Allosteric modulation - Open Access .click

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Allosteric Modulators of the A1 Adenosine receptor

2008
The present invention provides compounds active as allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor, such as treatment of pain, in particular chronic pain such as neurophatic pain or cardiac disease.
BARALDI, Pier Giovanni, Moorman A. R., ROMAGNOLI, Romeo +2 more
openaire +2 more sources

Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold

Bioorganic and Medicinal Chemistry Letters, 2008
Alice L Rodríguez, P Jeffrey Conn, Craig W Lindsley +2 more
exaly

Allosteric modulation of G-protein coupled receptors

European Journal of Pharmaceutical Sciences, 2004
Anders A Jensen, Tracy A Spalding
exaly

Widespread Changes in Positive Allosteric Modulation of the Muscarinic M1 Receptor in Some Participants With Schizophrenia

International Journal of Neuropsychopharmacology, 2019
Shaun Hopper, Andrea Gogos, Brian Dean +2 more
exaly

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

Neuron, 2017
Daniel J Foster, P Jeffrey Conn
exaly

Allosteric modulation of G protein-coupled receptors

Il Farmaco, 2001
Adriaan P Ijzerman, Angeliki P Kourounakis +1 more
exaly

Allosteric modulation of nicotinic acetylcholine receptors

Biochemical Pharmacology, 2015
Neil S Millar
exaly