Results 241 to 250 of about 57,293 (304)

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early‐onset sleep disruption in AD‐like amyloidogenic mice

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep–wake disturbances frequently occur at early stages of Alzheimer's disease (AD) and accelerate disease progression, but the underlying neural mechanisms are not fully understood. METHODS We examined sleep–wake behavior and locus coeruleus (LC) activity in young 5xFAD mice using electrophysiology and pharmacological approaches
Yi‐Ci Zhang, Xue‐Ting Zhang, Peng‐Yue Chen, Zi‐Yue Zhou, Mao‐Qing Huang, Kai‐Wen He   +5 more
wiley   +1 more source

Dynamics of single enzymes confined inside a nanopore. [PDF]

RSC Chem Biol
Galenkamp NS, van den Noort M, Maglia G.
europepmc   +1 more source

Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub‐Types

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 310-323, February 2026.
ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella, Sudeep Sarma, Caroline M. Hinesley, Corey E. Febo, Keith A. Breau, Deniz Durmusoglu, Ethan Purnell, Scott T. Magness, Carol K. Hall, Stefano Menegatti, Nathan Crook   +10 more
wiley   +1 more source

A dynamical-nonequilibrium molecular dynamics (D-NEMD) alanine scanning approach for identifying allosteric positions in proteins

Balega B, Beer M, Pike DT, Spencer J, Oliveira ASF, Mulholland AJ.   +5 more
europepmc   +1 more source

Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds. [PDF]

Front Pharmacol
Wiseman R, Thomas AG, Janiszewski J, Hoxie N, Lee CB, Wu Y, Tsukamoto T, Ye L, Ronzetti M, Shrimp JH, Adderley D, Rai G, Rais R, Alt J, Hall MD, Hu X, Kales SC, Slusher BS.   +17 more
europepmc   +1 more source

Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment. [PDF]

Expert Opin Ther Targets
Wu J, Tautz L.
europepmc   +1 more source

Allosteric regulation of L-lactate dehydrogenase: Beyond effector-mediated tetramerization. [PDF]

Protein Sci
Cai H, Shulami S, Štefanić Z, Hrenar T, Maršavelski A, Fishman A.   +5 more
europepmc   +1 more source

A genome-scale drug discovery pipeline uncovers therapeutic targets and a unique p97 allosteric binding site in <i>Schistosoma mansoni</i>. [PDF]

Proc Natl Acad Sci U S A
Stephens DR, Fung HYJ, Han Y, Liang J, Chen Z, Ready J, Collins JJ.   +6 more
europepmc   +1 more source

Phytochemical constituents of <i>Hydrangea macrophylla</i> var. <i>acuminata</i> leaves and their inhibitory activity against PTP1B and α-glucosidase. [PDF]

J Enzyme Inhib Med Chem
Pham TL, Nguyen VP, Nguyen TTA, Min BS, Kim JA.   +4 more
europepmc   +1 more source