Results 221 to 230 of about 57,293 (304)

Calmodulin‐Like Protein MfCML50 Interacts With Carveol Dehydrogenase in Medicago falcata to Regulate Cold Tolerance Through Mediating ROS Homeostasis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Low temperature triggers Ca2+ signalling and reprogramming of gene expression and metabolism in plants. However, how the Ca2+ signal is transduced to the downstream metabolic pathways remains unknown. The involvement of a cold‐induced calmodulin‐like protein, MfCML50, from Medicago falcata in regulation of cold tolerance was examined in the ...
Bohao Geng, Shuhan Yu, Qiguo Sun, Lei Yang, Qian Yang, Hailong Yang, Zhenfei Guo   +6 more
wiley   +1 more source

Functional spectrum of USP7 pathogenic variants in Hao-Fountain syndrome: Insights into the enzyme's activity, stability, and allosteric modulation. [PDF]

Proc Natl Acad Sci U S A
Korchak EJ, Sharafi M, Jaen Maisonet I, Salazar-Chaparro A, Semenova IV, Khan H, O'Neil AL, Caro P, Schaaf CP, Buhrlage SJ, Bezsonova I.   +10 more
europepmc   +1 more source

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, EarlyView.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source

A Novel Allosteric Inhibitor Targeting IMPDH at Y233 Overcomes Resistance to Tyrosine Kinase Inhibitors in Lymphoma. [PDF]

Cancers (Basel)
Pattabiraman N, Lobello C, Rushmore D, Mologni L, Wasik M, Basappa J.   +5 more
europepmc   +1 more source

Mechanistic insights into catalysis and allosteric enzyme activation in bacteriophage lambda integrase.

, 2007
Hari Kamadurai
openalex   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors. [PDF]

Biochem J
Bunney TD, Nyvall HG, Macrae C, Lalović D, Gregory A, Le Huray KIP, Harvey N, Pinotsis N, Kalli AC, Waudby CA, Burke JE, Katan M.   +11 more
europepmc   +1 more source

In vitro quality assessment of red blood cells and plasma units in DEHT/SAGM bags and DEHT/PAGGSM bags during storage

Vox Sanguinis, EarlyView.
Abstract Background and Objectives DEHT is considered a safer alternative to DEHP, a commonly used plasticizer with potential toxicological risks. We aimed to compare the storage efficacy of red blood cells (RBCs) in DEHT bags containing two different additive solutions: SAGM and PAGGSM.
Anaïs Lotens, Tome Najdovski, Nicolas de Valensart, Nicolas Cellier, Chryslain Sumian, Quentin Brebant, Christian Naegelen, Constant Cretenet, Nadine Marpaux   +8 more
wiley   +1 more source

A flexible, allosteric loop regulates protein activity and rewires electrostatics. [PDF]

Protein Sci
Vera-Rodríguez DJ, Sapienza PJ, Popov KI, Lee AL.   +3 more
europepmc   +1 more source

Structure mirroring function: What's the ‘matter’ with the funny current?

The Journal of Physiology, EarlyView.
Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley   +1 more source