Results 211 to 220 of about 2,040,864 (360)

Structural identification of the pathway of long-range communication in an allosteric enzyme

Proceedings of the National Academy of Sciences of the United States of America, 2008
Prafull S Gandhi, Zhiwei Chen, F. Mathews, E. Di Cera   +3 more
semanticscholar   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

, 2003
James R. Burke, Mark A. Pattoli, Kurt R. Gregor, Patrick Brassil, John F. MacMaster, Kim W. McIntyre, Xiaoxia Yang, Violetta S. Iotzova, Wendy Clarke, Joann Strnad, Yuping Qiu, F. Christopher Zusi   +11 more
openalex   +1 more source

Designing Allosteric Control into Enzymes by Chemical Rescue of Structure [PDF]

, 2012
Katelyn Deckert, S. Jimmy Budiardjo, Luke C. Brunner, Scott Lovell, John Karanicolas   +4 more
openalex   +1 more source

Progress in Molecular Imprinting—From Inhibition of Enzymatic Activity to Regulation of Cellular Pathways

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular imprinting is a very powerful tool in life science. The research areas benefiting from a wide range of capabilities of molecularly imprinted polymeric nanoparticles (nanoMIPs) include sample preparation, extraction, sensing/detection, diagnostics, and drug delivery.
Milada Vodova, Jaroslava Bezdekova, Marketa Vaculovicova   +2 more
wiley   +1 more source

Single Enzyme Studies Reveal the Existence of Discrete Functional States for Monomeric Enzymes and How They Are “Selected” upon Allosteric Regulation [PDF]

, 2012
Nikos S. Hatzakis, Li W, Sune K. Jørgensen, Andreas H. Kunding, Pierre‐Yves Bolinger, Nicky Ehrlich, Ivan Makarov, Michael Skjøt, Allan Svendsen, Per Hedegård, Dimitrios Stamou   +10 more
openalex   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Discovery of novel allosteric inhibitors of HCV NS3/4a enzyme via structure-based drug design [PDF]

, 2012
Puja Pathuri, S. Saalau-Bethell, Andrew Woodhead, Maria G. Carr, Gianni Chessari, Joe Coyle, Martyn Frederickson, Brent Graham, C. Hamlett, S. Hiscock, Finn P. Holding, Harren Jhoti, Rachel McMenamin, Christopher W. Murray, Michael Reader, David C. Rees, Sharna J. Rich, Caroline J. Richardson, N. Thompson, Marcel L. Verdonk, M. Vinković, Paul A. Williams, Jeannine M. Yon   +22 more
openalex   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Trikafta Rescues F508del‐CFTR by Tightening Specific Phosphorylation‐Dependent Interdomain Interactions

Natural Sciences, EarlyView.
The most common cystic fibrosis mutation, F508del, destabilizes the first of two nucleotide‐binding domains (NBD1 and NBD2) and compromises Mg/ATP‐dependent gating at the interface between two transmembrane domains (TMD1 and TMD2) in the human cystic fibrosis transmembrane conductance regulator (CFTR).
Guangyu Wang
wiley   +1 more source