ChemistryOpen, EarlyView.Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı +5 more
wiley +1 more source
The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The human peptidyl‐prolyl‐cis/trans isomerases (PPIases), Parvulin 14 and Parvulin 17, accelerate the cis/trans isomerization of Xaa‐Pro moieties within protein sequences. By modulating the respective binding interfaces of their target proteins, they play a crucial role in determining the fate of their substrates within the cell. Although both
Anna Sternberg +9 more
wiley +1 more source
Cooperativity of Allosteric Enzymes Involving the Stable Enzyme-Intermediate
Seibutsu Butsuri, 1987 Kojiro Takahashi, Shigehiko Taniguchi
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Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT ZraS is a metal sensor integral to ZraPSR, a two‐component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc‐induced stress on the bacterial envelope.
Nilima Mahapatra +3 more
wiley +1 more source
The more we learn, the more diverse it gets: structures, functions and evolution in the Phosphofructokinase Superfamily. [PDF]
Biochem JCompton JA, Patrick WM.
europepmc +1 more source
Design, synthesis, and anticancer activity evaluation of irreversible allosteric inhibitors of the ubiquitin-conjugating enzyme Ube2g2 [PDF]
, 2018 Chao Wang, Genbin Shi, Xinhua Ji
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Molecular Basis for Vacuolar Iron Transport by OsVIT2, a Target for Iron Biofortification in Rice
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Iron deficiency is the prevalent and most widespread nutritional shortfall for humans, affecting over 30% of the global population and leading to anemia, particularly among preschool‐aged children and pregnant women in developing countries. Simultaneously, while half of the world's population depends on rice (Oryza sativa L.) as a staple food,
L. B. Arend +4 more
wiley +1 more source
Allosteric modulation of Plasmodium falciparum Isoleucyl tRNA synthetase by South African natural compounds. [PDF]
PLoS OneChepsiror C +3 more
europepmc +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Protein–receptor interactions play a critical role in viral entry and pathogenesis. While ACE2 is the primary receptor for SARS‐CoV, the role of DPP4 as potential coreceptor remains underexplored. This study investigates the binding mechanisms and dissociation dynamics of the SARS‐CoV/DPP4, SARS‐CoV/ACE2 and MERS‐CoV/DPP4 complexes using ...
Patrícia Pereira Duzi Carvalho +1 more
wiley +1 more source
Gingerols and Shogaols of <i>Zingiber officinale var. sunti Valeton</i> as Potential Allosteric Agonists of Human GABA<sub>A</sub> Receptor by in silico Pharmacology Approach. [PDF]
J Exp PharmacolKuswandani F +6 more
europepmc +1 more source