Exploring the Hemoglobin T to R2 Path Using Gaussian Elastic Network Correlation Map Distance
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Proteins are dynamic and undergo conformational changes. These changes may affect the motions executed by different regions of the proteins and are reflected in the motion correlation map. A method to accurately measure these changes is presented and exemplified on a set of tetrameric Hemoglobin structures.
Yuval Valenci, Dror Tobi
wiley +1 more source
Uncovering the Role of Distal Regions in PDK1 Allosteric Activation. [PDF]
ACS Bio Med Chem AuMulpuri N, Yao XQ, Hamelberg D.
europepmc +1 more source
A model for the regulation of D‐3‐phosphoglycerate dehydrogenase, a Vmax‐type allosteric enzyme
Protein Science, 1996 G. A. Grant, D. Schuller, L. Banaszak
semanticscholar +1 more source
The regulation of enzyme activity and allosteric transition
Progress in Biophysics and Molecular Biology, 1970 openaire +3 more sources
Co-operative and allosteric enzymes: 20 years on [PDF]
European Journal of Biochemistry, 1987 Jacques Ricard, Athel Cornish-Bowden
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The SIRT1 N‐Terminal Domain as a Common Binding Interface for PPARγ Anchoring
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Insulin resistance, a global health threat linked to type 2 diabetes and obesity, can be addressed by modulating the activity of the Sirtuin 1 (SIRT1), a deacetylase that enhances insulin sensitivity by deacetylating the Peroxisome Proliferator‐Activated Receptor Gamma (PPARγ) at lysine 268 and 293. Understanding the binding interfaces between
Caique Camargo Malospirito +7 more
wiley +1 more source
Decoding allosteric landscapes: computational methodologies for enzyme modulation and drug discovery. [PDF]
RSC Chem BiolZhu R, Wu C, Zha J, Lu S, Zhang J.
europepmc +1 more source
New views on an old enzyme: allosteric regulation and evolution of archaeal pyruvate kinases [PDF]
, 2019 Ulrike Johnsen +6 more
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The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Watercress-derived glucosinolates as potential allosteric PTP1B inhibitors: a dual in silico and in vitro study on insulin signaling modulation. [PDF]
BMC ChemAhmed NA +8 more
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