Results 91 to 100 of about 57,293 (304)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

A Comparative Analysis of Michaelis-Menten, Hill, and Allosteric Models in Drug Metabolism

Iraqi Journal of Industrial Research
Background: Enzyme Kinetics it is a fundamental part of metabolic biochemistry because it helps to explore the mechanism of action and interaction of all substrates under the influence as well as environmental factors.
Ziyad K. Radeef
doaj   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Domain cross-talk within a bifunctional enzyme provides catalytic and allosteric functionality in the biosynthesis of aromatic amino acids [PDF]

, 2019
Yu Bai, Eric J. M. Lang, Ali Reza Nazmi, Emily J. Parker   +3 more
openalex   +1 more source

Nanozyme Microrobots: Programmable Spatiotemporal Catalysis for Targeted Therapy and Diagnostics

Advanced Science, EarlyView.
This review presents nanozyme microrobots as emerging catalytic systems that integrate mobility, external actuation, and adaptive reactivity to achieve precise biochemical functions. By examining mobility‐regulated catalysis, spatial targeting, integrated designs, and translational demonstrations, the article highlights how nanozyme robotics enables ...
Hong Huy Tran, Nil Kanatha Pandey, David P. Cormode, Daeyeon Lee, Edward Steager, Hyun Koo   +5 more
wiley   +1 more source

Modeling the contribution of allosteric regulation for flux control in the central carbon metabolism of E. coli

Frontiers in Bioengineering and Biotechnology, 2015
Modeling metabolism is fundamental for cell factory design. Central carbon metabolism (CCM) is particularly important as it provides the energy and precursors for other biological processes.
Daniel eMachado, Markus J Herrgard, Isabel eRocha   +2 more
doaj   +1 more source

Allosteric Properties of Cyanobacterial Cytochrome c Oxidase: Inhibition of the Coupled Enzyme by ATP and Stimulation by ADP [PDF]

, 1999
Daniel L. Alge, Marnik Wastyn, Christian Mayer, Christian Jungwirth, Ulrike Zimmermann, Roland Zoder, Susanne Fromwald, Günter A. Peschek   +7 more
openalex   +1 more source

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate [PDF]

, 2020
H. YOSHIOKA, Hudson W. Coates, Ngee Kiat Chua, Yuichi Hashimoto, Andrew J. Brown, Kenji Ohgane   +5 more
openalex   +1 more source

Angiotensin I–Converting Enzyme Inhibitors Are Allosteric Enhancers of Kinin B1 and B2 Receptor Function [PDF]

, 2010
Ervin G. Erdös, Fulong Tan, Randal A. Skidgel   +2 more
openalex   +1 more source

Regulation of surface-membrane enzymes by lipid ordering. A model based on allosteric transition theory [PDF]

, 1983
P. Blanquet
openalex   +1 more source