Results 41 to 50 of about 2,040,864 (360)
Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using ᴅ-Amino Acids. [PDF]
PLoS ONE, 2016 Chirality plays a major role in recognition and interaction of biologically important molecules. The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) is the first enzyme of the shikimate pathway, which is responsible for the synthesis
Sebastian Reichau +3 more
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Exploring Allosteric Pathways of a V-Type Enzyme with Dynamical Perturbation Networks.
Journal of Physical Chemistry B, 2019 Elucidation of the allosteric pathways in proteins is a computational challenge that strongly benefits from combination of atomistic molecular dynamics (MD) simulations and coarse-grained analysis of the complex dynamical network of chemical interactions
Aria Gheeraert +5 more
semanticscholar +1 more source
Allosteric regulation of epigenetic modifying enzymes [PDF]
Current Opinion in Chemical Biology, 2017 Epigenetic enzymes including histone modifying enzymes are key regulators of gene expression in normal and disease processes. Many drug development strategies to target histone modifying enzymes have focused on ligands that bind to enzyme active sites, but allosteric pockets offer potentially attractive opportunities for therapeutic development. Recent
Philip A. Cole, Beth E. Zucconi
openaire +3 more sources
PLoS ONE, 2014 Targeting allosteric sites is gaining increasing recognition as a strategy for modulating the activity of enzymes, especially in drug design. Here we investigate the mechanisms of allosteric regulation of cathepsin K as a representative of cysteine ...
Marko Novinec +2 more
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Engineering in Life Sciences, 2021 Conformational change associated with allosteric regulation in a protein is ultimately driven by energy transformation. However, little is known about the latter process.
Shizhen Wang +2 more
doaj +1 more source
Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002 [PDF]
, 2016 The phosphatidylinositide 3-kinases (PI3K) and mammalian target of rapamycin-1 (mTOR1) are two key targets for anti-cancer therapy. Predicting the response of the PI3K/AKT/mTOR1 signalling pathway to targeted therapy is made difficult because of network ...
Bown, James L. +4 more
core +3 more sources
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
Nature Communications, 2018 E1 enzymes activate ubiquitin (Ub) and ubiquitin-like modifiers (Ubls) in the first step of Ub/Ubl conjugation cascades and represent potential targets for therapeutic intervention in cancer and other life-threatening diseases.
Z. Lv +9 more
semanticscholar +1 more source
Multiple conformations in solution of the maize C4-phosphoenolpyruvate carboxylase isozyme
Heliyon, 2021 The photosynthetic phosphoenolpyruvate carboxylase isozyme from C4 plants (PEPC-C4) has a complex allosteric regulation, involving positive cooperativity in binding the substrate phosphoenolpyruvate as well as positive and negative allosteric effectors ...
Fátima Barreda-Huerta +3 more
doaj
Journal of Biological Chemistry, 2018 Altered glycolytic flux in cancer cells (the “Warburg effect”) causes their proliferation to rely upon elevated glutamine metabolism (“glutamine addiction”).
Qingqiu Huang +8 more
semanticscholar +1 more source
PLoS ONE, 2014 The role of tertiary conformational changes associated to ligand binding was explored using the allosteric enzyme glucosamine-6-phosphate (GlcN6P) deaminase from Escherichia coli (EcGNPDA) as an experimental model.
Sergio Zonszein +3 more
doaj +1 more source