Results 181 to 190 of about 2,040,864 (360)

Yeast Chorismate Mutase: Molecular Evolution of an Allosteric Enzyme [PDF]

, 2003
Kerstin Helmstaedt
openalex   +1 more source

Microfluidic‐Assisted Evolution of a Robust NAD+‐Dependent Enzyme with Improved Isobutanol Tolerance at Elevated Temperatures

ChemSusChem, EarlyView.
Utilizing the power of the absorbance‐activated droplet sorter, a key enzyme for a cell‐free multienzymatic cascade for sustainable isobutanol biosynthesis is optimized for improved thermostability and isobutanol tolerance required for efficient cascade performance.
Mariko Teshima, Robert Genth, Tenuun Bayaraa, Manuel Döring, Barbara Beer, Gerhard Schenk, Volker Sieber   +6 more
wiley   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

Thrombin: a paradigm for enzymes allosterically activated by monovalent cations [PDF]

, 2004
Enrico Di
openalex   +1 more source

Computational modelling of myocardial metabolism in patients with advanced heart failure

European Journal of Heart Failure, EarlyView.
LV, left ventricular; LVAD, left ventricular assist device; LVEF, left ventricular ejection fraction. Abstract Aims Perturbations of myocardial metabolism and energy depletion are well‐established hallmarks of heart failure (HF), yet methods for their systematic assessment remain limited in humans.
Niklas Beyhoff, Vera M. Braun, Marieluise Kirchner, Lucy E.M. Finnigan, Christoph Knosalla, István Baczkó, Evgenij Potapov, Ulrich Kintscher, Tilman Grune, Titus Kuehne, Hermann‐Georg Holzhütter, Philipp Mertins, Damian J. Tyler, Hendrik Milting, Betty Raman, Oliver J. Rider, Stefan Neubauer, Nikolaus Berndt   +17 more
wiley   +1 more source

Mutation of Active Site Residues of Insulin-degrading Enzyme Alters Allosteric Interactions [PDF]

, 2005
Eun Suk Song, Abigail Daily, Michael G. Fried, María A. Juliano, Luiz Juliano, Louis B. Hersh   +5 more
openalex   +1 more source

The ideal allosteric enzyme [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1996
openaire   +2 more sources

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Heart phosphofructokinase. Allosteric kinetics following affinity labeling modification of the enzyme by 8-[m-(m-fluorosulfonylbenzamido) benzylthio] adenine.

, 1978
Tag E. Mansour, Todd M. Martensen
openalex   +1 more source

Characterization of the functional role of allosteric site residue Asp102 in the regulatory mechanism of human mitochondrial NAD(P)+-dependent malate dehydrogenase (malic enzyme) [PDF]

, 2005
Hui‐Chih Hung, Meng-Wei Kuo, Gu‐Gang Chang, Guang‐Yaw Liu   +3 more
openalex   +1 more source