Results 251 to 260 of about 137,279 (309)

Structure-Based Identification of Allosteric Glucocerebrosidase Stabilizers from <i>Xylia xylocarpa</i> (Roxb.) Taub. for Parkinson's Disease Using LC-MS Profiling and Computational Analysis. [PDF]

Plants (Basel)
Ebrahim Thaivalappil IA, Mohan A, Nadh AG, Raju R, Ahmed MG.   +4 more
europepmc   +1 more source

Computational Identification of Potential Novel Allosteric IHF Inhibitors Using QSAR Modeling to Inhibit Plasmid-Mediated Antibiotic Resistance. [PDF]

Int J Mol Sci
Saurith-Coronell O, Sierra-Hernandez O, Rodríguez-Macías JD, Mora JR, Perez-Perez N, Alcázar JJ, Moura RO, Nascimento IJDS, Márquez Brazón EA, Marrero-Ponce Y.   +9 more
europepmc   +1 more source

Mapping of dynamic allostery within p38 alpha kinase via network analyses and NMR spectroscopy

Linser R, Acharyya S, Weisner J, Bernardi R.   +3 more
europepmc   +1 more source

Correction for Jaen Maisonet et al., Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7). [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs

Journal of Molecular Biology, 2022
Here, we discuss the principles of allosteric activating mutations, propagation downstream of the signals that they prompt, and allosteric drugs, with examples from the Ras signaling network. We focus on Abl kinase where mutations shift the landscape toward the active, imatinib binding-incompetent conformation, likely resulting in the high affinity ATP
Ruth Nussinov, Mingzhen Zhang, Ryan Maloney   +2 more
exaly   +3 more sources

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Allosteric Methods and Their Applications: Facilitating the Discovery of Allosteric Drugs and the Investigation of Allosteric Mechanisms

Accounts of Chemical Research, 2019
Allostery, or allosteric regulation, is the phenomenon in which protein functional activity is altered by the binding of an effector at an allosteric site that is topographically distinct from the orthosteric, active site. As one of the most direct and efficient ways to regulate protein function, allostery has played a fundamental role in innumerable ...
Shaoyong Lu, Qiancheng Shen, Jian Zhang
openaire   +2 more sources

Allosteric Regulation of Proteases

ChemBioChem, 2008
AbstractAllostery is a basic principle of control of enzymatic activities based on the interaction of a protein or small molecule at a site distinct from an enzyme's active center. Allosteric modulators represent an alternative approach to the design and synthesis of small‐molecule activators or inhibitors of proteases and are therefore of wide ...
Hauske, Patrick, Otmann, Christian, Meltzer, Michael, Ehrmann, Michael, Kaiser, Markus   +4 more
openaire   +3 more sources

On the Allosteric Effect of nsSNPs and the Emerging Importance of Allosteric Polymorphism

Journal of Molecular Biology, 2019
The molecular mechanisms of pathological non-synonymous single-nucleotide polymorphisms are still the object of intensive research. To this end, we explore here whether non-synonymous single-nucleotide polymorphisms can work via allosteric mechanisms.
Wei-Ven, Tee, Enrico, Guarnera, Igor N, Berezovsky   +2 more
openaire   +2 more sources