The endocannabinoid hydrolase FAAH is an allosteric enzyme. [PDF]
Sci Rep, 2020 Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that in vivo controls content and biological activity of N-arachidonoylethanolamine (AEA) and other relevant bioactive lipids termed endocannabinoids.
Dainese E +9 more
europepmc +11 more sources
Patterns of Spatiotemporal Organization in an Allosteric Enzyme Model [PDF]
Proceedings of the National Academy of Sciences, 1973 The behavior of a model for an allosteric enzyme oscillator activated by the reaction product is analyzed in the presence of diffusion. When the concentrations of the chemicals are fixed at the boundaries, dynamic dissipative structures are shown to ...
Albert Goldbeter
semanticscholar +6 more sources
Allosteric Enzyme-Based Biosensors—Kinetic Behaviours of Immobilised L-Lysine-α-Oxidase from Trichoderma viride: pH Influence and Allosteric Properties [PDF]
Biosensors, 2020 The present study describes the kinetics of L-lysine-α-oxidase (LO) from Trichoderma viride immobilised by co-crosslinking onto the surface of a Pt electrode. The resulting amperometric biosensor was able to analyse L-lysine, thus permitting a simple but
Antonio Guerrieri +4 more
doaj +4 more sources
Uncoupling conformational states from activity in an allosteric enzyme. [PDF]
Nat Commun, 2017 ATP-phosphoribosyltransferase (ATP-PRT) is a hexameric enzyme in conformational equilibrium between an open and seemingly active state and a closed and presumably inhibited form. The structure-function relationship of allosteric regulation in this system
Pisco JP +8 more
europepmc +2 more sources
Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity. [PDF]
Sci Rep, 2016 L-asparaginase (L-ASNase) (EC 3.5.1.1) is an important enzyme for the treatment of acute lymphoblastic leukaemia. Currently, the enzyme is obtained from bacteria, Escherichia coli and Erwinia chrysanthemi.
Costa IM +7 more
europepmc +2 more sources
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. [PDF]
Structure, 2004 Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. The molecular basis for these two properties is not well understood.
K. Kamata +4 more
semanticscholar +4 more sources
DNA Detection and Signal Amplification via an Engineered Allosteric Enzyme [PDF]
Journal of the American Chemical Society, 2002 Rapid, sensitive, and sequence-specific DNA detection can be achieved in one step using an engineered intrasterically regulated enzyme. The semi-synthetic inhibitor-DNA-enzyme (IDE) construct (left) rests in the inactive state but upon exposure to a ...
Alan Saghatelian +3 more
openalex +2 more sources
Redesigning allosteric activation in an enzyme [PDF]
Proceedings of the National Academy of Sciences, 2011 Enzyme activation by monovalent cations is widely documented in plants and the animal world. In type II enzymes, activation entails two steps: binding of the monovalent cation to its allosteric site and transduction of this event into enhanced catalytic activity.
Sadhna Rana +3 more
openalex +5 more sources
Comparison of Plant-Type Phospho enol pyruvate Carboxylases from Rice: Identification of Two Plant-Specific Regulatory Regions of the Allosteric Enzyme [PDF]
Plant and Cell Physiology, 2014 Phosphoenolpyruvate carboxylase (PEPC) is a key enzyme of primary metabolism in bacteria, algae and vascular plants, and it undergoes allosteric regulation by various metabolic effectors.
Masayuki Muramatsu +3 more
openalex +2 more sources
Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation [PDF]
Journal of Biological Chemistry, 2009 The mechanism by which the enzyme pyruvate decarboxylase from two yeast species is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants, or of enzyme complexes from two yeast ...
S. Kutter +5 more
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