Results 81 to 90 of about 1,971,711 (246)
Ca2+ binding induced sequential allosteric activation of sortase A: An example for ion-triggered conformational selection. [PDF]
PLoS ONE, 2018 The allosteric activation of the intrinsically disordered enzyme Staphylococcus aureus sortase A is initiated via binding of a Ca2+ ion. Although Ca2+ binding was shown to initiate structural changes inducing disorder-to-order transitions, the details of
Ilke Ugur +5 more
doaj +1 more source
Mapping active allosteric loci SARS-CoV Spike Proteins by means of Protein Contact Networks [PDF]
arXiv, 2020 Coronaviruses are a class of virus responsible of the recent outbreak of Human Severe Acute Respiratory Syndrome. The molecular machinery behind the viral entry and thus infectivity is based on the formation of the complex of virus spike protein with the angiotensin-converting enzyme 2 (ACE2).
arxiv
Thresholds, long delays and stability from generalized allosteric effect in protein networks [PDF]
, 2006 Post-transductional modifications tune the functions of proteins and regulate the collective dynamics of biochemical networks that determine how cells respond to environmental signals. For example, protein phosphorylation and nitrosylation are well-known to play a pivotal role in the intracellular transduction of activation and death signals. A protein
arxiv +1 more source
Substrates modulate charge-reorganization allosteric effects in protein-protein association [PDF]
arXiv, 2021 Protein function may be modulated by an event occurring far away from the functional site, a phenomenon termed allostery. While classically allostery involves conformational changes, we recently observed that charge redistribution within an antibody can also lead to an allosteric effect, modulating the kinetics of binding to target antigen.
arxiv
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Allosteric sites on proteins are targeted for designing more selective inhibitors of enzyme activity and to discover new functions. Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a ...
Carlos Roca +9 more
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The leucyl aminopeptidase from Helicobacter pylori is an allosteric enzyme.
Microbiology, 2005 This study describes the cloning, genetic analysis and biochemical characterization of a leucyl aminopeptidase (LAP) from Helicobacter pylori. A gene encoding LAP was cloned from H.
Lei Dong +5 more
semanticscholar +1 more source
Biochemical Journal, 1976 The steady-state equations for "random" enzymic mechanisms (ones with alternative routes for substrate and enzyme to form enzyme-substrate complexes) are non-Michaelian and very complicated when a quasi-equilibrium approximation cannot be used.
E. Whitehead
semanticscholar +1 more source
Conformational Control of Mechanical Networks [PDF]
, 2018 Understanding conformational change is crucial for programming and controlling the function of many mechanical systems such as allosteric enzymes and tunable metamaterials. Of particular interest is the relationship between the network topology or geometry and the specific motions observed under controlling perturbations.
arxiv +1 more source
A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 The discovery of allosteric modulators is a multi-disciplinary approach, which is time- and cost-intensive. High-throughput screening combined with novel computational tools can reduce these factors. Thus, we developed an enzyme activity assay, which can
Ariane Menden +7 more
doaj +1 more source
Scientific Reports, 2023 There is growing recognition that the functional outcome of binding of an allosteric regulator to a protein/enzyme is influenced by the presence of other ligands.
Tyler A. Martin, Aron W. Fenton
doaj +1 more source