Results 141 to 150 of about 2,040,864 (360)
Biomolecular Interaction Prediction: The Era of AI
Advanced Science, EarlyView.This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley +1 more source
Dynamic regulation of phenylalanine hydroxylase
Pteridines, 2014 Phenylalanine hydroxylase (PAH) is the key enzyme in phenylalanine metabolism, catalyzing its oxidative breakdown to tyrosine. Its function in the committed step of amino acid metabolism requires strict regulation. Thus, several regulatory mechanisms are
Fuchs Julian E. +2 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2015 Modeling metabolism is fundamental for cell factory design. Central carbon metabolism (CCM) is particularly important as it provides the energy and precursors for other biological processes.
Daniel eMachado +2 more
doaj +1 more source
Advanced Electronic Materials, EarlyView.The single‐molecule with a large transistor‐SiMoT is proposed for the detection of the subgenomic RNA of SARS‐CoV‐2, achieving a diagnostic sensitivity of 98.0% and a specificity of 87.8%. The SiMoT technology, currently at TRL‐5, is suitable for point‐of‐care settings and delivers the result to the end user in 30 min.
Eleonora Macchia +12 more
wiley +1 more source
The nature of the inhibition and activation of epidermal phosphofructokinase: an allosteric enzyme.
Journal of Investigative Dermatology, 1972 Phosphofructokinase (PFK) was partially purified (× 50) from rhesus monkey epidermis. Kinetic studies showed a biphasic regulation of this enzyme by ATP, i.e., activation at low concentrations and inhibition at high concentrations. The partially purified
S. Kondo, K. Adachi
semanticscholar +1 more source
The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B)
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Glycogen storage disorders are a group of genetic disorders affecting glucose homeostasis in the body. Muscular glycogen stores are essential for liberating glucose for energy supply during bursts of activity and sustained muscle work. Muscle glycogen storage disease 0 (GSD0B) is associated with biallelic variants in GYS1 causing muscular ...
Sarah Donoghue +16 more
wiley +1 more source
iScience, 2020 Summary: Insulin regulates glucose metabolism through thousands of regulatory mechanisms; however, which regulatory mechanisms are keys to control glucose metabolism remains unknown.
Satoshi Ohno +10 more
doaj
Prediction and confirmation of a switch-like region within the N-terminal domain of hSIRT1
Biochemistry and Biophysics Reports, 2022 Many proteins display conformational changes resulting from allosteric regulation. Often only a few residues are crucial in conveying these structural and functional allosteric changes.
Angelina T. Huynh +10 more
doaj
Elution of pyruvate kinase from cm‐cellulose columns by its allosteric effector. A novel method For enzyme purification [PDF]
, 1969 Héctor Carminatti +2 more
openalex +1 more source
Annals of Neurology, EarlyView.Objective The objective of this study was to show the capacity of structural brain magnetic resonance imaging (MRI) measures to serve as monitoring biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome (FXTAS). Methods From 2 longitudinal studies of male FMR1 premutation carriers, 2 brain MRI scans were selected from each participant, collected ...
David Hessl +6 more
wiley +1 more source