Results 101 to 110 of about 2,040,864 (360)
Biochemical Journal, 1976 The steady-state equations for "random" enzymic mechanisms (ones with alternative routes for substrate and enzyme to form enzyme-substrate complexes) are non-Michaelian and very complicated when a quasi-equilibrium approximation cannot be used.
E. Whitehead
semanticscholar +1 more source
A model for the allosteric regulation of pH-sensitive enzymes [PDF]
Biochemical Journal, 1977 1. In an enzyme that has two independent binding sites for a ligand, any inhibitor that binds solely to the free enzyme will give rise to positive co-operativity. 2. A model is considered for the allosteric control of enzymes by effectors in which their effects are mediated by ligand-induced perturbations of the ionization constants of a group or ...
K F Tipton, J S Shindler
openaire +3 more sources
Inhibition of a viral enzyme by a small-molecule dimer disruptor. [PDF]
, 2009 We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi's sarcoma-associated herpesvirus (KSHV) by screening an alpha-helical mimetic library.
Arnold, Leggy A +7 more
core
Advanced Science, EarlyView.This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz +14 more
wiley +1 more source
Identification of the allosteric regulatory site of insulysin. [PDF]
PLoS ONE, 2011 Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and
Nicholas Noinaj +7 more
doaj +1 more source
Combinatorial Control through Allostery [PDF]
, 2018 Many instances of cellular signaling and transcriptional regulation involve switch-like molecular responses to the presence or absence of input ligands. To understand how these responses come about and how they can be harnessed, we develop a statistical ...
Einav, Tal +3 more
core +6 more sources
An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum
Advanced Science, EarlyView.This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang +11 more
wiley +1 more source
Thermodynamic and Kinetic Analysis of Sensitivity Amplification in Biological Signal Transduction [PDF]
, 2002 Based on a thermodynamic analysis of the kinetic model for the protein phosphorylation-dephosphorylation cycle, we study the ATP (or GTP) energy utilization of this ubiquitous biological signal transduction process.
Bourne +23 more
core +5 more sources
Advanced Science, EarlyView.The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang +15 more
wiley +1 more source
A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 The discovery of allosteric modulators is a multi-disciplinary approach, which is time- and cost-intensive. High-throughput screening combined with novel computational tools can reduce these factors. Thus, we developed an enzyme activity assay, which can
Ariane Menden +7 more
doaj +1 more source