The endocannabinoid hydrolase FAAH is an allosteric enzyme. [PDF]
Sci Rep, 2020 Dainese E +9 more
europepmc +4 more sources
Allosteric regulation of epigenetic modifying enzymes [PDF]
Current Opinion in Chemical Biology, 2017 Epigenetic enzymes including histone modifying enzymes are key regulators of gene expression in normal and disease processes. Many drug development strategies to target histone modifying enzymes have focused on ligands that bind to enzyme active sites, but allosteric pockets offer potentially attractive opportunities for therapeutic development. Recent
Beth E, Zucconi, Philip A, Cole
openaire +4 more sources
Allosteric Enzyme-Based Biosensors—Kinetic Behaviours of Immobilised L-Lysine-α-Oxidase from Trichoderma viride: pH Influence and Allosteric Properties [PDF]
Biosensors, 2020 The present study describes the kinetics of L-lysine-α-oxidase (LO) from Trichoderma viride immobilised by co-crosslinking onto the surface of a Pt electrode. The resulting amperometric biosensor was able to analyse L-lysine, thus permitting a simple but
Antonio Guerrieri +4 more
doaj +2 more sources
Author Correction: The endocannabinoid hydrolase FAAH is an allosteric enzyme. [PDF]
Sci Rep, 2020 Dainese E +9 more
europepmc +3 more sources
Redesigning allosteric activation in an enzyme [PDF]
Proceedings of the National Academy of Sciences, 2011 Enzyme activation by monovalent cations is widely documented in plants and the animal world. In type II enzymes, activation entails two steps: binding of the monovalent cation to its allosteric site and transduction of this event into enhanced catalytic activity.
Sadhna, Rana +3 more
openaire +4 more sources
Allosteric enzymes as biosensors for molecular diagnosis [PDF]
FEBS Letters, 2003 Biosensors are hybrid analytical devices that amplify signals generated from the specific interaction between a receptor and the analyte, through a biochemical mechanism. Biosensors use tissues, whole cells, artificial membranes or cell components like proteins or nucleic acids as receptors, coupled to a physicochemical signal transducer.
Antonio Villaverde
openaire +4 more sources
Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2017 The first enzyme of the shikimate pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS), adopts a range of distinct allosteric regulation mechanisms in different organisms, related to different quaternary assemblies.
Wanting Jiao +3 more
doaj +3 more sources
The ideal allosteric enzyme [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 1996 W. N. Liscomb
openaire +2 more sources
Dissecting the Allosteric Fine-Tuning of Enzyme Catalysis
JACS AuFully understanding the mechanism of allosteric regulation in biomolecules requires separating and examining all of the involved factors. In enzyme catalysis, allosteric effector binding shifts the structure and dynamics of the active site, leading to modified energetic (e.g., energy barrier) and dynamical (e.g., diffusion coefficient) factors ...
Xin-Qiu Yao, Donald Hamelberg
doaj +3 more sources
Coevolution-based prediction of key allosteric residues for protein function regulation
eLife, 2023 Allostery is fundamental to many biological processes. Due to the distant regulation nature, how allosteric mutations, modifications, and effector binding impact protein function is difficult to forecast.
Juan Xie +4 more
doaj +1 more source