Results 61 to 70 of about 1,971,711 (246)

The rice endosperm ADP-glucose pyrophosphorylase large subunit is essential for optimal catalysis and allosteric regulation of the heterotetrameric enzyme.

Plant and Cell Physiology, 2014
Although an alternative pathway has been suggested, the prevailing view is that starch synthesis in cereal endosperm is controlled by the activity of the cytosolic isoform of ADPglucose pyrophosphorylase (AGPase). In rice, the cytosolic AGPase isoform is
Aytug Tuncel, J. Kawaguchi, Yasuharu Ihara, Hiroaki Matsusaka, A. Nishi, Tetsuhiro Nakamura, S. Kuhara, H. Hirakawa, Yasunori Nakamura, B. Cakir, Ai Nagamine, T. Okita, Seon-Kap Hwang, H. Satoh   +13 more
semanticscholar   +1 more source

Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2017
The first enzyme of the shikimate pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS), adopts a range of distinct allosteric regulation mechanisms in different organisms, related to different quaternary assemblies.
Wanting Jiao, Nicola J Blackmore, Ali Reza Nazmi, Emily J Parker   +3 more
doaj   +1 more source

Eigenvector Centrality Distribution for Characterization of Protein Allosteric Pathways [PDF]

, 2017
Determining the principal energy pathways for allosteric communication in biomolecules, that occur as a result of thermal motion, remains challenging due to the intrinsic complexity of the systems involved. Graph theory provides an approach for making sense of such complexity, where allosteric proteins can be represented as networks of amino acids.
arxiv   +1 more source

Michaelis-Menten at 100 and allosterism at 50: driving molecular motors in a hailstorm with noisy ATPase engines and allosteric transmission [PDF]

FEBS J. (Federation of European Biochem. Soc.), Special Issue: Enzyme Catalysis and Allostery: A Century of Advances in Molecular Understanding, vol.281, 601-611(2014), 2017
Cytoskeletal motor proteins move on filamentous tracks by converting input chemical energy that they derive by catalyzing the hydrolysis of ATP. The ATPase site is the analog of an engine and hydrolysis of ATP is the analog of burning of chemical fuel.
arxiv   +1 more source

Structural identification of the pathway of long-range communication in an allosteric enzyme

Proceedings of the National Academy of Sciences of the United States of America, 2008
Allostery is a common mechanism of regulation of enzyme activity and specificity, and its signatures are readily identified from functional studies. For many allosteric systems, structural evidence exists of long-range communication among protein domains,
Prafull S Gandhi, Zhiwei Chen, F. Mathews, E. Di Cera   +3 more
semanticscholar   +1 more source

Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition

Molecules, 2021
The COVID-19 pandemic has caused millions of fatalities since 2019. Despite the availability of vaccines for this disease, new strains are causing rapid ailment and are a continuous threat to vaccine efficacy.
Shah Faisal, Syed Lal Badshah, Bibi Kubra, Mohamed Sharaf, Abdul-Hamid Emwas, Mariusz Jaremko, Mohnad Abdalla   +6 more
doaj   +1 more source

Novel allosteric inhibition of phosphoribulokinase identified by ensemble kinetic modeling of Synechocystis sp. PCC 6803 metabolism

Metabolic Engineering Communications, 2020
The present study attempted a computer simulation of the metabolism of a model cyanobacteria, Synechocystis sp. PCC 6803 (PCC 6803) to predict allosteric inhibitions that are likely to occur in photoautotrophic and mixotrophic conditions as well as in a ...
Hiroki Nishiguchi, James Liao, Hiroshi Shimizu, Fumio Matsuda   +3 more
doaj  

Discovery of intramolecular signal transduction network based on a new protein dynamics model of energy dissipation. [PDF]

PLoS ONE, 2012
A novel approach to reveal intramolecular signal transduction network is proposed in this work. To this end, a new algorithm of network construction is developed, which is based on a new protein dynamics model of energy dissipation. A key feature of this
Cheng-Wei Ma, Zhi-Long Xiu, An-Ping Zeng
doaj   +1 more source

Transition in relaxation paths in allosteric molecules: enzymatic kinetically constrained model [PDF]

Phys. Rev. Research 2, 012005 (2020), 2018
A hierarchy of timescales is ubiquitous in biological systems, where enzymatic reactions play an important role because they can hasten the relaxation to equilibrium. We introduced a statistical physics model of interacting spins that also incorporates enzymatic reactions to extend the classic model for allosteric regulation.
arxiv   +1 more source

Conversion of Non-allosteric Pyruvate Kinase Isozyme into an Allosteric Enzyme by a Single Amino Acid Substitution*

Journal of Biological Chemistry, 1997
Pyruvate kinase M1, a non-allosteric isozyme, was converted into an allosteric enzyme by replacement of an amino acid in the intersubunit contact. The substitution of Ala-398 with Arg resulted in the pronounced allosteric enzyme. The Hill coefficient and
Yoshitaka Ikeda, Takehiko Tanaka, T. Noguchi   +2 more
semanticscholar   +1 more source