Results 71 to 80 of about 1,971,711 (246)
Identification of the allosteric regulatory site of insulysin. [PDF]
PLoS ONE, 2011 Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and
Nicholas Noinaj +7 more
doaj +1 more source
Enzyme Inhibition by Allosteric Capture of an Inactive Conformation [PDF]
Journal of Molecular Biology, 2011 All members of the human herpesvirus protease (HHV Pr) family are active as weakly associating dimers but inactive as monomers. A small-molecule allosteric inhibitor of Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr) traps the enzyme in an inactive monomeric state where the C-terminal helices are unfolded and the hydrophobic dimer interface ...
Gregory M. Lee +4 more
openaire +3 more sources
The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM
Current Research in Structural Biology, 2020 Glycogen and starch are the major carbon and energy reserve polysaccharides in nature, providing living organisms with a survival advantage. The evolution of the enzymatic machinery responsible for the biosynthesis and degradation of such polysaccharides,
Javier O. Cifuente +6 more
doaj
Bioinformatic Scaling of Allosteric Interactions in Biomedical Isozymes [PDF]
, 2015 Allosteric (long-range) interactions can be surprisingly strong in proteins of biomedical interest. Here we use bioinformatic scaling to connect prior results on nonsteroidal anti-inflammatory drugs to promising new drugs that inhibit cancer cell metabolism.
arxiv +1 more source
Drug Design, Development and Therapy, 2022 Lara Alzyoud,1 Mohammad A Ghattas,1,2 Noor Atatreh1,2 1College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates; 2AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab EmiratesCorrespondence: Mohammad A ...
Alzyoud L, Ghattas MA, Atatreh N
doaj
Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase
Nature CommunicationsAllosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulation in bacteria
Ondřej Bulvas +8 more
doaj +1 more source
Notes on stochastic (bio)-logic gates: the role of allosteric cooperativity [PDF]
, 2014 Recent experimental breakthroughs have finally allowed to implement in-vitro reaction kinetics (the so called {\em enzyme based logic}) which code for two-inputs logic gates and mimic the stochastic AND (and NAND) as well as the stochastic OR (and NOR). This accomplishment, together with the already-known single-input gates (performing as YES and NOT),
arxiv +1 more source
Fractal mechanisms for the allosteric effects of proteins and enzymes
Biophysical Journal, 1990 Investigations have been made on the reaction kinetics of proteins and enzymes by the statistical methods of random walks on fractal structures. From the point of view of networks of Trap (R) and Free (T) sites, the relationships between the Hill coefficients (h) and the fractal (df) as well as spectral (ds) dimensions of protein molecules are obtained.
Houqiang Li, Haming Zhao, Shuhua Chen
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PCR-like cascade reactions in the context of an allosteric enzyme mimic.
Journal of the American Chemical Society, 2008 A supramolecular allosteric catalyst that exhibits a PCR-like cascade reaction is reported. The complex is triggered by a reaction with an acetate ion, which turns on a catalytic cascade that exponentially increases acetate ion concentration through an ...
H. Yoon, C. Mirkin
semanticscholar +1 more source
CrystalsPyruvate kinase (PK) deficiency is a rare genetic disorder that affects this critical enzyme within the glycolysis pathway. In recent years, Mitapivat (MTPV, AG-348) has emerged as a notable allosteric activator for treating PK deficiency.
Xiao Han +5 more
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