Results 241 to 250 of about 702,558 (291)

Negative Allosteric Modulation of Agonist-Induced M₂ Muscarinic Receptor/β-Arrestin Interaction by Serum Autoantibodies from Patients with Chronic Chagas Disease. [PDF]

Cells
Carrera Páez LC, Beltrame SP, Auger SR, Sabra AH, Bilder CR, Irurzun IM, Waldner CI, Goin JC.   +7 more
europepmc   +1 more source

Conformational diversity in class C GPCR positive allosteric modulation. [PDF]

Nat Commun
Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G.   +11 more
europepmc   +1 more source

Preferential allosteric modulation of Otop1 channels by small molecule compounds. [PDF]

Commun Biol
Kong X, Sun J, Zhang H, Yin Y, Liang X, Chen Y, Luo G, Xia H, Wang Y, Liu Z, Tang C.   +10 more
europepmc   +1 more source

Correction for Mittal et al., Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A). [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

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Olfaction: Allosteric modulation

Current Biology, 2023
New research indicates that the odor-evoked responses of human olfactory receptors can be enhanced via the non-competitive binding of an allosteric modulator. This modulatory mechanism adds an additional layer of complexity to the peripheral encoding of odors.
Samuel, Caton, Adam, Dewan
openaire   +2 more sources

Allosteric modulation of caspases

Pharmacology & Therapeutics, 2011
Caspases are proteolytic enzymes mainly involved in the induction and execution phases of apoptosis. This type of programmed cell death is an essential regulatory process required to maintain the integrity and homeostasis of multicellular organisms. Inappropriate apoptosis is attributed a key role in many human diseases, including neurodegenerative ...
Hans-Georg, Häcker, Mihiret Tekeste, Sisay, Michael, Gütschow   +2 more
openaire   +2 more sources

Allosteric modulation of G-protein coupled receptors

European Journal of Pharmaceutical Sciences, 2004
The superfamily of G-protein coupled receptors (GPCRs) has more than 1000 members and is the largest family of proteins in the body. GPCRs mediate signalling of stimuli as diverse as light, ions, small molecules, peptides and proteins and are the targets
Anders A Jensen, Tracy A Spalding
exaly   +2 more sources

Allosteric modulation of nicotinic acetylcholine receptors

Biochemical Pharmacology, 2007
Allosteric modulation refers to the concept that proteins could exist in multiple conformational states and that binding of allosteric ligands alters the energy barriers or "isomerization coefficients" between various states.
Daniel Bertrand, Murali Gopalakrishnan
exaly   +2 more sources

Allosteric Agonist Modulators

Journal of Receptors and Signal Transduction, 2007
This article discusses a model to describe the effects of molecules that bind to a site on the receptor separate from that of the endogenous agonist to actively produce receptor signals (direct agonism). In addition, these molecules also modify the biological responses of the endogenous agonist (either potentiation or antagonism).
openaire   +2 more sources

Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator

Biochemistry, 2023
The NTSR1 neurotensin receptor (NTSR1) is a G protein-coupled receptor (GPCR) found in the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide ligand. In the brain, NTS modulates dopamine neuronal activity, induces opioid-independent analgesia, and regulates food intake.
Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Xi-Ping Huang, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth   +14 more
openaire   +2 more sources