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Kinetics of Allosteric Enzymes
Annual Review of Biophysics and Bioengineering, 1974Within the cell, hundreds of different chemical reactions go on simultaneously, each requiring different substrates and producing different products. This array of rea,ctions must be carefully regulated in order to maintain the orderly function of a cell.
G G, Hammes, C W, Wu
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Cathepsin C: An allosteric enzyme
Biochimica et Biophysica Acta (BBA) - Enzymology, 1970Abstract 1. 1. Cathepsin C requires Cl− for activity. Activation is also found with bromide, iodide, thiocyanate, nitrate, and chlorate. 2. 2. At saturating activator concentrations, substrates are split according to Michaelis-Menten kinetics; at non-saturating concentrations cooperativity is observed.
J, Gorter, M, Gruber
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Allosteric Regulation of Chromatin-Modifying Enzymes
Biochemistry, 2018Dynamic changes in chromatin structure are crucial for diverse biological processes. Given the complexity of the epigenetic landscape, understanding the specificity of chromatin modification has been a major interest in the epigenetics field. Recent progress in biochemical and structural analyses in the field of chromatin biology has revealed that ...
Jung-Ae Kim, Minjung Kwon, Jaehoon Kim
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1993
Abstract 8.1 Allostery 8.1.1 Basic tenets of allosteric behaviour The term allosteric (Greek, alios = other, steros = solid or space) is an ill-defined term used to describe the behaviour of numerous proteins.
Raymond C Stevens, William N Lipscomb
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Abstract 8.1 Allostery 8.1.1 Basic tenets of allosteric behaviour The term allosteric (Greek, alios = other, steros = solid or space) is an ill-defined term used to describe the behaviour of numerous proteins.
Raymond C Stevens, William N Lipscomb
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Choline kinase as an allosteric enzyme
Biochemical and Biophysical Research Communications, 1970Abstract Choline kinase, enriched over 1,000-fold from the filaments of Cuscuta reflexa Roxb. exhibited sigmoidal response in assays with subsaturating levels of choline. The major part of the enzymic activity in the tissue resided in particulate fractions sedimenting at low centrifugal fields.
P N, Setty, P S, Krishnan
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Searching for new allosteric sites in enzymes
Current Opinion in Structural Biology, 2004The discovery of new allosteric sites generates opportunities for the identification of novel pharmaceuticals and increases our understanding of basic biological processes. Increasingly, allosteric sites are being discovered in various families of proteins by several methods, paving the way for the development of entirely new classes of drugs with a ...
Jeanne A, Hardy, James A, Wells
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Molting fluid chitinase: A homotropic allosteric enzyme
Biochemical and Biophysical Research Communications, 1979Abstract The molting fluid of the tobacco hornworm has chitinase activity which shows allosteric behavior with chitin. A parabolic curve is obtained on a double reciprocal plot of 1 v vs. 1 [S] , and a sigmoid curve results when v (N-acetylglucosamine produced) is plotted against [S] (chitin concentration in terms of N-acetylglucosamine ...
M L, Bade, A, Stinson
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Active site directed effectors of allosteric enzymes
Biochimica et Biophysica Acta (BBA) - Enzymology, 1975This communication introduces the concept of an active site directed effector, in terms of the two state model of Monod et al. (Monod, J., Wyman, J. and Changeux, J.-P. (1965) J. Mol. Biol. 12, 88-118), a consideration made necessary by the observation that the activity of a number of enzymes of the control type is modulated by effector molecules whose
G D, Smith, D V, Roberts, P W, Kuchel
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Models for hemoglobin and allosteric enzymes
Biopolymers, 1968AbstractA model for hemoglobin is proposed and its application to allosteric enzymes is discussed with particular reference to asparate transcarbamylase. The main assumptions made are that the molecule is composed of subunits and that occupation of a sub‐unit produces a conformational change which affects the occupational probability of neighboring ...
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Amino acid biosynthesis: New architectures in allosteric enzymes
Plant Physiology and Biochemistry, 2008This review focuses on the allosteric controls in the Aspartate-derived and the branched-chain amino acid biosynthetic pathways examined both from kinetic and structural points of view. The objective is to show the differences that exist among the plant and microbial worlds concerning the allosteric regulation of these pathways and to unveil the ...
Curien, Gilles +5 more
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