Results 51 to 60 of about 2,040,864 (360)
Allosteric enzymes as biosensors for molecular diagnosis [PDF]
FEBS Letters, 2003 Biosensors are hybrid analytical devices that amplify signals generated from the specific interaction between a receptor and the analyte, through a biochemical mechanism. Biosensors use tissues, whole cells, artificial membranes or cell components like proteins or nucleic acids as receptors, coupled to a physicochemical signal transducer.
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Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. [PDF]
, 2016 This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function.
Chang, Chia-En A +3 more
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Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria. [PDF]
PLoS Computational Biology, 2013 Pyruvate kinase (PYK) is a critical allosterically regulated enzyme that links glycolysis, the primary energy metabolism, to cellular metabolism. Lactic acid bacteria rely almost exclusively on glycolysis for their energy production under anaerobic ...
Nadine Veith +5 more
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Journal of Biological Chemistry, 2016 Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some ...
Kyle W. Anderson +5 more
semanticscholar +1 more source
Understanding allosteric and cooperative interactions in enzymes [PDF]
The FEBS Journal, 2013 The paper that introduced biochemists to the idea of allosteric feedback inhibition [Monod J, Changeux J‐P & Jacob F (1963) J Mol Biol 6, 306–329] is now 50 years old, and the two papers on models for enzyme cooperativity that followed it [Monod J, Wyman J & Changeux J‐P (1965) J Mol Biol 12, 88–118; Koshland DE, Némethy G & Filmer D (1966)
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Structure of rabbit liver fructose 1,6-bisphosphatase at 2.3 Å resolution [PDF]
, 1999 The three-dimensional structure of the R form of rabbit liver fructose 1,6-bisphosphatase (Fru-1,6-Pase; E.C. 3.1.3.11) has been determined by a combination of heavy-atom and molecular-replacement methods.
Erman, M. +5 more
core +2 more sources
Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
Cell Discovery, 2020 Human NAD-dependent isocitrate dehydrogenase or HsIDH3 catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. HsIDH3 exists and functions as a heterooctamer composed of the αβ and αγ heterodimers, and is regulated ...
Pengkai Sun +3 more
doaj +1 more source
Biochemical Journal, 2015 We have studied enzyme kinetics, nucleotide binding and allosteric modulation of six recombinant AMP-activated protein kinase (AMPK) isoforms by known allosteric activators.
F. Rajamohan +11 more
semanticscholar +1 more source
Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]
, 2012 Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair +2 more
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Frontiers in Molecular Biosciences, 2022 5-Aminolevulinate synthase (ALAS; E.C. 2.3.1.37) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the key regulatory step of porphyrin biosynthesis in metazoa, fungi, and α-proteobacteria.
Gregory A. Hunter +3 more
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