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On the Allosteric Effect of nsSNPs and the Emerging Importance of Allosteric Polymorphism
Journal of Molecular Biology, 2019The molecular mechanisms of pathological non-synonymous single-nucleotide polymorphisms are still the object of intensive research. To this end, we explore here whether non-synonymous single-nucleotide polymorphisms can work via allosteric mechanisms.
Wei-Ven, Tee +2 more
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Allosteric Properties of Acetylcholinesterase
Nature New Biology, 1972SEVERAL reports1–3 have suggested that cholinergic ligands bind to acetylcholinesterase at sites distinct from the active centre. Changeux et al.4 demonstrated that acetylcholine binds to non-catalytic sites as well as to the active centre of the enzyme.
G, Kato, E, Tan, J, Yung
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An Allosteric Hammerhead Ribozyme
Nature Biotechnology, 1995We have constructed an RNA molecule containing a hammerhead ribozyme that is under allosteric control. In the inactive state, the RNA enzyme is unable to cleave a suitable substrate. The formation of the active state of the ribozyme is triggered by a specific interaction with a DNA oligonucleotide effector that is complementary to a single-stranded ...
H, Porta, P M, Lizardi
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Allosteric repression: An Analysis
Journal of Theoretical Biology, 1977Abstract A kinetic analysis of repression is presented based on the accepted sequence of molecular events and the assumption that the co-repressor-repressor interaction involves an allosteric transition. This leads to an expression which relates the two experimentally accessible variables—enzyme and signal—when the system is operating in vivo .
J A, Burns, H, Kacser
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Sigmoidicity in Allosteric Models
Mathematical Biosciences, 1983For the saturation function, the state function as well as for the steady-state rate function of the Monod-Wyman-Changeux allosteric model analytical conditions of sigmoidicity are derived. They are shown as regions of sigmoidicity in a parameter space constituted by the allosteric constant parameter and the nonexclusive binding coefficient for each ...
Demongeot, Jacques, Laurent, Michel
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A portable allosteric mechanism
Proteins: Structure, Function, and Bioinformatics, 2004Abstract The allosteric mechanism by which the gene expression regulatory protein AraC regulates its DNA‐binding activity is shown to be portable by grafting it to β‐galactosidase, generating an arabinose‐regulated β‐galactosidase.
Urszula, Gryczynski, Robert, Schleif
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Thermodynamics of allosteric transitions
Journal of Theoretical Biology, 1977Abstract A new thermodynamic description of allosteric transitions in enzymes is introduced. Distinguished from previous approaches, the new method accounts for the effect of temperature on ligand binding affinities as well as the effect of ligand concentration. When applied to hemoglobin, the method yields a generalized Hill equation.
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Allosteric regulation of chaperonins
Current Opinion in Structural Biology, 2005Chaperonins are molecular machines that facilitate protein folding by undergoing energy (ATP)-dependent movements that are coordinated in time and space by complex allosteric regulation. Recently, progress has been made in describing the various functional (allosteric) states of these machines, the pathways by which they interconvert, and the coupling ...
Horovitz, A, Willison, KR
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Aptamers for allosteric regulation
Nature Chemical Biology, 2011Aptamers are useful for allosteric regulation because they are nucleic acid-based structures in which ligand binding induces conformational changes that may alter the function of a connected oligonucleotide at a distant site. Through this approach, a specific input is efficiently converted into an altered output.
Vinkenborg, J. +2 more
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Overview of Receptor Allosterism
Current Protocols in Pharmacology, 2010AbstractIn addition to the orthosteric site, which recognizes endogenous ligands, most G protein–coupled receptors (GPCRs) possess topographically distinct allosteric sites that can be recognized by small molecules and accessory cellular proteins. Ligand binding to allosteric sites promotes a conformational change in the GPCR that can alter orthosteric
Karen J, Gregory +2 more
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