Results 231 to 240 of about 702,558 (291)

Long-Range Allosteric Modulation of DNA Duplex Dynamics Induced by Pyrrole-Imidazole Polyamide Binding. [PDF]

J Phys Chem Lett
Kendall-Price SET, Nichol RJO, Taladriz-Sender A, Phelps R, Malakar P, Greetham GM, Burley GA, Hunt NT.   +7 more
europepmc   +1 more source

Evolution of the SARS‐CoV‐2 Main Protease Under Fitness Constraints Imposed by Folding Stability and Activity

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to evolve and diversify, leading to the emergence of immune‐evasive variants and underscoring the need for complementary antiviral strategies targeting conserved viral machinery. In this context, the main protease (Mpro) represents a potential therapeutic target because
David Ferreiro, Miguel Arenas
wiley   +1 more source

Unraveling GPCRs Allosteric Modulation. Cannabinoid 1 Receptor as a Case Study. [PDF]

Proteins
Cruz A, Warshel A.
europepmc   +1 more source

Rapid evolution and genetic basis of spinetoram resistance in Phthorimaea absoluta: evidence from six years of monitoring and laboratory selection

Pest Management Science, EarlyView.
Resistance to spinetoram in Phthorimaea absoluta is rapidly selected and functionally recessive at field‐relevant concentrations. Metabolic detoxification contributes partially, while cross‐resistance to spinosad and increased susceptibility to diamides and isoxazolines highlight practical options for resistance monitoring and insecticide rotation ...
Teófilo P. Langa, Vitor Quintela, Marcos de Oliveira, Herbert A. A. Siqueira   +3 more
wiley   +1 more source

Clove Essential Oil as an Antifungal Agent and Putative Dual-Action Antifungal Mechanism: Experimental Validation and Computational Insights into Orthosteric and Allosteric Modulation of Chitin Synthase I in <i>Penicillium</i> Species. [PDF]

Molecules
Castillo Y, Márquez Brazón EA, Peralta-Ruiz Y, Chaves-López C, Saurith-Coronell O, Grande-Tovar CD.   +5 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Allosteric modulation of Plasmodium falciparum Isoleucyl tRNA synthetase by South African natural compounds. [PDF]

PLoS One
Chepsiror C, Veldman W, Olotu F, Tastan Bishop Ö.   +3 more
europepmc   +1 more source

Structural basis for allosteric modulation of M. tuberculosis proteasome core particle. [PDF]

Nat Commun
Turner M, Uday AB, Velyvis A, Rennella E, Zeytuni N, Vahidi S.   +5 more
europepmc   +1 more source

GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and behavioral abnormalities in <i>Mecp2</i> and <i>Disc1</i> transgenic mice. [PDF]

Sci Adv
Ge Y, Tian T, Li B, Axerio-Cillies P, Chen W, Qin X, Zhao M, Sun QC, Li J, Floresco SB, Liu L, Yang X, Wang YT.   +12 more
europepmc   +1 more source