Results 271 to 280 of about 2,040,864 (360)

Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme

, 2018
Yijia Li, Li Du, Jiang‐Hai Wang, Ramir Vega, Terry D. Lee, Yunan Miao, Grace Aldana-Masangkay, Eric R. Samuels, Baozong Li, Xiaohu Ouyang, Sharon Colayco, Ekaterina V. Bobkova, Daniela Divlianska, Eduard Sergienko, Thomas D.Y. Chung, Marwan Fakih, Yuan Chen   +16 more
openalex   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Christian Bohr. Discoverer of Homotropic and Heterotopic Allostery: Periods Leading up to Bohr's Life, Work, and Beyond. Was Bohr a Vitalist and Right About a "Specific Activity"? [PDF]

Acta Physiol (Oxf)
Bindslev N.
europepmc   +1 more source

Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis

Brain Pathology, EarlyView.
We have sought to determine the role that cholesterol metabolism plays in disability worsening and its correlation with progressive MS by analysing patient CSF and post‐mortem tissues using cutting edge mass spectrometry approaches. Key sterol metabolites measured in the CSF link with important disability milestones at the very early stages of MS ...
Lauren Griffiths, Kristen Hawkins, Eylan Yutuc, Roberto Angelini, Racheal Fosuah, Manuela Pacciarini, Alison Dickson, Neil Robertson, Laura Childs, Samantha Loveless, Emma Tallantyre, William J. Griffiths, Yuqin Wang, Owain W. Howell   +13 more
wiley   +1 more source

Expression, purification, and characterization of pyruvate kinase from Mycobacterium tuberculosis: A key allosteric regulatory enzyme

, 2018
M. Hanumanthappa, Pavan Gollapali, Manjunath Chavdi, SJ Sudharshan   +3 more
openalex   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: an integrative in silico and <i>in-vitro</i> study. [PDF]

Front Oncol
Wang J, Yuan F, Kendre M, He Z, Dong S, Patil A, Padvi K.   +6 more
europepmc   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

'Intelligent' proteins. [PDF]

Cell Mol Life Sci
Tripathi T, Uversky VN, Giuliani A.
europepmc   +1 more source

Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer

, 2019
Nazimuddin Khan, Parag P. Shah, David Ban, Pablo Trigo‐Mouriño, Marta G. Carneiro, Lynn DeLeeuw, William L. Dean, John O. Trent, Levi J. Beverly, Manfred Konrad, Donghan Lee, T. Michael Sabo   +11 more
openalex   +1 more source