Results 101 to 110 of about 36,012 (161)

Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69. [PDF]

PLoS Pathog
McHugh M, Njeshi CN, Smith N, Kashyap SS, Datta R, Sun H, Robertson AP, Martin RJ.   +7 more
europepmc   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed. [PDF]

FEBS J
Benjamin-Zukerman T, Pane V, Safadi-Safa R, Solomon M, Lev-Ram V, Aboraya M, Dakwar A, Bertinetti D, Hoy A, Mol MO, van Swieten J, Maillard R, Herberg FW, Ilouz R.   +13 more
europepmc   +1 more source

Allosteric modulation of NF1 GAP: Differential distributions of catalytically competent populations in loss-of-function and gain-of-function mutants. [PDF]

Protein Sci
Xu L, Jang H, Nussinov R.
europepmc   +1 more source

Meaty Aroma Compounds Enhance MSG Umami Perception Through Allosteric Modulation of T1R1/T1R3 Receptor: Evidence from Nasal Clip Sensory Evaluation and Molecular Dynamics Simulation. [PDF]

Foods
Zhao Y, Zhang J, Zhao M, Zhao X, Su G.
europepmc   +1 more source

mGlu4R, mGlu7R, and mGlu8R allosteric modulation for treating acute and chronic neurodegenerative disorders. [PDF]

Pharmacol Rep
Domin H, Burnat G.
europepmc   +1 more source

Allosteric modulation of the Lon protease via ssDNA binding and local charge changes. [PDF]

J Biol Chem
Ogdahl JL, Chien P.
europepmc   +1 more source

Positive allosteric modulation of AMPA receptors via PF4778574 leads to reduced demyelination and clinical disability in experimental models of multiple sclerosis. [PDF]

Front Immunol
Sindi M, Dietrich M, Klees D, Gruchot J, Hecker C, Silbereis J, Issberner A, Hartung HP, Ruck T, Stark H, Kurz T, Küry P, Meuth SG, Albrecht P.   +13 more
europepmc   +1 more source

Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization. [PDF]

Nat Commun
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Arefin A, Huynh K, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J.   +14 more
europepmc   +1 more source

SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. [PDF]

Proc Natl Acad Sci U S A
Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S.   +14 more
europepmc   +1 more source

Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation. [PDF]

Cell
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE.   +8 more
europepmc   +1 more source