Results 251 to 260 of about 2,040,864 (360)

Proteolytic stabilization of a spider venom peptide results in an orally active bioinsecticide

Pest Management Science, EarlyView.
Selective editing out of an insect gut protease cleavage site renders a spider‐derived insecticidal peptide active by ingestion by insect pests. Abstract BACKGROUND The toxin peptide U1‐AGTX‐Ta1b from the Hobo spider, Eratigena agrestis (Walckenaer, 1802), was studied to determine its potential to serve as a bioinsecticide.
Breck R. Davis, Alexandra M. Haase, Joseph S. Tourtois, Daniel L. Hulbert, Rachel E. Cornell, Brian T. DeVree, Cadence J. Flohrschutz, Lucille M. Bell, Daniel C. Peck, Trang T. Nguyen, Lin Bao, Robert M. Kennedy, Kyle D. Schneider   +12 more
wiley   +1 more source

Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody. [PDF]

Elife
Pinto Torres JE, Claes M, Hendrickx R, Yuan M, Smiejkowska N, Van Wielendaele P, Hacisuleyman A, De Winter H, Muyldermans S, Michels PAM, Walkinshaw MD, Versées W, Caljon G, Magez S, Sterckx YG.   +14 more
europepmc   +1 more source

Tailored Metal‐Organic Framework‐Based Enzyme Hybrids: Immobilization Strategies, Improved Performance, and Biological Applications

Small Science, EarlyView.
Metal‐organic frameworks (MOFs) offer versatile platforms for enzyme immobilization to overcome their inherent fragility. However, challenges such as restricted conformation and mass transfer limitations remain. Advances in precise MOF design can help overcome these obstacles, expanding their applicability across diverse fields, highlighting the ...
Xiang Xu, Jiacheng Wan, Jun Sun, Lina Wu, Jianping Lei   +4 more
wiley   +1 more source

Activation and Allostery in a Fungal SAMHD1 Hydrolase: An Evolutionary Blueprint for dNTP Catabolism. [PDF]

JACS Au
Pan L, Lachowicz JC, Paddy I, Xu Y, Yang Q, Zizola C, Milne A, Grove TL, Pandelia ME.   +8 more
europepmc   +1 more source

A Chemogenetic Toolkit for Inducible, Cell Type‐Specific Actin Disassembly

Small Methods, EarlyView.
ChiActs are novel actin‐perturbing genetic tools that can be rapidly activated by chemical actuators and optogenetically targeted to distinct subcellular locations using light. ChiActs rapidly induce actin disassembly in several model cell types and are able to perturb actin‐dependent nano‐assembly and cellular functions, including inhibition of ...
Tien‐Hung Lan, Nicholas Ambiel, Yi‐Tsang Lee, Tatsuki Nonomura, Yubin Zhou, J. Bradley Zuchero   +5 more
wiley   +1 more source

A Disease-Associated Mutation Impedes PPIA through Allosteric Dynamics Modulation. [PDF]

Biochemistry
Hattori Y, Kumashiro M, Kumeta H, Kyo T, Kawagoe S, Matsusaki M, Saio T.   +6 more
europepmc   +1 more source

A General Approach to Predict and Tailor the Nanoscale Permeability of Comb‐Shaped Polymer Coatings

Small Methods, EarlyView.
Comb‐shaped polymers are used to produce ‘molecular sieving’ coatings. The steric and size‐selective permeability characteristics of comb‐polymer coatings are systematically explored in silico across a very broad parameter space. All features of the data can be understood when three distinct regimes are considered: i) no‐interactions, ii) weak ...
Nicole Drossis, Marc A. Gauthier, Hendrick W. de Haan   +2 more
wiley   +1 more source

A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase. [PDF]

Protein Sci
Kinateder T, Drexler L, Duran C, Osuna S, Sterner R.   +4 more
europepmc   +1 more source

Design, Mechanisms, and Applications of DNA‐Mediated Dynamically Reconfigurable Plasmonic Gold Nanostructures

Small Methods, EarlyView.
This review provides key principles of designing and synthesizing reconfigurable plasmonic gold nanostructures for generating and controlling physical, chemical, and biological properties and functions. The recent advances in the biological and materials applications of dynamically reconfigurable plasmonic gold nanostructures are also summarized ...
So Young Choi, Jieun Kim, Eun Ho Song, Eunhye Park, Jingrui Wu, Juyeon Yoo, Jwa‐Min Nam   +6 more
wiley   +1 more source

Editorial: Structural studies of bacterial and viruses. [PDF]

Front Mol Biosci
Pastore A.
europepmc   +1 more source