Results 151 to 160 of about 57,293 (304)

Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP⁺-Dependent Malic Enzyme 1

, 2022
Tomohiro Yoshida, Tetsuhiro Kawabe, Lewis C. Cantley, Costas A. Lyssiotis   +3 more
openalex   +2 more sources

The Oxytocin Receptor in Spermatozoa May Originate From Both Spermatogenesis and Epididymal Maturation, and Regulates Capacitation

Andrology, EarlyView.
Abstract Background The oxytocin receptor (OR) is a G‐protein‐coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown. Objectives In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate ...
Jesús Martínez‐Hernández, Ferran Garriga, Adeel Ahmad, Lorena Padilla, Carolina Maside, Sergi Bonet, Isabel Barranco, Jordi Roca, Luis Miguel Pastor, Marc Yeste   +9 more
wiley   +1 more source

The details and entropy demons in a transmembrane allosteric machine. [PDF]

PLoS Biol
Luisi BF.
europepmc   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Allostery-Driven Substrate Gating in the Chlorothalonil Dehalogenase from <i>Pseudomonas</i> sp. CTN-3. [PDF]

Biology (Basel)
Gerlich G, Klein-Seetharaman J, Holz RC.
europepmc   +1 more source

Exploring Allosteric Pathways of a V-Type Enzyme with Dynamical Perturbation Networks

, 2019
Aria Gheeraert, Lorenza Pacini, Víctor S. Batista, Laurent Vuillon, Claire Lesieur, Ivan Rivalta   +5 more
openalex   +2 more sources

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme [PDF]

, 2018
Zongyang Lv, Lingmin Yuan, James H. Atkison, Katelyn Williams, Ramir Vega, E. Hampton Sessions, Daniela Divlianska, Christopher Davies, Yuan Chen, Shaun K. Olsen   +9 more
openalex   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Dynamic claw of dengue protease unveils druggability potential with high affinity allosteric inhibitors. [PDF]

PNAS Nexus
Bhunia M, Misra R, Maity A, Mohid SA, Kundu S, Bhunia A, Maiti NC, Pal U.   +7 more
europepmc   +1 more source

Allosteric Inhibitory Molecular Recognition of a Photochromic Dye by a Digestive Enzyme: Dihydroindolizine makes α-chymotrypsin Photo-responsive [PDF]

, 2016
Damayanti Bagchi, Abhijit Ghosh, Priya Singh, Shreyasi Dutta, Nabarun Polley, Ismail Althagafi, Rabab S. Jassas, Saleh A. Ahmed, Samir Kumar Pal   +8 more
openalex   +1 more source