Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou+8 more
wiley +1 more source
Isolation of Allosteric Tryptase Inhibitor from Methanol Extract of Rhubarb and Enhancement of Its Tryptase Inhibitory Activity by Compounds That Were Screened by In Silico Screening. [PDF]
Fujii H+7 more
europepmc +1 more source
Autonomous Artificial Molecular Motors and Pumps
Autonomous energy consumption is the only way to introduce molecular motors into more sophisticated, larger systems, capable of life‐like behavior. We reviewed a selection of the most recent advances in the field molecular motors focusing on those capable of performing continuous and autonomous motion under constant experimental conditions, that is ...
Chiara Taticchi+2 more
wiley +1 more source
Isoleucine Binding and Regulation of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> Threonine Dehydratase (IlvA). [PDF]
Yun MK+5 more
europepmc +1 more source
Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFEL
This review examines two decades of continuous development in macromolecular crystallography beamlines at the Swiss Light Source, along with recent contributions from SwissFEL, in the broader context of the evolution of macromolecular crystallography at synchrotron and X‐ray free‐electron laser facilities.This review highlights the development and ...
Meitian Wang
wiley +1 more source
Discovery of Novel Allosteric Inhibitor Hits for Insulin-Regulated Aminopeptidase Provides Insights on Enzymatic Mechanism. [PDF]
Georgaki G+5 more
europepmc +1 more source
Luteinizing hormone receptor knockout mouse: What has it taught us?
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley +1 more source
Exploring Aspartate Transcarbamoylase: A Promising Broad-Spectrum Target for Drug Development. [PDF]
Chen S+8 more
europepmc +1 more source