Results 61 to 70 of about 36,012 (161)

Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase

Journal of Enzyme Inhibition and Medicinal Chemistry
Cell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo.
Elisa Rojas-Prats, Loreto Martinez-Gonzalez, Carmen Gil, David Ramírez, Ana Martinez   +4 more
doaj   +1 more source

Anxiety disorders and GABA neurotransmission: a disturbance of modulation

Neuropsychiatric Disease and Treatment, 2015
Philippe Nuss1,21Department of Psychiatry, Hôpital St Antoine, AP-HP, 2UMR 7203, INSERM ERL 1057 – Bioactive Molecules Laboratory, Pierre and Marie Curie University, Paris, FranceAbstract: Lines of evidence coming from many branches of ...
Nuss P
doaj  

Determination of the Cannabinoid CB1 Receptor’s Positive Allosteric Modulator Binding Site through Mutagenesis Studies

Pharmaceuticals
Positive allosteric modulators (PAMs) of the cannabinoid CB1 receptor (CB1) offer potential therapeutic advantages in the treatment of neuropathic pain and addiction by avoiding the adverse effects associated with orthosteric CB1 activation.
Hayley M. Green, Daniel M. J. Fellner, David B. Finlay, Daniel P. Furkert, Michelle Glass   +4 more
doaj   +1 more source

Allosteric Modulator [PDF]

, 2020
openaire   +1 more source

Molecular determinants of allosteric modulation of protein disulfide isomerase by small-molecule b'-ligands. [PDF]

Redox Biol
Ponzar N, Pagotto A, Bandyopadhayay S, Meyers MJ, De Filippis V, Flaumenhaft R, Pozzi N.   +6 more
europepmc   +1 more source

Discovery and mechanism of negative allosteric modulation of the α7 nicotinic acetylcholine receptor by nanobodies. [PDF]

Proc Natl Acad Sci U S A
Barilone N, Vangelatou M, Marouf FZ, Dejean de la Bâtie G, Li Q, Lafaye P, Aymé G, Corringer PJ, Prevost MS.   +8 more
europepmc   +1 more source

Allosteric Modulators of Drug Targets [PDF]

Journal of Medicinal Chemistry, 2018
openaire   +2 more sources

Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2. [PDF]

Nat Commun
Li M, Bao X, Chen W, Guo Y, Mao X, Xiao M, Liu S, Li J, Zhao L, Chang T, Zhong F, Wang C, Liu H.   +12 more
europepmc   +1 more source

Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation. [PDF]

Proc Natl Acad Sci U S A
Wang J, Nguyen ATN, Adediwura VA, Lu CS, McNeill SM, Jörg M, Scammells PJ, Christopoulos A, May LT, Miao Y.   +9 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies. [PDF]

Adv Sci (Weinh)
Silva A, Duarte-Silva S, Martins PM, Rodrigues B, Serrenho D, Vilasboas-Campos D, Teixeira-Castro A, Vieyto-Nuñez J, Mieres-Perez J, Figueiredo F, Podlasiak M, Van-der-Kellen T, Fraga J, Noble J, Lantz C, Sepanj N, Monteiro-Fernandes D, Guerreiro S, Neves-Carvalho A, Pereira-Sousa J, Klärner FG, Schrader T, Loo JA, Pastore A, Sanchez-Garcia E, Bitan G, Carvalho AL, Maciel P, Macedo-Ribeiro S.   +28 more
europepmc   +1 more source