Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate [PDF]
, 2013 Cellular decision-making is driven by dynamic behaviours, such as the preparations for sunrise enabled by circadian rhythms and the choice of cell fates enabled by positive feedback.
Mac Gabhann, Feilim +2 more
core +13 more sources
The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function
Cell, 2014 Kamakshi Sureka +12 more
openalex +2 more sources
Statistical Mechanics of Allosteric Enzymes [PDF]
The Journal of Physical Chemistry B, 2016 The concept of allostery in which macromolecules switch between two different conformations is a central theme in biological processes ranging from gene regulation to cell signaling to enzymology. Allosteric enzymes pervade metabolic processes, yet a simple and unified treatment of the effects of allostery in enzymes has been lacking.
Einav, Tal +2 more
openaire +6 more sources
The contribution of two isozymes to the pyruvate kinase activity of Vibrio cholerae: One K+-dependent constitutively active and another K+-independent with essential allosteric activation. [PDF]
PLoS ONE, 2017 In a previous phylogenetic study of the family of pyruvate kinase EC (2.7.1.40), a cluster with Glu117 and another with Lys117 were found (numbered according to the rabbit muscle enzyme).
Carlos Guerrero-Mendiola +4 more
doaj +1 more source
Computational modeling of cAMP-dependent protein kinase allostery [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Allosteric regulation by ATP of peptide binding with a cAMP-dependent protein kinase catalytic subunit was comÂputationally modeled by combining conventional docking analysis and molecular dynamics calculations.
Andrei Izvolski, Aleksei Kuznetsov
doaj +1 more source
Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity
eLife, 2020 Engineered allosteric regulation of protein activity provides significant advantages for the development of robust and broadly applicable tools. However, the application of allosteric switches in optogenetics has been scarce and suffers from critical ...
M. Shaaya +14 more
semanticscholar +1 more source
ATP-Dependent Allosteric DNA Enzymes [PDF]
Chemistry & Biology, 2002 Effector-activated ribozymes that respond to small organic molecules have previously been generated by appending binding species (aptamers) to ribozymes. In order to determine if deoxyribozymes can similarly be activated by effector molecules, we have appended an anti-adenosine aptamer to a selected deoxyribozyme ligase.
Andrew D. Ellington, Matthew Levy
openaire +3 more sources
Frontiers in Molecular Biosciences, 2023 Mesophilic and thermophilic enzyme counterparts are often studied to understand how proteins function under harsh conditions. To function well outside of standard temperature ranges, thermophiles often tightly regulate their structural ensemble through ...
Alexa L. Knight +2 more
doaj +1 more source
Crystallographic exploration of flexibility in an allosteric enzyme [PDF]
Acta Crystallographica Section A Foundations and Advances, 2018 David J. Schuller +2 more
openalex +2 more sources
Rational engineering of enzyme allosteric regulation through sequence evolution analysis.
PLoS Computational Biology, 2012 Control of enzyme allosteric regulation is required to drive metabolic flux toward desired levels. Although the three-dimensional (3D) structures of many enzyme-ligand complexes are available, it is still difficult to rationally engineer an ...
Jae-Seong Yang +4 more
doaj +1 more source