Results 231 to 240 of about 137,279 (309)

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket. [PDF]

Protein Sci
Verma J, Vashisth H.
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis. [PDF]

Nat Commun
Hunt DM, Pisco JP, Rodgers A, de Chiara C, Zaveri A, Pacholarz KL, Evangelopoulos D, Garza-Garcia A, Ehrt S, Schnappinger D, Barran PE, Gutierrez MG, de Carvalho LPS.   +12 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes. [PDF]

Proc Natl Acad Sci U S A
Kearns FL, Bogetti AT, Calvó-Tusell C, Braza MKE, Casalino L, Gramm AJ, Braet S, Rosenfeld MA, Rajapaksha H, Barker B, Anand G, Chong LT, Ahn SH, Amaro RE.   +13 more
europepmc   +1 more source

Peptide‐Ligand Cooperative Interplay Drives Gold Nanoparticle Encapsulation by Protein Cages

Small, EarlyView.
Gold nanoparticle encapsulation within protein cages is governed by salt‐dependent binding energetics and cooperative peptide–ligand interactions. Ligands enhance electrostatic attraction while peptides extend recruitment and prevent kinetic trapping, enabling robust cargo loading. This molecular‐level insight links experiments and simulations, guiding
Wenhui Li, Niklas Mucke, Michael Rütten, Tommaso L. Schweers, Tobias Beck, Vikram Jadhao   +5 more
wiley   +1 more source

Free fatty acid receptor 2 allosterism is defined by cellular context. [PDF]

Cell Commun Signal
Lind S, Abdi Ali A, Al Hamoud Al Asswad S, Lauschke VM, Forsman H, Dahlgren C, Johansson LC.   +6 more
europepmc   +1 more source

Assessing protein‐specific radiation damage in time‐resolved X‐ray solution‐scattering experiments at high‐brilliance synchrotrons using fast detector readout

Acta Crystallographica Section D, EarlyView.
Adenylate kinase was used to quantify how experimental parameters influence radiation damage during time‐resolved X‐ray solution scattering (TR‐XSS) at a multipurpose SAXS beamline. The study provides general guidelines for minimizing radiation artifacts in TR‐XSS.Time‐resolved X‐ray solution scattering (TR‐XSS) enables tracking of protein structural ...
Fatemeh Sabzian-Molaei, Tomás S. Plivelic, Magnus Andersson   +2 more
wiley   +1 more source

On the relationship between efficiency and cooperativity in multi-subunit molecular machines. [PDF]

Protein Sci
Ben-Maimon M, Horovitz A.
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source