Results 231 to 240 of about 57,293 (304)

It Takes Two to Tango: Current Understanding of the Role of M16 Family of Proteases and Their Structural Properties. [PDF]

Biomolecules
Jarzab M, Skorko-Glonek J.
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Allosteric Ensembles Elucidate Mechanisms of Inhibition in Human Soluble Epoxide Hydrolase

Conte M, Qiu Q, Carmona OG, Abis G, Fraternali F.   +4 more
europepmc   +1 more source

S-allyl cysteine and alliin enhance catalase activity and prevent aggregation to counter oxidative stress in alzheimer's disease. [PDF]

Sci Rep
Yumlembam S, Singh K, Gupta A, Adhikarimayum P, Kumari A, Sarangthem K, Singh LR.   +6 more
europepmc   +1 more source

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

Synergistic regulatory mechanisms in glycolysis revealed by pathway transplantation. [PDF]

mBio
Knibbe E, Boonekamp FJ, Stuij R, Savakis P, Pelsma KAJ, Jansen L, Flores C-L, Teusink B, Daran-Lapujade P.   +8 more
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Allosteric pockets in the measles and Nipah virus polymerases: Mechanobiological insights and AI-driven drug discovery opportunities. [PDF]

Mechanobiol Med
Wang Y, Zhao L, Zhang H.
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

USP7 at the Crossroads of Ubiquitin Signaling, Cell Cycle, and Tumorigenesis. [PDF]

Molecules
Lusardi M, Rapetti F, Spallarossa A, Massone M, Cichero E, Brullo C.   +5 more
europepmc   +1 more source