helvetica Chimica Acta, EarlyView.
The developed metabolomics workflow enables quantification of energy nucleotides in complex microbial biofilms. The method provides a foundation for investigating rapid metabolic responses to dynamic environmental conditions. ABSTRACT Microbial communities often face environmental fluctuations that occur on timescales much shorter than their growth ...
Jitske M. van Ede, Timothy Páez‐Watson, Mark C. M. van Loosdrecht, Martin Pabst   +3 more
wiley   +1 more source

Epidermal growth factor receptor as a target enzyme in cancer therapy: Structural and functional insights from crystallography. [PDF]

Indian J Pharmacol
Magar VK, Khavane K, Wagh A, Shelke S, Padul R, Dudhane S.   +5 more
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Allostery is a widespread cause of loss-of-function variant pathogenicity. [PDF]

Nat Commun
Liao X, Lehner B.
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Pathological Allostery in ADAMTS13: Autoantibody-Induced Modulation and Its Role in Immune Thrombotic Thrombocytopenic Purpura (iTTP). [PDF]

Pharmaceuticals (Basel)
Gil M, Halkidis K.
europepmc   +1 more source

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

AMPK phosphorylation proceeds through hierarchical proteoform cascades revealed by integrated mass spectrometry. [PDF]

Sci Adv
Krichel B, Chan HJ, Bandura L, Gao Z, Wang MD, Rogers HT, Mcilwain SJ, Uetrecht C, Ge Y.   +8 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source