Results 261 to 270 of about 137,279 (309)
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Computational elucidation of allosteric communication in proteins for allosteric drug design
Drug Discovery Today, 2022Allosteric modulators target topologically distal allosteric sites in order to modulate orthosteric sites, providing enhanced specificity and physiochemical properties. Harnessing allostery for drug discovery is an emerging paradigm in modern pharmaceutics.
Duan Ni, Ren Kong, Shaoyong Lu
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Allosteric repression: An Analysis
Journal of Theoretical Biology, 1977Abstract A kinetic analysis of repression is presented based on the accepted sequence of molecular events and the assumption that the co-repressor-repressor interaction involves an allosteric transition. This leads to an expression which relates the two experimentally accessible variables—enzyme and signal—when the system is operating in vivo .
J A, Burns, H, Kacser
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Olfaction: Allosteric modulation
Current Biology, 2023New research indicates that the odor-evoked responses of human olfactory receptors can be enhanced via the non-competitive binding of an allosteric modulator. This modulatory mechanism adds an additional layer of complexity to the peripheral encoding of odors.
Samuel, Caton, Adam, Dewan
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An Allosteric Hammerhead Ribozyme
Nature Biotechnology, 1995We have constructed an RNA molecule containing a hammerhead ribozyme that is under allosteric control. In the inactive state, the RNA enzyme is unable to cleave a suitable substrate. The formation of the active state of the ribozyme is triggered by a specific interaction with a DNA oligonucleotide effector that is complementary to a single-stranded ...
H, Porta, P M, Lizardi
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Artificial Allosteric Receptors
Chemistry – A European Journal, 2013AbstractCooperative effects in the binding of two or more substrates to different binding sites of a receptor that are a result of a conformational change caused by the binding of the first substrate—also referred to as the effector—are called allosteric effects.
Christopher, Kremer, Arne, Lützen
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Allosteric regulation of chaperonins
Current Opinion in Structural Biology, 2005Chaperonins are molecular machines that facilitate protein folding by undergoing energy (ATP)-dependent movements that are coordinated in time and space by complex allosteric regulation. Recently, progress has been made in describing the various functional (allosteric) states of these machines, the pathways by which they interconvert, and the coupling ...
Horovitz, A, Willison, KR
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Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator
Biochemistry, 2023The NTSR1 neurotensin receptor (NTSR1) is a G protein-coupled receptor (GPCR) found in the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide ligand. In the brain, NTS modulates dopamine neuronal activity, induces opioid-independent analgesia, and regulates food intake.
Brian E. Krumm +14 more
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Progress in Allosteric Database
2019An allosteric mechanism refers to the biological regulation process wherein macromolecules propagate the effect of ligand binding at one site to a spatially distant orthosteric locus, thus affecting activity. The theory has remained a trending topic in biology research for over 50 years, since the understanding of allostery is fundamental for gleaning ...
Kun, Song, Jian, Zhang, Shaoyong, Lu
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Aptamers for allosteric regulation
Nature Chemical Biology, 2011Aptamers are useful for allosteric regulation because they are nucleic acid-based structures in which ligand binding induces conformational changes that may alter the function of a connected oligonucleotide at a distant site. Through this approach, a specific input is efficiently converted into an altered output.
Vinkenborg, J. +2 more
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Overview of Receptor Allosterism
Current Protocols in Pharmacology, 2010AbstractIn addition to the orthosteric site, which recognizes endogenous ligands, most G protein–coupled receptors (GPCRs) possess topographically distinct allosteric sites that can be recognized by small molecules and accessory cellular proteins. Ligand binding to allosteric sites promotes a conformational change in the GPCR that can alter orthosteric
Karen J, Gregory +2 more
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