Results 191 to 200 of about 57,293 (304)

Selective Identification of Allosteric Inhibitors and Co-Drug Combinations Targeting Kinases by Using a Nanopore Tweezer Approach. [PDF]

ACS Nano
Li F, Foster JC, Nguyen L, Chen M.
europepmc   +1 more source

High-PerformanceBiosensing Platforms Based on Enzyme-LinkedNucleic Acid Amplification Regulated by Synergistic Allosteric HairpinCatalysis of Bimetallic Nanozymes and Its Mechanisms

Yunzhi Ma (4951102), Chenchen Jin (21011024), Feiyan Yan (7847705), Yeyu Wu (17272624), Jun Yan (28467), Ke-Jing Huang (4029731), Yu Ya (21011027), Xuecai Tan (2867768)   +7 more
openalex   +1 more source

DNA Detection and Signal Amplification via an Engineered Allosteric Enzyme

, 2002
Alan Saghatelian, Kevin M. Guckian, Desiree A. Thayer, M. Reza Ghadiri   +3 more
openalex   +2 more sources

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Natural Fatty Acids as Dual ACE2-Inflammatory Modulators: Integrated Computational Framework for Pandemic Preparedness. [PDF]

Int J Mol Sci
Lituma-González WD, Ballaz S, Verma T, Sasikumar JM, Lakshmanan S.   +4 more
europepmc   +1 more source

Cooperativity of Allosteric Enzymes Involving the Stable Enzyme-Intermediate

Seibutsu Butsuri, 1987
Kojiro TAKAHASHI, Shigehiko TANIGUCHI
openaire   +2 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Allosteric Mechanisms Triggering Substrate and Cofactor Binding in the SULT1A1 Dimer as Revealed by Molecular Dynamics Simulations. [PDF]

J Chem Inf Model
Toth D, Dudas B, Nicot AB, Miteva MA, Balog E.   +4 more
europepmc   +1 more source

Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35

The FEBS Journal, EarlyView.
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima, Sayako Shimomura, Mayuka Wakabayashi, Wei Qi Loh, Harumi Ando, Haruka Sei, Hiroyuki Hattori, Didik Huswo Utomo, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata   +11 more
wiley   +1 more source

Emerging structural insights into PRC2 function in development and disease. [PDF]

Trends Biochem Sci
Bhat MY, Liu X.
europepmc   +1 more source