Results 41 to 50 of about 1,971,711 (246)
PLoS ONE, 2014 Targeting allosteric sites is gaining increasing recognition as a strategy for modulating the activity of enzymes, especially in drug design. Here we investigate the mechanisms of allosteric regulation of cathepsin K as a representative of cysteine ...
Marko Novinec +2 more
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Multiple conformations in solution of the maize C4-phosphoenolpyruvate carboxylase isozyme
Heliyon, 2021 The photosynthetic phosphoenolpyruvate carboxylase isozyme from C4 plants (PEPC-C4) has a complex allosteric regulation, involving positive cooperativity in binding the substrate phosphoenolpyruvate as well as positive and negative allosteric effectors ...
Fátima Barreda-Huerta +3 more
doaj
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
Nature Communications, 2018 E1 enzymes activate ubiquitin (Ub) and ubiquitin-like modifiers (Ubls) in the first step of Ub/Ubl conjugation cascades and represent potential targets for therapeutic intervention in cancer and other life-threatening diseases.
Z. Lv +9 more
semanticscholar +1 more source
PLoS ONE, 2014 The role of tertiary conformational changes associated to ligand binding was explored using the allosteric enzyme glucosamine-6-phosphate (GlcN6P) deaminase from Escherichia coli (EcGNPDA) as an experimental model.
Sergio Zonszein +3 more
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Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria. [PDF]
PLoS Computational Biology, 2013 Pyruvate kinase (PYK) is a critical allosterically regulated enzyme that links glycolysis, the primary energy metabolism, to cellular metabolism. Lactic acid bacteria rely almost exclusively on glycolysis for their energy production under anaerobic ...
Nadine Veith +5 more
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Understanding allosteric and cooperative interactions in enzymes [PDF]
The FEBS Journal, 2013 The paper that introduced biochemists to the idea of allosteric feedback inhibition [Monod J, Changeux J‐P & Jacob F (1963) J Mol Biol 6, 306–329] is now 50 years old, and the two papers on models for enzyme cooperativity that followed it [Monod J, Wyman J & Changeux J‐P (1965) J Mol Biol 12, 88–118; Koshland DE, Némethy G & Filmer D (1966)
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Journal of Biological Chemistry, 2016 Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some ...
Kyle W. Anderson +5 more
semanticscholar +1 more source
Frontiers in Molecular Biosciences, 2022 5-Aminolevulinate synthase (ALAS; E.C. 2.3.1.37) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the key regulatory step of porphyrin biosynthesis in metazoa, fungi, and α-proteobacteria.
Gregory A. Hunter +3 more
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Allosteric enzymes as biosensors for molecular diagnosis [PDF]
FEBS Letters, 2003 Biosensors are hybrid analytical devices that amplify signals generated from the specific interaction between a receptor and the analyte, through a biochemical mechanism. Biosensors use tissues, whole cells, artificial membranes or cell components like proteins or nucleic acids as receptors, coupled to a physicochemical signal transducer.
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Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.
Angewandte Chemie, 2016 Conjugation of the small ubiquitin-like modifier (SUMO) to protein substrates is an important disease-associated posttranslational modification, although few inhibitors of this process are known.
W. M. Hewitt +12 more
semanticscholar +1 more source