Results 181 to 190 of about 57,293 (304)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Identification of Alternative Allosteric Sites in Glycolytic Enzymes for Potential Use as Species-Specific Drug Targets

, 2020
Merve Ayyildiz, Serkan Çeliker, Fatih Ozhelvaci, Ebru Demet Akten   +3 more
openalex   +1 more source

Distinct Roles for CTD Ser-2 and Ser-5 Phosphorylation in the Recruitment and Allosteric Activation of Mammalian mRNA Capping Enzyme [PDF]

, 1999
C. Kiong Ho, Stewart Shuman
openalex   +1 more source

A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures

Epilepsia, EarlyView.
A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures. Abstract Objectives This randomized, double‐blind, placebo‐controlled study (NCT04557085), conducted in China, Japan, and the Republic of Korea, evaluated the efficacy and safety of ...
Sang Kun Lee, Peimin Yu, Eunyeong Choe, Louis Ferrari, Kyoung Heo, Seung Bong Hong, Zhen Hong, Koji Iida, Yong Heui Jeon, Jiwon Jung, Marc Kamin, Kensuke Kawai, Ji Hyun Kim, Myung Won Kim, Xiaorong Liu, Jungshin Park, William E. Rosenfeld, Takamichi Yamamoto, Dong Zhou, Suiqiang Zhu, Sunita N. Misra   +20 more
wiley   +1 more source

Identification of Sulfonamide-Vinyl Sulfone/Chalcone and Berberine-Cinnamic Acid Hybrids as Potent DENV and ZIKV NS2B/NS3 Allosteric Inhibitors. [PDF]

Int J Mol Sci
Mahalapbutr P, Hengphasatporn K, Manimont W, Vajarintarangoon L, Shigeta Y, Bhat N, Aiebchun T, Nutho B, Hannongbua S, Rungrotmongkol T.   +9 more
europepmc   +1 more source

[Allosteric enzymes].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1970
openaire   +1 more source

Enzymology: allosteric enzymes

, 2018
openaire   +1 more source

Modifying inhibitor specificity for homologous enzymes by machine learning

The FEBS Journal, EarlyView.
We present a machine learning method for the design of selective enzyme inhibitors, reducing experimental effort thus accelerating the development of targeted therapeutics. Trained on existing data for three related matrix metalloproteinases (MMPs), our method successfully designed a novel inhibitor variant with enhanced selectivity for one MMP over ...
Dor S. Gozlan, Reut Meiri, Gili Shapira, Matt Coban, Evette S. Radisky, Yaron Orenstein, Niv Papo   +6 more
wiley   +1 more source

Unprecedented allosteric inhibition of <i>E. coli</i> malate dehydrogenase by silver(i) from atomic resolution analysis. [PDF]

Chem Sci
Wang H, Wang M, Yang X, Yan A, Hao Q, Li H, Sun H.   +6 more
europepmc   +1 more source

Structural analysis of the NifL‐NifA complex reveals the molecular basis of anti‐activation of nitrogen fixation gene expression in Azotobacter vinelandii

The FEBS Journal, EarlyView.
Using cryo‐EM combined with biochemical and genetic approaches, we mapped the interaction surface between NifL and NifA to gain insights into the regulation of nitrogen fixation genes in A. vinelandii. Our findings suggest that NifL, a homolog of histidine kinases lacking phosphorylation activity, evolved to act as a steric block of NifA activity ...
Marcelo Bueno Batista, Jake Richardson, Michael W. Webster, Dmitry Ghilarov, John W. Peters, David M. Lawson, Ray Dixon   +6 more
wiley   +1 more source