Results 231 to 240 of about 151,004 (296)

Conformational Dynamics of Viral Protease Precursors in Maturation, Inhibition, and Drug-Resistance Development. [PDF]

Viruses
Majerová T, Novotný P.
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Identification of a candidate PRODH allosteric inhibitor MBTP-15324: modulation of proline metabolite profiles and ECM-associated gene-expression changes in lung cancer cells. [PDF]

J Enzyme Inhib Med Chem
Zhou Y, Bai D, Li Z, Li C, Li C, Chen M, Guo C, Yan J, Han Y, Yang Q.   +9 more
europepmc   +1 more source

Novel Phosphodiesterase‑2 Inhibitors Discovered via Structure-Based Virtual Screening Targeting the Allosteric GAF‑B Domain. [PDF]

ACS Med Chem Lett
Adeniran C, Myratgeldiyev G, Zheng F, Zhan CG.   +3 more
europepmc   +1 more source

Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3. [PDF]

Protein Cell
Wu Y, Chen Q, Wang H, Liu K, Wei J, Wang M, Chen K, Zhu Y, Han S, Yi C, Ma L, Schnapp G, Pautsch A, Gnamm C, Grauert M, Schmidt E, Tan Q, Wu B, Zhao Q.   +18 more
europepmc   +1 more source

The allostery principle supports the symbolic character of signaling circuits: gene regulation provides a form of intelligence to living systems. [PDF]

Theory Biosci
Collado-Vides J.
europepmc   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV-1 Reverse Transcriptase. [PDF]

ChemMedChem
da Silva Moura JA, de Melo MVG, do Nascimento DRS, Bezerra TPW, Métifiot M, Recordon-Pinson P, da Rocha Pitta MG, da Rocha Pitta MG, Pereira MC, Andreola ML.   +9 more
europepmc   +1 more source

Identification and Characterization of a Phenyl(trifluoro-methyl)-pyrimidine Positive Allosteric Modulator of the Secretin Receptor. [PDF]

Membranes (Basel)
Harikumar KG, Dengler DG, Borrega Roman L, Ardecky R, Sergienko EA, Miller LJ.   +5 more
europepmc   +1 more source