Results 51 to 60 of about 36,012 (161)

Voltage-dependent dynamics of the BK channel cytosolic gating ring are coupled to the membrane-embedded voltage sensor

eLife, 2018
In humans, large conductance voltage- and calcium-dependent potassium (BK) channels are regulated allosterically by transmembrane voltage and intracellular Ca2+.
Pablo Miranda, Miguel Holmgren, Teresa Giraldez   +2 more
doaj   +1 more source

Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulations.

PLoS Computational Biology, 2012
Investigating ligand-regulated allosteric coupling between protein domains is fundamental to understand cell-life regulation. The Hsp70 family of chaperones represents an example of proteins in which ATP binding and hydrolysis at the Nucleotide Binding ...
Federica Chiappori, Ivan Merelli, Giorgio Colombo, Luciano Milanesi, Giulia Morra   +4 more
doaj   +1 more source

Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors.

PLoS Biology, 2013
Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distinct site. There is growing evidence that allosteric cooperativity can be communicated by modulation of protein dynamics without conformational change ...
Thomas L Rodgers, Philip D Townsend, David Burnell, Matthew L Jones, Shane A Richards, Tom C B McLeish, Ehmke Pohl, Mark R Wilson, Martin J Cann   +8 more
doaj   +1 more source

Mechanistic Insights into the Mechanism of Allosteric Inhibition of Ubiquitin-Specific Protease 7 (USP7)

Biomolecules
Ubiquitin-specific protease 7 (USP7), a deubiquitinase enzyme responsible for removing ubiquitin (Ub) from target proteins, plays a crucial role in oncogenic pathways and has been implicated in various human diseases.
Xuebin Wang, Ning Liu, Nuan Li, Shaoyong Lu, Zongtao Chai   +4 more
doaj   +1 more source

Allosteric modulation of dextromethorphan binding sites

Neuropharmacology, 1987
The nonopioid antitussives dextromethorphan (DM), carbetapentane and caramiphen are efficacious anticonvulsant agents in the rat MES test. The findings presented strongly suggest the existence of a novel allosteric mechanism by which drugs acting at two different but interacting sites, exert their effects.
J M, Musacchio, M, Klein, L J, Santiago
openaire   +2 more sources

Allosteric Lever: Toward a Principle of Specific Allosteric Response

Physical Review X
Allostery, the phenomenon by which the perturbation of a molecule at one site alters its behavior at a remote functional site, enables control over biomolecular function.
Maximilian Vossel, Bert L. de Groot, Aljaž Godec   +2 more
doaj   +1 more source

Exploiting protein flexibility to predict the location of allosteric sites

BMC Bioinformatics, 2012
Background Allostery is one of the most powerful and common ways of regulation of protein activity. However, for most allosteric proteins identified to date the mechanistic details of allosteric modulation are not yet well understood.
Panjkovich Alejandro, Daura Xavier
doaj   +1 more source

Positive allosteric modulation of insect olfactory receptor function by ORco agonists

Frontiers in Cellular Neuroscience, 2016
Insect olfactory receptors (ORs) are heteromeric ligand-gated cation channels composed of a common olfactory receptor subunit (ORco) and a variable subunit (ORx) of as yet unknown structures and undetermined stoichiometries.
Panagiota Tsitoura, Kostas Iatrou
doaj   +1 more source

Free fatty acid receptor 2 allosterism is defined by cellular context

Cell Communication and Signaling
Background Allosteric modulators offer a way to fine-tune GPCR signaling in the presence of endogenous ligands. The short-chain fatty acid receptor FFA2R (GPR43) recognizes propionate and allosteric ligands such as Cmp58 and AZ1729.
Simon Lind, Ayaan Abdi Ali, Sarah Al Hamoud Al Asswad, Volker M. Lauschke, Huamei Forsman, Claes Dahlgren, Linda C. Johansson   +6 more
doaj   +1 more source

A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D

Nature Communications
Modulation of protein function through allosteric regulation is central in biology, but biomacromolecular systems involving multiple subunits and ligands may exhibit complex regulatory mechanisms at different levels, which remain poorly understood. Here,
Zhihong Xiao, Jinyin Zha, Xu Yang, Tingting Huang, Shuxin Huang, Qi Liu, Xiaozheng Wang, Jie Zhong, Jianting Zheng, Rubing Liang, Zixin Deng, Jian Zhang, Shuangjun Lin, Shaobo Dai   +13 more
doaj   +1 more source