Results 41 to 50 of about 1,267 (159)

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase

Viruses, 2022
Reverse transcriptase (RT) and integrase (IN) are encoded tandemly in the pol genes of retroviruses. We reported recently that HIV-1 RT and IN need to be supplied as the pol precursor intermediates, in which RT and IN are in fusion form (RTIN) to exert ...
Takao Masuda, Osamu Kotani, Masaru Yokoyama, Yuya Abe, Gota Kawai, Hironori Sato   +5 more
doaj   +1 more source

Strategies in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

Viruses, 2023
AIDS (acquired immunodeficiency syndrome) is a potentially life-threatening infectious disease caused by human immunodeficiency virus (HIV). To date, thousands of people have lost their lives annually due to HIV infection, and it continues to be a big ...
Murugesan Vanangamudi, Senthilkumar Palaniappan, Muthu Kumaradoss Kathiravan, Vigneshwaran Namasivayam   +3 more
doaj   +1 more source

Everything OLD is new again: How structural, functional, and bioinformatic advances have redefined a neglected nuclease family

Molecular Microbiology, Volume 120, Issue 2, Page 122-140, August 2023., 2023
OLD family nucleases are conserved ATP‐powered enzymes that function broadly in anti‐phage defense. In this review, we summarize our current understanding of OLD structure, function, and evolution, highlighting important advances gleaned from bioinformatics, genetics, and X‐ray crystallography.
Elena Wanvig Dot, Lynn C. Thomason, Joshua S. Chappie   +2 more
wiley   +1 more source

Chemical and Biological Strategies for Profiling Protein‐Protein Interactions in Living Cells

Chemistry – An Asian Journal, Volume 18, Issue 14, July 17, 2023., 2023
The ability to explicate the complicated protein‐protein interactions (PPIs) network can greatly advance the understanding of the mechanisms underlying virtually all the cellular events. This review summarizes the chemical and biological strategies developed to monitor, analyze and identify the PPIs in living cells with highlights on their limitations ...
You‐Yu Wang, Wenyi Li, Bang‐Ce Ye, Xiao‐Bao Bi   +3 more
wiley   +1 more source

HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio

Retrovirology, 2021
Background During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice.
Shuohui Liu, Pratibha C. Koneru, Wen Li, Chathuri Pathirage, Alan N. Engelman, Mamuka Kvaratskhelia, Karin Musier-Forsyth   +6 more
doaj   +1 more source

Molecular Computation for Molecular Classification

Advanced Biology, Volume 7, Issue 3, March 2023., 2023
DNA has emerged as a formidable medium for performing molecular computation. One promising direction is the use of molecular computers for sample classification and pattern recognition, which is of particular interest for diagnostic applications. In this survey, the recent demonstrations of classification tasks performed by molecular circuits are ...
Coline Kieffer, Anthony J. Genot, Yannick Rondelez, Guillaume Gines   +3 more
wiley   +1 more source

Influence of the amino-terminal sequence on the structure and function of HIV integrase

Retrovirology, 2020
Background Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by the human immunodeficiency virus (HIV). Successful development of ART can be accelerated by accurate structural and biochemical data on targets and their responses
Grant Eilers, Kushol Gupta, Audrey Allen, Jeffrey Zhou, Young Hwang, Michael B. Cory, Frederic D. Bushman, Gregory Van Duyne   +7 more
doaj   +1 more source

Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV‐1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole Derivatives, and in Silico Anti‐HIV‐1 Studies

Bioinorganic Chemistry and Applications, Volume 2023, Issue 1, 2023., 2023
In this paper, the novel Schiff base ligand containing quinoline moiety and its novel copper chelate complexes were successfully prepared. The catalytic activity of the final complex in the organic reaction such as synthesis of chiral benzimidazoles and anti‐HIV‐1 activity of Schiff base ligand and the products of this reaction were investigated.
Sabikeh G. Azimi, Ghodsieh Bagherzade, Mohammad Reza Saberi, Zeinab Amiri Tehranizadeh, Jamal Rafique   +4 more
wiley   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

A new class of multimerization selective inhibitors of HIV-1 integrase. [PDF]

PLoS Pathogens, 2014
The quinoline-based allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are promising candidates for clinically useful antiviral agents. Studies using these compounds have highlighted the role of IN in both early and late stages of virus replication ...
Amit Sharma, Alison Slaughter, Nivedita Jena, Lei Feng, Jacques J Kessl, Hind J Fadel, Nirav Malani, Frances Male, Li Wu, Eric Poeschla, Frederic D Bushman, James R Fuchs, Mamuka Kvaratskhelia   +12 more
doaj   +1 more source