Results 31 to 40 of about 1,971,711 (246)
Molecules, 2023 Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered ...
Alexander Zhuravlev +7 more
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PLoS ONE, 2021 Dengue virus (DENV) encodes a unique protease (NS3/NS2B) essential for its maturation and infectivity and, it has become a key target for anti-viral drug design to treat dengue and other flavivirus related infections.
R V Sriram Uday +7 more
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Frontiers in Molecular Biosciences, 2018 The enzyme imidazole glycerol phosphate synthase (IGPS) is a model for studies of long-range allosteric regulation in enzymes. Binding of the allosteric effector ligand N'-[5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide-ribonucleotide ...
George P. Lisi +3 more
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Information propagation in time through allosteric signaling [PDF]
Phys. Rev. Research 2, 023367 (2020), 2019 Naively, one expects the information communicated by an enzyme downstream within a signaling network, in which the enzyme is embedded, to grow monotonically with the enzyme's rate of product formation. However, here we observe that this does not necessarily hold true for allosterically regulated enzymes, often observed in signaling networks.
arxiv +1 more source
Mammalian Alkaline Phosphatases Are Allosteric Enzymes [PDF]
Journal of Biological Chemistry, 1997 Mammalian alkaline phosphatases (APs) are zinc-containing metalloenzymes encoded by a multigene family and functional as dimeric molecules. Using human placental AP (PLAP) as a paradigm, we have investigated whether the monomers in a given PLAP dimer are subject to cooperativity during catalysis following an allosteric model or act via a half-of-sites ...
Thomas Manes +5 more
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Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using ᴅ-Amino Acids. [PDF]
PLoS ONE, 2016 Chirality plays a major role in recognition and interaction of biologically important molecules. The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) is the first enzyme of the shikimate pathway, which is responsible for the synthesis
Sebastian Reichau +3 more
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Allosteric regulation of epigenetic modifying enzymes [PDF]
Current Opinion in Chemical Biology, 2017 Epigenetic enzymes including histone modifying enzymes are key regulators of gene expression in normal and disease processes. Many drug development strategies to target histone modifying enzymes have focused on ligands that bind to enzyme active sites, but allosteric pockets offer potentially attractive opportunities for therapeutic development. Recent
Philip A. Cole, Beth E. Zucconi
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Exploring Allosteric Pathways of a V-Type Enzyme with Dynamical Perturbation Networks.
Journal of Physical Chemistry B, 2019 Elucidation of the allosteric pathways in proteins is a computational challenge that strongly benefits from combination of atomistic molecular dynamics (MD) simulations and coarse-grained analysis of the complex dynamical network of chemical interactions
Aria Gheeraert +5 more
semanticscholar +1 more source
Engineering in Life Sciences, 2021 Conformational change associated with allosteric regulation in a protein is ultimately driven by energy transformation. However, little is known about the latter process.
Shizhen Wang +2 more
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Link between allosteric signal transduction and functional dynamics in a multi-subunit enzyme: S-adenosylhomocysteine hydrolase [PDF]
J. Am. Chem. Soc. (2011) vol. 133, 19807-19815, 2011 S-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important drug target in the discovery of antiviral agents. While targeting the active site is a straightforward strategy of enzyme inhibition, evidences of allosteric modulation of ...
arxiv +1 more source